Results 31 to 40 of about 16,611,336 (253)
Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease
EBioMedicine, 2022 Summary: Background: Crohn's disease (CD) is a chronic inflammatory disorder characterized by intestinal immune dysfunction. Multiple factors, including gut dysbiosis, are involved in the pathogenesis of CD.
Zhaohua Shen +14 more
doaj +1 more source
Chicken Toll-like Receptor 3 Recognizes Its Cognate Ligand When Ectopically Expressed in Human Cells [PDF]
, 2007 Recognition of pathogens by toll-like receptors (TLRs) causes activation of signaling cascades that trigger cytokine secretion and, ultimately, innate immunity.
Kothlow, Sonja +8 more
core +1 more source
, 2005 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders, Hans-Joachim, H-J Anders
core +1 more source
Communications Biology, 2021 Mett et al. describe development of GP532, a substantially deimmunized derivative of Toll-like receptor 5 (TLR5) agonist entolimod. GP532 has mutations eliminating key B- and T-cell epitopes and an inflammasome-activating domain yet remains a potent NF ...
Vadim Mett +13 more
doaj +1 more source
Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7.
PLoS Biology, 2020 Toll-like receptors (TLRs) play a crucial role in the innate immune response. Although endosomal TLR7 recognizes single-stranded RNAs, their endogenous RNA ligands have not been fully explored.
Kamlesh Pawar +3 more
doaj +1 more source
A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin [PDF]
The Journal of Experimental Medicine, 2007 The molecular basis for Toll-like receptor (TLR) recognition of microbial ligands is unknown. We demonstrate that mouse and human TLR5 discriminate between different flagellins, and we use this difference to map the flagellin recognition site on TLR5 to 228 amino acids of the extracellular domain.
Andersen-Nissen, Erica +4 more
openaire +2 more sources
Homology Modeling of Toll-Like Receptor Ligand-Binding Domains [PDF]
, 2010 Toll-like receptors (TLRs) are in the front-line during the initiation of an innate immune response against invading pathogens. TLRs are type I transmembrane proteins that are expressed on the surface of immune system cells.
Wei, Tiandi
core +1 more source
Toll-like receptor 5 as a novel receptor for fungal zymosan [PDF]
, 2021 Microbial pathogens carry specific structural patterns which were termed pathogen-associated molecular patterns (PAMPs). Toll-like receptors (TLRs) as key elements for the recognition of microbial pathogens are necessary for the activation of innate immune pathways.
Stefanie Reuter +3 more
openaire +1 more source
CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo [PDF]
, 2007 Background Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9).
Schwederski Markus +21 more
core +1 more source
Journal of Biomedical Science, 2021 Background Toll-like receptor-2 (TLR2) promotes vascular smooth muscle cell (VSMC) transdifferentiation to chondrocytes and calcification in a p38 MAPK-dependent manner.
Guan-Lin Lee +4 more
doaj +1 more source