Results 21 to 30 of about 565,658 (299)

Peran Magnesium Sulfat dalam Menurunkan Kadar TNF-α dan IL-1β pada Bayi Prematur

Jurnal Kedokteran Brawijaya, 2017
Prematuritas menyebabkan mortalitas dan morbiditas neonatus yaitu cerebral palsy (CP), gangguan kognitif dan gangguan tingkah laku. Sitokin proinflamasi TNF-α dan IL-1β diduga secara signifikan meningkat pada bayi prematur. Magnesium sulfat (MgSO4) diduga dapat sebagai neuroprotektor terhadap otak janin, melindungi jaringan terhadap aktivitas radikal
Sri Sulistyowati, Ferri Waluyo Wiwoho Pujojati, Supriyadi Hari Respati, Soetrisno - -   +3 more
openaire   +2 more sources

Penurunan Luaran Neurodevelopmental pada Sepsis Neonatal terjadi melalui Peningkatan IL- 6 dan bukan TNF-α

Jurnal Kedokteran Brawijaya, 2015
Bayi yang mengalami gangguan pada masa prenatal, natal dan paska natal mempunyai risiko tinggi untuk mendapatkan hambatan tumbuh kembang secara optimal dibandingkan bayi lainnya. IL-6 dan TNF-α merupakan salah satu sitokin yang diproduksi saat terjadi sepsis dan mempunyai peranan pada perkembangan otak sebagai sinyal proinflamasi.
Rahmawati Aminingrum, Ariani Ariani, M Istiadjid ES   +2 more
openaire   +2 more sources

The inflammatory cytokine tumor necrosis factor modulates the expression of Salmonella typhimurium effector proteins

Journal of Inflammation, 2010
Tumor necrosis factor α (TNF-α)is a host inflammatory factor. Bacteria increase TNF-α expression in a variety of human diseases including infectious diseases, inflammatory bowel diseases, and cancer.
Ma Jun, Zhang Yong-guo, Xia Yinglin, Sun Jun   +3 more
doaj   +1 more source

Regulatory T cells in Crohn's disease following anti‐TNF‐α therapy

JGH Open, 2020
Background and Aim Anti‐tumor necrosis factor alpha (TNF‐α) therapy is an effective therapy for Crohn's disease (CD). We investigated FoxP3+ and CD127− regulatory T cells (Tregs) before and after administration of anti‐TNF‐α therapy in CD.
Toshimi Chiba, Mikiya Endo, Shoko Miura, Yuko Hayashi, Yoshiko Asakura, Kotaro Oyama, Takayuki Matsumoto   +6 more
doaj   +1 more source

Korelasi Kadar Vitamin D, dengan TNF-α dan Manifestasi Klinis pada Pasien Artritis Rematoid

Jurnal Kedokteran Brawijaya, 2014
Artritis rematoid (AR) adalah penyakit autoimun yang ditandai dengan sinovitis erosif simetrik, diawali dengan  aktivasi sel T dependent antigen yang akan mencetuskan respon imun, terutama tipe Th1. Tumor necrosis factor (TNF-α) adalah sitokin sentral pada patogenesis AR.  Diketahui bahwa defisiensi vitamin D berkaitan dengan eksaserbasi respon imun
Hanik Ruliani, Handono Kalim, BP Putra Suryana, Kusworini Handono   +3 more
openaire   +2 more sources

TNF-α and Interleukin-6 Levels in Clinical Early Onset Neonatal Sepsis Toward Acute Liver Injury

Jurnal Kedokteran Brawijaya, 2016
TNF-α and IL-6 level have an important role in acute liver injury during early onset neonatal sepsis. This study aims to investigate the correlation of TNF-α and IL-6 levels in neonates with clinical early onset neonatal sepsis toward the occurrence of acute liver injury 44 neonates with clinical early onset neonatal sepsis based on SIRS criteria and
Diani Dinarshanty, Noorhamdani AS, Siti Lintang Kawuryan, Satrio Wibowo   +3 more
openaire   +1 more source

Peptide-Based Regulation of TNF-α-Mediated Cytotoxicity

Biomolecules
Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine associated with TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), which play important roles in several inflammatory diseases.
Betul Zehra Temur, Ahmet Can Timucin, Ahmet Emin Atik, Tanil Kocagoz, Ozge Can   +4 more
doaj   +1 more source

Establishment of a consistent L929 bioassay system for TNF-α quantitation to evaluate the effect of lipopolysaccharide, phytomitogens and cytodifferentiation agents on cytotoxicity of TNF-α secreted by adherent human mononuclear cells

Mediators of Inflammation, 2001
Tumor necrosis factor-α (TNF-α ) plays an important role in the pathogenesis of rheumatoid arthritis. The present study was to evaluate the effects of lipopolysaccharide (LPS), phytomitogens and cytodifferentiation agents on cytotoxicity of TNF-α ...
Ming-Yuh Shiau, Hui-Ling Chiou, Yao-Ling Lee, Tzer-Min Kuo, Yih-Hsin Chang   +4 more
doaj   +1 more source

TNF-α gene polymorphisms: association with age-related macular degeneration in Russian population [PDF]

International Journal of Ophthalmology, 2019
AIM: To study polymorphisms in promotor regions of tumor necrosis factor (TNF)-α TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), and TNF-238A/G (rs361525) in patients with age-related macular degeneration (AMD) and associations of complex TNF-α genotypes
Valeriy Chernykh, Alla Shevchenko, Vladimir Konenkov, Viktor Prokofiev, Alena Eremina, Alexander Trunov   +5 more
doaj   +1 more source

Mechanism of inhibitory effect of atorvastatin on resistin expression induced by tumor necrosis factor-α in macrophages

Journal of Biomedical Science, 2009
Atorvastatin has been shown to reduce resistin expression in macrophages after pro-inflammatory stimulation. However, the mechanism of reducing resistin expression by atorvastatin is not known. Therefore, we sought to investigate the molecular mechanisms
Chua Su-Kiat, Shyu Kou-Gi, Wang Bao-Wai, Kuan Peiliang   +3 more
doaj   +1 more source