Results 21 to 30 of about 348,116 (277)

A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications [PDF]

Communications Biology, 2021
Mett et al. describe development of GP532, a substantially deimmunized derivative of Toll-like receptor 5 (TLR5) agonist entolimod. GP532 has mutations eliminating key B- and T-cell epitopes and an inflammasome-activating domain yet remains a potent NF ...
Vadim Mett, Oleg V. Kurnasov, Ivan A. Bespalov, Ivan Molodtsov, Craig M. Brackett, Lyudmila G. Burdelya, Andrei A. Purmal, Anatoli S. Gleiberman, Ilia A. Toshkov, Catherine A. Burkhart, Yakov N. Kogan, Ekaterina L. Andrianova, Andrei V. Gudkov, Andrei L. Osterman   +13 more
doaj   +2 more sources

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infraorbital blood–nerve barrier following chronic constriction injury? [PDF]

Molecular Pain, 2017
Background Blood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Nathan Moreau, Annie Mauborgne, Pierre-Olivier Couraud, Ignacio A Romero, Babette B Weksler, Luis Villanueva, Michel Pohl, Yves Boucher   +7 more
doaj   +5 more sources

Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury [PDF]

Acta Neuropathologica Communications, 2020
Microglia are the primary immune-competent cells of the central nervous system (CNS) and sense both pathogen- and host-derived factors through several receptor systems including the Toll-like receptor (TLR) family.
Masataka Ifuku, Lukas Hinkelmann, Leonard D. Kuhrt, Ibrahim E. Efe, Victor Kumbol, Alice Buonfiglioli, Christina Krüger, Philipp Jordan, Marcus Fulde, Mami Noda, Helmut Kettenmann, Seija Lehnardt   +11 more
doaj   +2 more sources

The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5. [PDF]

PLoS Pathogens, 2017
Flagellin is a wide-spread bacterial virulence factor sensed by the membrane-bound Toll-like receptor 5 (TLR5) and by the intracellular NAIP5/NLRC4 inflammasome receptor.
Vida Forstnerič, Karolina Ivičak-Kocjan, Tjaša Plaper, Roman Jerala, Mojca Benčina   +4 more
doaj   +2 more sources

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol. [PDF]

Sci Rep, 2017
© 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ
Caballero I, Boyd J, Almiñana C, Sánchez-López JA, Basatvat S, Montazeri M, Maslehat Lay N, Elliott S, Spiller DG, White MR, Fazeli A.   +10 more
europepmc   +7 more sources

Significant abundance of bacterial flagellin and expression of its surface localized receptor toll-like receptor 5 and cytokine interleukin-22 in South African infants with poor oral rotavirus vaccine take [PDF]

Gut Pathogens
Bacterial flagellin, a potent intestinal innate immune activator, prevents murine rotavirus (RV) infection independent of adaptive immunity and interferons. The flagellin-induced immunity is mediated by Toll-like receptor (TLR5) and Nod-like receptor C4 (
Nontlantla J. Haindongo, Mapaseka Seheri, Cliff A. Magwira   +2 more
doaj   +2 more sources

Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier [PDF]

Cell Reports Medicine
Summary: The gut permeability significantly increases after ischemic stroke, partly due to disrupted mucosal barrier, but the mechanism remains elusive.
Huidi Wang, Jie Li, Guangyan Wu, Xiaofei Lin, Jiaying Chen, Jingru Liang, Jiahui Zhang, Xiaoxia Luo, Hongyun Mao, Jiahui Xie, Zhuang Li, Hongwei Zhou, Kaiyu Xu, Jia Yin, Yan He   +14 more
doaj   +2 more sources

Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia [PDF]

Frontiers in Immunology, 2019
Bacterial infections of the respiratory tract constitute a major cause of death worldwide. Given the constant rise in bacterial resistance to antibiotics, treatment failure is increasingly frequent.
Laura Matarazzo, Fiordiligie Casilag, Rémi Porte, Frederic Wallet, Delphine Cayet, Christelle Faveeuw, Christophe Carnoy, Jean-Claude Sirard   +7 more
doaj   +2 more sources

Exploring the mechanism of intestinal bacterial translocation after severe acute pancreatitis: the role of Toll-like receptor 5 [PDF]

Gut Microbes
Severe acute pancreatitis (SAP)-induced intestinal bacterial translocation and enterogenic infection are among the leading causes of mortality in patients.
Cheng Zhang, Shiyin Chen, Zhien Wang, Jian Zhang, Wenqiao Yu, Yanshuai Wang, Weiwei Si, Yuwei Zhang, Yun Zhang, Tingbo Liang   +9 more
doaj   +2 more sources

Genetic diversity of Toll-like receptor 5 among pig populations [PDF]

Genetics and Molecular Biology, 2013
The Toll-like receptor 5 (TLR5) recognizes flagellin of Gram-positive and -negative bacteria and plays an important role in the host defense system. Here, we surveyed single nucleotide polymorphisms (SNPs) in the coding sequence of the porcine TLR5 gene ...
Xiuqin Yang, Haitao Li, Qingzhi Guan, Di Liu   +3 more
doaj   +5 more sources