Results 61 to 70 of about 565,658 (299)

TNF-α enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways

Journal for ImmunoTherapy of Cancer, 2019
Tumor specific Th9 cells are potential effector cells for adoptive therapy of human cancers. TNF family members OX40L, TL1A and GITRL have been shown to promote the induction of Th9 cells and antitumor immunity.
Yuxue Jiang, Jintong Chen, Enguang Bi, Yinghua Zhao, Tianxue Qin, Yiming Wang, Alison Wang, Sujun Gao, Qing Yi, Siqing Wang   +9 more
doaj   +1 more source

Luteolin prevents TNF-α-induced NF-κB activation and ROS production in cultured human placental explants and endothelial cells [PDF]

, 2023
Adrian C. Eddy, Augustine Rajakumar, Frank T. Spradley, Joey P. Granger, Sarosh Rana   +4 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Insulin attenuates TNFα-induced hemopexin mRNA: An anti-inflammatory action of insulin in rat H4IIE hepatoma cells

Biochemistry and Biophysics Reports, 2017
Proinflammatory cytokines, including TNF-α and IL-6, can contribute to insulin resistance. Conversely, insulin has some actions that can be considered anti-inflammatory.
J. Lee Franklin, William L. Bennett, Joseph L. Messina   +2 more
doaj   +1 more source

THE INFLUENCE OF PEPAYA LEAF STEW (CARICA PAPAYA) ON PROSTAGLANDIN (PGF2 α) AND TNF-α LEVELS IN DISMENOREA PATIENTS

Jurnal Kesehatan, 2023
Analysis:The prevalence of dysmenorrhoea in Indonesia is quite high at 64.25%. Several factors are known as a factor in the occurrence of dysmenorrhoea among others is the increased synthesis of Prostaglandins (PGF2α) and Cytokines (TNFαα) as mediators that play an important role besides PGF2α in the inflammatory process.Method:The purpose of this ...
Nisa, Setia, Maifita, Yesi
openaire   +1 more source

KORELASI KADAR CRP, TNF-α DAN BONE MINERAL DENSITY DENGAN CARBOXYTERMINAL CROSSLINKED TELOPEPTIDE TYPE I OF COLLAGEN DI PENDERITA ARTRITIS REUMATOID

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2018
Rheumatoid Arthritis (RA) is a systemic autoimmune disease accompanied by decreasing bone mass density and ultimately leads toosteoporosis. The cause of decreased bone mass density is still unknown, but the inflammation has been suspected as an important factor.The correlation between the severity of inflammation with the decrease in bone mass density ...
Kusworini Handono, BP Putra Suryana, Sulistyorini Sulistyorini   +2 more
openaire   +2 more sources

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Ekstrak Metanol Daun Kelor Menurunkan Kadar TNF-α dan IL-6 Serum, serta MDA Kolon Tikus yang Diinduksi DMBA

Jurnal Kedokteran Brawijaya, 2016
Ekstrak daun kelor (Moringa oleifera) dapat berfungsi sebagai anti oksidan, anti radang, dan anti kanker.TNF-α dan IL-6 merupakan sitokin proinflamasi yang berperan penting pada patogenesis kanker, sedangkan pada jaringan kanker sering ditemukan peningkatan kadar MDA.
Tinny Endang H, Dian Sukma H
openaire   +1 more source

The ability of earthworm Lumbricus rubellus extract in slowing down the activation of NFkB and TNF-α in lipopolysaccharide-induced Rattus norvegicus

Bali Medical Journal, 2019
Background: Earthworm (L. rubellus) contains many compounds such as Lumbricin I, G-90 glycoprotein, and polyphenols as antimicrobial, antioxidant, and hepatoprotective toward bacterial infections. Tumor necrosis factor (TNF-α) has been identified as a mediator for necrosis tumor inside animal serum treated by lipopolysaccharide (LPS).
Neiny Prisy Foekh, I Dewa Made Sukrama, Anak Agung Wiradewi Lestari   +2 more
openaire   +1 more source