Results 51 to 60 of about 16,611,336 (253)

Toll-like receptor 5 on monocyte as a biomarker of mortality risk in patients with sepsis

BMC Infectious Diseases
Objective To evaluate the expression of Toll-like receptor 5 on monocyte at ICU admission as a potentially novel early screening biomarker to predict the mortality risk of sepsis.
Hong Tan, Hanyi Wang, Xuanyi Zhou, Wenjun Que, Xiaoliang Yang   +4 more
doaj   +1 more source

Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction. [PDF]

, 2011
Innate immune activation via IL-1R or Toll-like receptors (TLR) contibutes to acute kidney injury but its role in tissue remodeling during chronic kidney disease is unclear.
Skuginna Veronika, Mantovani Alberto, S. Clauss, Heni Eka Susanti, R. Allam, Skuginna, Veronika, Clauss, Sebastian, Susanti, Heni Eka, Ramanjaneyulu Allam, H. E. Susanti, Hans-Joachim Anders, Christoph Römmele, Sebastian Clauss, M. Lech, Veronika Skuginna, Clauss Sebastian, Cecilia Garlanda, Lech, Maciej, Ryu, Mi, Lech Maciej, Garlanda Cecilia, C. Garlanda, Ryu Mi, Römmele, Christoph, Heni Eka, Mantovani, Alberto, Alberto Mantovani, Anders Hans-Joachim, Allam Ramanjaneyulu, Maciej Lech, Cecilia Garl, M. Ryu, Susanti Heni Eka, A. Mantovani, Anders, Hans-Joachim, Mi Ryu, Allam, Ramanjaneyulu, Römmele Christoph, C. Römmele, H. J. Anders, Garlanda, Cecilia, V. Skuginna   +41 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Immunoprotective Effects of Two Histone H2A Variants in the Grass Carp Against Flavobacterium columnare Infection

Frontiers in Immunology, 2022
In teleost fish, the nucleotide polymorphisms of histone H2A significantly affect the resistance or susceptibility of zebrafish to Edwardsiella piscicida infection.
Yuan Yuan Yang, Yuan Yuan Yang, Si Yao Zheng, Si Yao Zheng, Hong Fang, Hong Fang, Xiao Man Wu, Jie Zhang, Ming Xian Chang, Ming Xian Chang, Ming Xian Chang   +10 more
doaj   +1 more source

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. [PDF]

, 2015
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is ...
Martina Svensson, Osman, AM, Salomonsson, E, Oliva Martín, María José, Annette Persson, Burguillos García, Miguel Ángel, Garcia-Quintanilla, Albert, Nikenza Viceconte, Englund, Elisabet,, Schulte, Tim, Elisabet Englund, Schulte, Tim,, Albert Garcia-Quintanilla, Kavanagh, Edel, Ahmed Mohamed Osman, Santiago, M, Joseph, Bertrand, García-Quintanilla, Alberto, Amar, Lahouari, Deierborg, Tomas,, Persson, A, Venero, Jose Luis, Blomgren, Klas, Englund, E, Leffler, H, Jose Luis Venero, Boza Serrano, Antonio, Burguillos, MA, García Quintanilla, Alberto, Martiniano Santiago, Antonio Boza-Serrano, Hakon Leffler, Joseph, B, Deierborg, Tomas, Englund, Elisabet, Persson, Annette,, Amar, L, Edel Kavanagh, Kavanagh, E, Lund University., Leffler, Hakon,, Emma Salomonsson, Venero, JL, Boza Serrano, Antonio,, Santiago, Martiniano, Venero Recio, José Luis, Amar, Lahouari,, Kavanagh, Edel T., Oliva-Martín, María J., Blomgren, K, Svensson, Martina,, Miguel Angel Burguillos, Viceconte, Nikenza, Bertrand Joseph, Salomonsson, Emma,, Oliva-Martin, Maria Jose, Svensson, Martina, Tim Schulte, Maria Jose Oliva-Martin, Osman, Ahmed Mohamed, Oliva-Martin, MJ, Boza-Serrano, A, Salomonsson, Emma, Persson, Annette, Achour, A, Garcia-Quintanilla, A, Adnane Achour, Achour, Adnane, Burguillos Garcia, Miguel, Viceconte, N, Burguillos Garcia, Miguel,, Santiago Pavón, Martiniano, Schulte, T, Tomas Deierborg, Svensson, M, Venero, José L., Klas Blomgren, Lahouari Amar, Deierborg, T, Burguillos, Miguel Angel, Leffler, Hakon, Boza-Serrano, Antonio   +81 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

How Flagellin and Toll-Like Receptor 5 Contribute to Enteric Infection [PDF]

Infection and Immunity, 2007
Resistance to infection in vertebrates relies on a complex interaction between two separate but complementary arms of the immune system: adaptive immunity and innate immunity. Adaptive immunity refers to the recognition of specific molecular epitopes by either T or B lymphocytes and the ...
openaire   +2 more sources

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
McGivern, David R., Fengyu Hu, Daisuke Yamane (206804), David R McGivern, Hu, Fengyu, Hiromichi Dansako (357935), Nobuyuki Kato (235685), Christoph Welsch (22852), Stanley M. Lemon (30543), Daisuke Yamane, Christoph Welsch, Welsch, Christoph, David R. McGivern (415119), Lemon, Stanley M., Kato, Nobuyuki, Fengyu Hu (415120), Dansako, Hiromichi, Stanley M Lemon, Yamane, Daisuke, Nobuyuki Kato, Hiromichi Dansako   +20 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Activation of Toll-Like Receptor 5 Immune Signaling by HMGB1 [PDF]

Biophysical Journal, 2016
Human High Mobility Group Box-1 (HMGB-1) is an ubiquitously expressed nuclear protein which primarily functions as an architectural chromatin binding factor that binds to DNA in a structure specific manner. Recently, it has been linked to the pathogenesis of several inflammatory diseases regulating the innate immune system by two specific toll-like ...
Das, Nabanita, Dewan, Varun, Hubert Yin, Hang   +2 more
openaire   +1 more source