Results 31 to 40 of about 348,116 (277)
Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis. [PDF]
Infect Immun, 2019 The Gram-negative intracellular pathogen Burkholderia pseudomallei is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential for an appropriate immune response during pathogen invasion.
Birnie E +10 more
europepmc +5 more sources
Gut Microbes, 2023 Intestinal contents comprise the largest repository of immunogenic ligands of microbial origin. We undertook this study to assess the predominant microbe-associated molecular patterns (MAMPs) present therein and the receptors) that mediate the innate ...
Matam Vijay-Kumar +6 more
doaj +1 more source
The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes [PDF]
, 2014 Peer reviewedPublisher ...
Berry, Susan +8 more
core +15 more sources
Toll‐like receptor 5 and 8 in hepatocellular carcinoma
APMIS, 2021 AbstractToll‐like receptors (TLRs) are components of innate immunity, but also have a role in carcinogenesis. The prognostic value of TLR5 and TLR8 tumor expression was examined in contrast with known risk markers Ki67 and p53. All HCC patients from Oulu University Hospital with available representative tumor sample were included in this study (n = 182)
Huhta Heikki +5 more
openaire +3 more sources
Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. [PDF]
PLoS ONE, 2016 Excessive type 2 helper T cell responses to environmental antigens can cause immunopathology such as asthma and allergy, but how such immune responses are induced remains unclear.
Linda M Lee +9 more
doaj +1 more source
3-(5-Hydroxyphenyl)-5-Phenyl-2-Pyrazolines as Toll-Like Receptor 7 Agonists
Journal of Chemistry, 2023 Toll-like receptor 7 (TLR7) is an attractive target for developing immune modulators to enhance innate immunity against ssRNA virus infections, including hepatitis C and COVID-19.
Ji Hwan Kim +5 more
doaj +1 more source
The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis. [PDF]
J Clin Biochem Nutr, 2018 Spontaneous preterm birth is often caused by chorioamnionitis. Toll-like receptors (TLRs) have a role in the response of the innate immune system. The role of TLR5 in chorioamnionitis remains unclear: however, TLR5 was reported to have a significantly stronger effect on the induction of interleukin (IL)-6 when compared with other TLRs in amniotic ...
Moroi H +13 more
europepmc +4 more sources
Evasion of Toll-like receptor 5 by flagellated bacteria [PDF]
Proceedings of the National Academy of Sciences, 2005 Toll-like receptor 5 (TLR5) recognizes an evolutionarily conserved site on bacterial flagellin that is required for flagellar filament assembly and motility. The α and ε Proteobacteria , including the important human pathogens Campylobacter jejuni ,
Andersen-Nissen, Erica +6 more
openaire +2 more sources
Egyptian Rheumatology and Rehabilitation, 2021 Background Toll-like (TLRs) play a crucial role in both adaptive and innate immunity. The aim of the present study was to assess the association of TLR5-rs5744168, TLR9-rs187084, and TLR9-rs352140 single nucleotide polymorphisms (SNPs) with ...
Ola Mohammad Gharbia +6 more
doaj +1 more source
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria [PDF]
Proceedings of the National Academy of Sciences, 2006 Toll-like receptors (TLRs) are key components of the immune system that detect microbial infection and trigger antimicrobial host defense responses. TLR5 is a sensor for monomeric flagellin, which is a component of bacterial flagella known to be a virulence factor.
Feuillet, Vincent +7 more
openaire +3 more sources