Results 51 to 60 of about 22,677 (265)
British Journal of Pharmacology, EarlyView.Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng +5 more
wiley +1 more source
KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons
Frontiers in Cellular Neuroscience, 2014 Medial temporal lobe structures are essential for memory formation which is associated with coherent network oscillations. During ontogenesis, these highly organized patterns develop from distinct, less synchronized forms of network activity.
Maria S. Lemak +6 more
doaj +1 more source
BK channels reveal novel phosphate sensitivity in SNr neurons. [PDF]
PLoS ONE, 2012 Whether large conductance Ca(2+)-activated potassium (BK) channels are present in the substantia nigra pars reticulata (SNr) is a matter of debate. Using the patch-clamp technique, we examined the functional expression of BK channels in neurons of the ...
Juan Juan Ji +9 more
doaj +1 more source
Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis [PDF]
, 1990 An abnormal ratio between Na+ and K+ conductances seems to be the cause for the depolarization and paralysis of skeletal muscle in primary hypokalemic periodic paralysis.
Ballanyi +19 more
core +1 more source
Experimental Physiology, EarlyView.Abstract The principal processes that govern interstitial K+ ([K+]o) buffering in mouse optic nerve (MON), a central white matter tract, either directly consume energy (Na+–K+‐ATPase) or use transmembrane ion gradients created by energy‐dependent pumps to enable the K+ fluxes that maintain a stable [K+]o, and thus ready availability of utilisable ...
Amy J. Hopper, Angus M. Brown
wiley +1 more source
Scientific Reports, 2021 Teucrium yemense, a medicinal plant commonly grown in Saudi Arabia and Yemen, is traditionally used to treat infections, kidney diseases, rheumatism, and diabetes.
Mohammad Nur-e-Alam +8 more
doaj +1 more source
Cisapride induced hypoglycemia via the KCNH6 potassium channel
Frontiers in Endocrinology, 2022 Mutations in KCNH6 has been proved to cause hypoinsulinemia and diabetes in human and mice. Cisapride is a stomach–intestinal motility drug used to treat gastrointestinal dysfunction.
Jing Lu +7 more
doaj +1 more source
Lipoatrophic diabetes. Report of a case [PDF]
, 1978 The female patient initially showed the acquired type of total lipoatrophy at about 8 years of age. At 12 years of age, the onset of diabetes mellitus was speculated from advanced pyodermia and dedentition.
Aoi, Katsuyuki +5 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Inwardly rectifying (Kir2) and ATP‐sensitive (KATP) potassium channels are functionally expressed in human pulmonary artery endothelial and smooth muscle cells. The schematic illustrates how Kir2‐ and KATP‐mediated K+ efflux contributes to VM regulation and pulmonary vascular tone.
Bianca Barreira +7 more
wiley +1 more source
Dose Dependent Effect of Sulfamethoxazole on Inhibiting K Channel of Mouse Pancreatic β Cell
Dose-Response, 2023 Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (K ATP ) channels and induces insulin ...
Hiroshi Ogata +7 more
doaj +1 more source