Nanocrystallization of Rare Tolbutamide Form V in Mesoporous MCM-41 Silica [PDF]
Molecular Pharmaceutics, 2018 Encapsulation of pharmaceuticals inside nanoporous materials is of increasing interest due to their possible applications as new generation therapeutics, theranostic platforms, or smart devices.
Karol P Nartowski +2 more
exaly +6 more sources
Selection of an Optimal Metabolic Model for Accurately Predicting the Hepatic Clearance of Albumin-Binding-Sensitive Drugs [PDF]
PharmaceuticalsBackground/Objectives: Hepatic clearance is important in determining clinical drug administration strategies. Achieving accurate hepatic clearance predictions through in vitro-to-in vivo extrapolation (IVIVE) relies on appropriate model selection, which ...
Ren-Jong Liang +7 more
doaj +2 more sources
Live Cell Monitoring of Phosphodiesterase Inhibition by Sulfonylurea Drugs [PDF]
BiomoleculesSulfonylureas (SUs) are a class of antidiabetic drugs widely used in the management of diabetes mellitus type 2. They promote insulin secretion by inhibiting the ATP-sensitive potassium channel in pancreatic β-cells.
Filip Berisha +2 more
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In Vitro Investigation of the Interaction of Tolbutamide and Losartan with Human Serum Albumin in Hyperglycemia States [PDF]
Molecules, 2017 Serum albumin is exposed to numerous structural modifications which affect its stability and activity. Glycation is one of the processes leading to the loss of the original properties of the albumin and physiological function disorder.
Agnieszka Szkudlarek +4 more
doaj +2 more sources
Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca2+ in Female Mouse Islets Stimulated by Glucose and Tolbutamide [PDF]
Endocrinology, 2014 Jean-Claude Henquin
exaly +2 more sources
Microbiome and metabolome explain the high-fat diet-induced diabetes development and diabetes resistance in Guizhou mini-pigs [PDF]
Frontiers in MicrobiologyType 2 diabetes mellitus (T2DM) is an obesity-related disease claiming substantial global mortality annually. Current animal models of T2DM remain limited, with low success rates in establishing porcine models of high-fat diet (HFD)-induced T2DM.
Yanjun Wu +11 more
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Frontiers in Pharmacology, 2021 Warfarin is a widely prescribed anticoagulant but the doses required to attain the optimum therapeutic effect exhibit dramatic inter-individual variability. Pharmacogenomics-guided warfarin dosing has been recommended to improve safety and effectiveness.
Xiao-Yang Zhou +14 more
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Solubility Enhancement of Antidiabetic Drugs Using a Co‐Crystallization Approach
ChemistryOpen, 2021 The co‐crystallization approach has been used to enhance specific desirable properties of active pharmaceutical ingredients (APIs) such as solubility, dissolution rate, and stability.
Dr. Eustina Batisai
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Journal of Advanced Research, 2022 Introduction: Pharmacokinetic variability in disease state is common in clinical practice, but its underlying mechanism remains unclear. Recently, gut microbiota has been considered to be pharmacokinetically equivalent to the host liver.
Jing Guo +9 more
doaj +1 more source