Tnf-related apoptosis-inducing ligand

Results 31 to 40 of about 10,050,273 (238)

Downregulation of endogenous TRAIL and its effect on the human cancer cell line KELLY [PDF]

, 2011
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to exert an unexpected pro-survival, pro-proliferative and pro-invasive effect on a subset of human cancer cell lines. Recent clinical studies report that increased expression
Brittingham, Sara, Brittingham, S.
core +1 more source

TNF Superfamily: A Growing Saga of Kidney Injury Modulators

Mediators of Inflammation, 2010
Members of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury.
Maria D. Sanchez-Niño +11 more
doaj +1 more source

Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation [PDF]

International Journal of Molecular Sciences, 2018
Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L (Apo-2 ligand), is a cytokine of the TNF superfamily acknowledged for its ability to trigger selective apoptosis in tumor cells while being relatively safe towards normal cells.
openaire +4 more sources

The Journal of Immunology, 2001
Abstract TRAIL, the TNF-related apoptosis-inducing ligand, induces apoptosis of tumor cells, but not normal cells; the roles of TRAIL in nontransformed tissues are unknown. Using a soluble TRAIL receptor, we examined the consequences of TRAIL blockade in an animal model of multiple sclerosis.
B, Hilliard +5 more
openaire +2 more sources

Expression of TRAIL and Fas in Primary Hyperparathyroidism

Journal of Investigative Surgery, 2017
Aim: Differentiating between parathyroid lesions is still difficult and ambiguous. In cases of primary hyperparathyroidism, appropriate and prompt diagnosis is of great importance for effective treatment and follow-up.
Oliwia Anna Segiet +6 more
doaj +1 more source

PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines. [PDF]

PLoS ONE, 2015
While PCTAIRE1/PCTK1/Cdk16 is overexpressed in malignant cells and is crucial in tumorigenesis, its function in apoptosis remains unclear. Here we investigated the role of PCTAIRE1 in apoptosis, especially in the extrinsic cell death pathway.
Teruki Yanagi +4 more
doaj +1 more source

Identification of the biochemical signalling mechanisms underlying CD40 killing in colorectal cancer cells [PDF]

CD40 is a member of the tumour necrosis factor receptor (TNFR) superfamily and ligation by membrane- presented CD40 ligand (mCD40L), but not soluble agonists, causes extensive apoptosis in malignant epithelial cells, including colorectal carcinoma ...
Mohamed, Albashir
core +3 more sources

BioMed Research International, 2015
TNF-related apoptosis inducing ligand (TRAIL) is an intensively studied cytokine, in particular for its anticancer activity. The discovery that conjunctival sac fluid contains extremely high levels of soluble TRAIL as compared to other body fluids suggested important implications in the context of the immunological surveillance of the eye, in ...
PERRI, Paolo +6 more
openaire +5 more sources

Scientific Reports, 2017
High serum concentrations of TNF-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor protein family, are found in patients with increased BMI and serum lipid levels.
Verena Zoller +10 more
doaj +1 more source

The Janus face of death receptor signalling during tumour immunoediting.

Frontiers in Immunology, 2016
Cancer immune-surveillance is essential for the inhibition of carcinogenesis. Malignantly transformed cells can be recognised by both the innate and adaptive immune systems through different mechanisms.
Eimear O' Reilly +3 more
doaj +1 more source

apoptosis
trail
medicine

cancer
pathology