Results 51 to 60 of about 565,658 (299)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Exhaled Volatile Organic Compounds during Inflammation Induced by TNF-α in Ventilated Rats

Metabolites, 2020
Systemic inflammation alters the composition of exhaled breath, possibly helping clinicians diagnose conditions such as sepsis. We therefore evaluated changes in exhaled breath of rats given tumor necrosis factor-alpha (TNF-α). Thirty male Sprague-Dawley
Frederic W. Albrecht, Felix Maurer, Lukas M. Müller-Wirtz, Michaela H. Schwaiblmair, Tobias Hüppe, Beate Wolf, Daniel I. Sessler, Thomas Volk, Sascha Kreuer, Tobias Fink   +9 more
doaj   +1 more source

The Antiviral Effects of Jasminin via Endogenous TNF-α and the Underlying TNF-α-Inducing Action

Molecules, 2022
Previous studies have reported that recombinant tumor necrosis factor (TNF)-α has powerful antiviral activity but severe systematic side effects. Jasminin is a common bioactive component found in Chinese herbal medicine beverage “Jasmine Tea”.
Xiaohong Zhu, Ziwei Hu, Tian Yu, Hao Hu, Yunshi Zhao, Chenyang Li, Qinchang Zhu, Mingzhong Wang, Peng Zhai, Longxia He, Muhammad Shahid Riaz Rajoka, Xun Song, Zhendan He   +12 more
doaj   +1 more source

TNF-α-mediated activation of HIV-1 LTR in monocytoid cells by mycobacteria [PDF]

FEMS Immunology & Medical Microbiology, 2001
Mycobacterial infection occurs commonly in patients with acquired immune deficiency syndrome. Incubation of monocytoid cell line U937 cells, which was cotransfected HIV-1 long terminal repeat sequence (LTR) chloramphenicol acetyltransferase (CAT) plasmid and Tat expression plasmid, with Mycobacterium smegmatis, Mycobacterium avium, Mycobacterium bovis ...
H, Kitaura, N, Ohara, K, Kobayashi, T, Yamada   +3 more
openaire   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Familial Aggregation of High Tumor Necrosis Factor Alpha Levels in Systemic Lupus Erythematosus

Clinical and Developmental Immunology, 2013
Systemic lupus erythematosus (SLE) patients frequently have high circulating tumor necrosis factor alpha (TNF-α) levels. We explored circulating TNF-α levels in SLE families to determine whether high levels of TNF-α were clustered in a heritable pattern.
Dorothy Mangale, Silvia N. Kariuki, Beverly S. Chrabot, Marissa Kumabe, Jennifer A. Kelly, John B. Harley, Judith A. James, Kathy L. Sivils, Timothy B. Niewold   +8 more
doaj   +1 more source

Efek Ekstrak Propolis terhadap Ekspresi TNF-α, Apoptosis dan Nekrosis Jaringan Otak Tikus Model Traumatic Brain Injury (TBI)

Jurnal Kedokteran Brawijaya, 2016
Ekstrak propolis merupakan produk lebah dengan berbagai kandungan aktif yang memiliki efek antioksidan, antiinflamasi, proteksi DNA, neuroprotektan dan immunomodulator. Propolis mampu menurunkan reaksi inflamasi melalui hambatan terhadap aktivitas TNF-α dan NF-κB, mampu menurunkan Bax dan caspase-3, dan meningkatkan Bcl-2, yang berperan pada jalur ...
Ashalia Chandra Dewi, Mulyohadi Ali, Hari Purnomo   +2 more
openaire   +2 more sources

Development of hematogenous pneumococcal meningitis in adult mice: the role of TNF-α [PDF]

FEMS Immunology & Medical Microbiology, 2002
Bacterial penetration across the blood-brain barrier (BBB) into the central nervous system is the first step in development of meningitis. The role of tumor necrosis factor-alpha (TNF-alpha) in the penetration process was examined with peripheral infection of Streptococcus pneumoniae type 6. After intraperitoneal infection of S.
N, Tsao, W W, Chang, C C, Liu, H Y, Lei
openaire   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source