Within-Sulfonylurea-Class Evaluation of Time to Intensification with Insulin (ZODIAC-43). [PDF]
PLoS ONE, 2016 Previous studies have shown that many within-class differences exist between sulfonylureas (SUs), however, whether differences exist regarding the time it takes between initiating an SU and the need to intensify treatment with insulin is unclear. The aim
Dennis Schrijnders +5 more
doaj +1 more source
Crystal structure of 4-bromo-N-(propylcarbamoyl)benzenesulfonamide
Acta Crystallographica Section E: Crystallographic Communications, 2022 The title compound, C10H13BrN2O3S, 1, contains a sulfonyl urea moiety, which possesses potential therapeutic functions (e.g., anti-diabetic and herbicidal).
Mustafa Bookwala +3 more
doaj +1 more source
Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro [PDF]
, 1989 The action of the potassium channel activator, cromakalim (BRL 34915), on membrane potential, input resistance and current-voltage-relationship of CA3 neurons in a slice preparation of the guinea-pig hippocampus was investigated by means of intracellular
Alzheimer, Christian +2 more
core +1 more source
Xiao chai hu tang for liver diseases: A literature review
World Journal of Traditional Chinese Medicine, 2017 The objective of this study is to summarize the pharmacological effects and the mechanisms of action of Xiao Chai Hu Tang (XCHT, Minor Bupleurum Decoction) on liver diseases, so as to give relevant researchers a valuable insight and benefit patients with
Yi Wang +3 more
doaj +1 more source
Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination. [PDF]
PLoS ONE, 2013 Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated.
Eva Tudurí +5 more
doaj +1 more source
Bone Marrow Mesenchymal Stromal Cells and Their Derived Extracellular Vesicles Protect Pancreatic Beta-TC-6 Cells From Hypoxia-Induced Injury via miR-539-3p-Mediated Downregulation of CD36 Expression. [PDF]
Stem Cells IntBone marrow mesenchymal stromal cells (BMSCs) have been shown to enhance the function of pancreatic beta‐cells under hypoxic conditions. However, the precise mechanisms underlying this protective effect remain elusive. In this study, we established a hypoxic beta‐cell model using murine pancreatic beta‐TC‐6 cells to investigate the protective effect ...
Lin N +9 more
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Automation potential of a new, rapid, microscopy based method for screening drug-polymer solubility [PDF]
, 2020 For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polymeric excipients can often be time-consuming because of the use of trial-and-error approaches.
Alhijjaj, Muqdad +4 more
core +1 more source
Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]
, 2012 Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J. +5 more
core +2 more sources
Effect of Temperature on Tolbutamide Binding to Glycated Serum Albumin
Molecules, 2017 Glycation process occurs in protein and becomes more pronounced in diabetes when an increased amount of reducing sugar is present in bloodstream. Glycation of protein may cause conformational changes resulting in the alterations of its binding properties
Agnieszka Szkudlarek +4 more
doaj +1 more source
Simvastatin Rapidly and Reversibly Inhibits Insulin Secretion in Intact Single-Islet Cultures [PDF]
, 2016 open10Epidemiological studies suggest that statins may promote the development or exacerbation of diabetes, but whether this occurs through inhibition of insulin secretion is unclear.
Alessandro Zambon +9 more
core +2 more sources