Results 11 to 20 of about 16,611,336 (253)
Adaptive evolution of Toll-like receptor 5 in domesticated mammals [PDF]
BMC Evolutionary Biology, 2012 Background Previous studies have proposed that mammalian toll like receptors (TLRs) have evolved under diversifying selection due to their role in pathogen detection.
Smith Sarah A +6 more
doaj +5 more sources
Distinctive Recognition of Flagellin by Human and Mouse Toll-Like Receptor 5. [PDF]
PLoS ONE, 2016 Toll-like receptor 5 (TLR5) is a receptor of the innate immune system that recognizes flagellin from certain bacterial species and triggers an inflammatory response.
Vida Forstnerič +4 more
doaj +4 more sources
In silico study of ligand binding site of toll-like receptor 5
Advanced Biomedical Research, 2014 Background: Toll-like receptor-5 (TLR-5) is a member of TLRs family and responsible for bacterial flagellin recognition. The activation of TLR-5 with flagellin leads to initiation of signaling cascades, which in turn results in transcription of pro ...
Nastaran Sadat Savar, Saeid Bouzari
doaj +3 more sources
Charge-dependent localization of Toll-like receptor 5 at the plasma membrane
Molecules and Cells: Proper subcellular localization of Toll-like receptors (TLRs) is essential for initiating appropriate innate immune responses against pathogens while avoiding self-reactivity.
Ji-Won Huh +4 more
doaj +4 more sources
Genome-wide identification and characterization of toll-like receptor 5 (TLR5) in fishes
Frontiers in Genetics, 2023 Toll-like receptors 5 (TLR5), a member of the toll-like receptors (TLRs) family, is a class of pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs).
Kai Zhang +10 more
doaj +3 more sources
Genetic diversity of Toll-like receptor 5 among pig populations [PDF]
Genetics and Molecular Biology, 2013 The Toll-like receptor 5 (TLR5) recognizes flagellin of Gram-positive and -negative bacteria and plays an important role in the host defense system. Here, we surveyed single nucleotide polymorphisms (SNPs) in the coding sequence of the porcine TLR5 gene ...
Xiuqin Yang +3 more
doaj +5 more sources
Toll‐like receptor 5 and 8 in hepatocellular carcinoma
APMIS, 2021 AbstractToll‐like receptors (TLRs) are components of innate immunity, but also have a role in carcinogenesis. The prognostic value of TLR5 and TLR8 tumor expression was examined in contrast with known risk markers Ki67 and p53. All HCC patients from Oulu University Hospital with available representative tumor sample were included in this study (n = 182)
Huhta Heikki +5 more
openaire +3 more sources
A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1 [PDF]
, 2011 PhDAnnexin-A1 (AnxA1) is an endogenous anti-inflammatory protein that has been shown to exert a protective role against the lethal effects induced by the Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS).
Polycarpou, Anastasia
core +4 more sources
Evasion of Toll-like receptor 5 by flagellated bacteria [PDF]
Proceedings of the National Academy of Sciences, 2005 Toll-like receptor 5 (TLR5) recognizes an evolutionarily conserved site on bacterial flagellin that is required for flagellar filament assembly and motility. The α and ε Proteobacteria , including the important human pathogens Campylobacter jejuni ,
Andersen-Nissen, Erica +6 more
openaire +2 more sources
Journal of Innate Immunity, 2021 Eosinophil (Eo) degranulation plays a central role in the initiations of allergic attacks. Flagellin (FGN), the major component of bacterial flagella, has immune regulatory functions.
Xiang-Qian Luo +7 more
doaj +1 more source