Results 71 to 80 of about 22,677 (265)
Oleate induces KATP channel-dependent hyperpolarisation in mouse hypothalamic glucose-excited neurones without altering cellular energy charge [PDF]
, 2017 This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.The unsaturated fatty acid, oleate exhibits anorexigenic properties reducing food intake and hepatic glucose output.
Abdul-Ghani +77 more
core +3 more sources
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]
, 2015 Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu +3 more
core +1 more source
Journal of Pharmaceutical Analysis, 2016 A sensitive and selective method using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC–ESI–MS) to determine the concentration of torasemide in human plasma samples was developed and validated ...
Lin Zhang +3 more
doaj +1 more source
Neural control of the heart: developmental changes in ionic conductances in mammalian intrinsic cardiac neurons [PDF]
, 2002 The expression and properties of ionic channels were investigated in dissociated neurons from neonatal and adult rat intracardiac ganglia. Changes in the hyperpolarization-activated and ATP-sensitive K+ conductances during postnatal development and their
A.A Harper +17 more
core +1 more source
Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity
Advanced Science, Volume 12, Issue 48, December 29, 2025.KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao +25 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 12, December 2025.ABSTRACT Traumatic brain injury (TBI) causes a high level of blood glutamate, which triggers host defense by activating oxidative stress and inflammation response. However, the concrete mechanism underlying its exacerbating effects on acute lung injury (ALI) severity remains unknown.
Song Zhou +2 more
wiley +1 more source
K-ATP channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]
, 2002 Background-Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.Methods and Results-We have ...
Chanalaris, A +11 more
core
Structure determination of tolbutamide [PDF]
, 1981 N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide, is an antidiabetic drug which crystd. in orthorhombic space group Pn21a, with a 20.16(2), b 9.05(1), c 7.85(1) Å; Z = 4, d.(exptl.) = 1.24 and d.(calcd.) = 1.25 for Z = 4.
Nirmala, K.A., Sake Gowda, D.S.
core +1 more source
Frontiers in Pharmacology, 2014 According to traditional Chinese medicine theories, Euphorbiae Pekinensis Radix and Glycyrrhizae Radix shouldn’t be used together in one prescription, because their interaction leads to an unexpected consequence.
Xinmin eWang +5 more
doaj +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 2095-2106, December 2025.ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins +6 more
wiley +1 more source