Results 11 to 20 of about 10,050,273 (238)

TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling

Cells
TNF-related apoptosis-inducing ligand (TRAIL or Apo2 or TNFSF10) belongs to the TNF superfamily. When bound to its agonistic receptors, TRAIL can induce apoptosis in tumour cells, while sparing healthy cells.
Abderrahmane Guerrache, Olivier Micheau
doaj   +4 more sources

TNF-related apoptosis-inducing ligand deficiency enhances survival in murine colon ascendens stent peritonitis

Journal of Inflammation Research, 2016
Katharina Beyer,1 Laura Stollhof,1 Christian Poetschke,2 Wolfram von Bernstorff,1 Lars Ivo Partecke,1 Stephan Diedrich,1 Stefan Maier,1 Barbara M Bröker,2 Claus-Dieter Heidecke1 1Department of General, Visceral, Thoracic, and Vascular Surgery ...
Beyer K, Stollhof L, Poetschke C, von Bernstorff W, Partecke LI, Diedrich S, Maier S, Bröker BM, Heidecke CD   +8 more
doaj   +1 more source

TNF-related apoptosis-inducing ligand: Signalling of a 'smart’ molecule

The International Journal of Biochemistry & Cell Biology, 2009
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor super-family and signals via two death receptors, TRAIL-R1 and TRAIL-R2, and two decoy receptors, TRAIL-R3 and TRAIL-R4, differently expressed in normal and cancer cells.
MANZO F, NEBBIOSO, Angela, MICELI M, CONTE M, DE BELLIS F, CARAFA V, FRANCI G, TAMBARO FP, ALTUCCI, Lucia   +8 more
openaire   +6 more sources

Immunomodulatory Functions of TNF-Related Apoptosis-Inducing Ligand in Type 1 Diabetes

Cells
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF protein superfamily and was initially identified as a protein capable of inducing apoptosis in cancer cells.
Marton Fogarasi, Simona Dima
doaj   +3 more sources

Cutting edge:Lymphocyte inhibitor of TRAIL (TNF-related apoptosis- inducing ligand): A new receptor protecting lymphocytes from the death ligand TRAIL

, 1998
Apoptosis can be triggered by the engagement of cell surface receptors by their ligands. A growing number of receptors belonging to the TNF receptors family have been identified that contain a conserved cytoplasmic death domain. These include Fas, TNF-R1,
McMichael, Andrew J., Cowper, Alison E., Xu, Xiao Ning, Bell, John I., Morris, Gwilym; id_orcid, Screaton, Gavin R., Mongkolsapaya, Juthathip   +6 more
core   +11 more sources

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Cartwright, JE, Aplin, JD, Whitley, GS, Keogh, RJ, Freeman, A, Harris, LK, Baker, PN   +6 more
core   +1 more source

Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21(waf1/cip1) [PDF]

, 2001
Background/Aims: We investigated the effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone on growth and TRAIL-induced apoptosis in carcinoid cells.
Göke, Burkhard, Göke, Rüdiger, Chen, Youhai, El-Deiry, Wafik S., Göke, Alexandra   +4 more
core   +1 more source

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines [PDF]

, 2009
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5).
M Keane, Mehmet, H, A Samali, D Mahalingam, H Mehmet, Mahalingam, D, E Szegezdi, Szegezdi, E, Keane, M, G Pirianov, Pirianov, G, Samali, A   +11 more
core   +1 more source

Activity of TNF‐related apoptosis‐inducing ligand (TRAIL) in haematological malignancies [PDF]

British Journal of Haematology, 1997
T‐cell cytotoxicity is primarily mediated by two cell surface proteins, Fas ligand (FasL) and tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), and intracellular perforin and granzyme granules. FasL‐deficient and perforin‐deficient T lymphocytes maintain cytotoxicity but fail to induce graft‐versus‐host disease (GVHD) when transplanted ...
V, Snell, K, Clodi, S, Zhao, R, Goodwin, E K, Thomas, S W, Morris, M E, Kadin, F, Cabanillas, M, Andreeff, A, Younes   +9 more
openaire   +2 more sources

CHRYSIN MENINGKATKAN EFEK SITOTOKSIK TNF-RELATED APOPTOSIS-INDUCING LIGAND TERHADAP SEL HEK293 [PDF]

, 2017
-TNF-related apoptosis-inducing ligand merupakan salah satu pilihan pengobatan kanker yang secara efektif dapat menginduksi apoptosis melalui aktivasi death receptor (DR4 dan DR5). Penggunaan TNF-related apoptosis-inducing ligand menyebabkan efek samping
habibie, habibie
core   +1 more source