Results 11 to 20 of about 219,955 (241)

A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications [PDF]

Communications Biology, 2021
Mett et al. describe development of GP532, a substantially deimmunized derivative of Toll-like receptor 5 (TLR5) agonist entolimod. GP532 has mutations eliminating key B- and T-cell epitopes and an inflammasome-activating domain yet remains a potent NF ...
Vadim Mett, Oleg V. Kurnasov, Ivan A. Bespalov, Ivan Molodtsov, Craig M. Brackett, Lyudmila G. Burdelya, Andrei A. Purmal, Anatoli S. Gleiberman, Ilia A. Toshkov, Catherine A. Burkhart, Yakov N. Kogan, Ekaterina L. Andrianova, Andrei V. Gudkov, Andrei L. Osterman   +13 more
doaj   +2 more sources

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis. [PDF]

Infect Immun, 2019
The Gram-negative intracellular pathogen Burkholderia pseudomallei is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential for an appropriate immune response during pathogen invasion.
Birnie E, Weehuizen TAF, Lankelma JM, de Jong HK, Koh GCKW, van Lieshout MHP, Roelofs JJTH, Budding AE, de Vos AF, van der Poll T, Wiersinga WJ.   +10 more
europepmc   +5 more sources

Genetic diversity of Toll-like receptor 5 among pig populations [PDF]

Genetics and Molecular Biology, 2013
The Toll-like receptor 5 (TLR5) recognizes flagellin of Gram-positive and -negative bacteria and plays an important role in the host defense system. Here, we surveyed single nucleotide polymorphisms (SNPs) in the coding sequence of the porcine TLR5 gene ...
Xiuqin Yang, Haitao Li, Qingzhi Guan, Di Liu   +3 more
doaj   +5 more sources

Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury [PDF]

Acta Neuropathologica Communications, 2020
Microglia are the primary immune-competent cells of the central nervous system (CNS) and sense both pathogen- and host-derived factors through several receptor systems including the Toll-like receptor (TLR) family.
Masataka Ifuku, Lukas Hinkelmann, Leonard D. Kuhrt, Ibrahim E. Efe, Victor Kumbol, Alice Buonfiglioli, Christina Krüger, Philipp Jordan, Marcus Fulde, Mami Noda, Helmut Kettenmann, Seija Lehnardt   +11 more
doaj   +2 more sources

The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5. [PDF]

PLoS Pathogens, 2017
Flagellin is a wide-spread bacterial virulence factor sensed by the membrane-bound Toll-like receptor 5 (TLR5) and by the intracellular NAIP5/NLRC4 inflammasome receptor.
Vida Forstnerič, Karolina Ivičak-Kocjan, Tjaša Plaper, Roman Jerala, Mojca Benčina   +4 more
doaj   +2 more sources

The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis. [PDF]

J Clin Biochem Nutr, 2018
Spontaneous preterm birth is often caused by chorioamnionitis. Toll-like receptors (TLRs) have a role in the response of the innate immune system. The role of TLR5 in chorioamnionitis remains unclear: however, TLR5 was reported to have a significantly stronger effect on the induction of interleukin (IL)-6 when compared with other TLRs in amniotic ...
Moroi H, Kotani T, Miki R, Tsuda H, Mizuno M, Ito Y, Ushida T, Imai K, Nakano T, Li H, Sumigama S, Yamamoto E, Iwase A, Kikkawa F.   +13 more
europepmc   +4 more sources

In silico study of ligand binding site of toll-like receptor 5

Advanced Biomedical Research, 2014
Background: Toll-like receptor-5 (TLR-5) is a member of TLRs family and responsible for bacterial flagellin recognition. The activation of TLR-5 with flagellin leads to initiation of signaling cascades, which in turn results in transcription of pro ...
Nastaran Sadat Savar, Saeid Bouzari
doaj   +3 more sources

Significant abundance of bacterial flagellin and expression of its surface localized receptor toll-like receptor 5 and cytokine interleukin-22 in South African infants with poor oral rotavirus vaccine take [PDF]

Gut Pathogens
Bacterial flagellin, a potent intestinal innate immune activator, prevents murine rotavirus (RV) infection independent of adaptive immunity and interferons. The flagellin-induced immunity is mediated by Toll-like receptor (TLR5) and Nod-like receptor C4 (
Nontlantla J. Haindongo, Mapaseka Seheri, Cliff A. Magwira   +2 more
doaj   +2 more sources

Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier [PDF]

Cell Reports Medicine
Summary: The gut permeability significantly increases after ischemic stroke, partly due to disrupted mucosal barrier, but the mechanism remains elusive.
Huidi Wang, Jie Li, Guangyan Wu, Xiaofei Lin, Jiaying Chen, Jingru Liang, Jiahui Zhang, Xiaoxia Luo, Hongyun Mao, Jiahui Xie, Zhuang Li, Hongwei Zhou, Kaiyu Xu, Jia Yin, Yan He   +14 more
doaj   +2 more sources

A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin [PDF]

Journal of Experimental Medicine, 2007
The molecular basis for Toll-like receptor (TLR) recognition of microbial ligands is unknown. We demonstrate that mouse and human TLR5 discriminate between different flagellins, and we use this difference to map the flagellin recognition site on TLR5 to 228 amino acids of the extracellular domain.
Roland Strong, Kelly Smith, Richard Bonneau   +2 more
exaly   +3 more sources