Results 21 to 30 of about 16,611,336 (253)

Toll-like receptor 5 and the emerging role of bacteria in carcinogenesis [PDF]

OncoImmunology, 2013
Toll-like receptor 5 (TLR5) is an pattern recognition receptor expressed by several cells of the immune system that recognizes bacterial flagellin. We studied the influence of TLR5 in oral tongue squamous carcinoma and found that its expression levels predict patient survival and recurrence.
Salo Tuula, Salo Tuula, Karttunen Tuomo, Salo Tuula   +3 more
openaire   +2 more sources

Clostridium butyricum Helps to Alleviate Inflammation in Weaned Piglets Challenged With Enterotoxigenic Escherichia coli K88

Frontiers in Veterinary Science, 2021
Background: Whether the probiotic Clostridium butyricum (CB) alleviates enterotoxigenic Escherichia coli (ETEC) K88-induced inflammation by regulating the activation of the toll-like receptor (TLR) signaling pathway is not clear, thus, we carried out ...
Haihua Li, Xuejiao Liu, Zhiyuan Shang, Jiayun Qiao   +3 more
doaj   +1 more source

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis [PDF]

Infection and Immunity, 2019
The Gram-negative intracellular pathogen Burkholderia pseudomallei is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential for an appropriate immune response during pathogen invasion.
Emma Birnie, Tassili A. F. Weehuizen, Jacqueline M. Lankelma, Hanna K. de Jong, Gavin C. K. W. Koh, Miriam H. P. van Lieshout, Joris J. T. H. Roelofs, Andries E. Budding, Alex F. de Vos, Tom van der Poll, W. Joost Wiersinga   +10 more
openaire   +3 more sources

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi, Forrest, A, Schroder, K, Forrest, Alistair, Kawai, J, Kawaji, H, Wells, Christine A, Faulkner, G, Carninci, P, Hume, DA, Carninci, Piero, Grimmond, SM, Himes, SR, Lo, Sandra, Hume, David, Schroder, Kate, Taylor, D, Grimmond, Sean M, Faulkner, Geoffrey, Chalk, Alistair, Kasukawa, T, Himes, S Roy, Grimmond, Sean, Kawai, Jun, Waddell, Nic, Lo, Yu-Lan Sandra, Hayashizaki, Yoshihide, Kasukawa, Takeya, Wells, Christine, Katayama, S, Hayashizaki, Y, Chalk, Alistair M, Katayama, Shintaro, Hume, David A, Chalk, AM, Taylor, Darrin, Kawaji, Hideya, Wells, CA, Waddell, N, Lo, S, Kai, C   +40 more
core   +1 more source

Pulmonary tuberculosis susceptibility and association with Toll-Like receptor 2 Arg753Gln polymorphism

Journal of Infection in Developing Countries, 2022
Introduction: Tuberculosis has been a concern of healthcare professionals due to the serious threats it poses on public health safety. However, regardless all the efforts, no appropriate goals for immunological diagnosis or tuberculosis treatment were ...
Eman A El-Masry, Ibrahim Taher, Helal F Hetta, Samy S Eldahdouh   +3 more
doaj   +1 more source

Pattern-recognition receptors in endometriosis: A narrative review

Frontiers in Immunology, 2023
Endometriosis is closely associated with ectopic focal inflammation and immunosuppressive microenvironment. Multiple types of pattern recognition receptors (PRRs) are present in the innate immune system, which are able to detect pathogen-associated ...
Bao Guo, Jia hua Chen, Jun hui Zhang, Yuan Fang, Xiao jing Liu, Jing Zhang, Hai qing Zhu, Lei Zhan   +7 more
doaj   +1 more source

Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria [PDF]

Proceedings of the National Academy of Sciences, 2006
Toll-like receptors (TLRs) are key components of the immune system that detect microbial infection and trigger antimicrobial host defense responses. TLR5 is a sensor for monomeric flagellin, which is a component of bacterial flagella known to be a virulence factor. In this study we generated TLR5-deficient mice and investigated the
Feuillet, Vincent, Medjane, Samir, Mondor, Isabelle, Demaria, Olivier, Pagni, Philippe P, Galán, Jorge E, Flavell, Richard A, Alexopoulou, Lena   +7 more
openaire   +3 more sources

Structural Study of Binding of Flagellin by Toll-Like Receptor 5 [PDF]

Journal of Bacteriology, 2003
ABSTRACTIn order to predict the binding regions within the complex formed by Toll-like receptor 5 (TLR-5) and flagellin, a complementary hydropathy between the two proteins was sought. A region common to the flagellins ofSalmonella entericaserovar Typhimurium,Pseudomonas aeruginosa, andListeria monocytogeneswas shown to be hydropathically complementary
Saul G, Jacchieri, Ricardo, Torquato, Ricardo R, Brentani   +2 more
openaire   +2 more sources

Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. [PDF]

, 2008
Despite high rates of exposure, only 5-10% of people infected with Mycobacterium tuberculosis will develop active tuberculosis (TB) disease, suggesting a significant role for genetic variation in the human immune response to this infection.
Crevel, R. van, Carine Bonnard, Hazel E E Wong, Sahiratmadja Edhyana, Wong, Hazel EE, Ottenhoff, THM, Nejentsev, S., van de Vosse, Esther, Bonnard, C, Ottenhoff, T.H., Martin L Hibberd, Jeffrey S Szeszko, Ottenhoff Tom H. M., Reinout van Crevel, Balabanova, Yanina, van Crevel Reinout, Nejentsev Sergey, Seielstad, M., Ottenhoff, Tom HM, Tom H M Ottenhoff, van Crevel, Reinout, Sahiratmadja, Edhyana, Wong, H.E., Yanina Balabanova, Szeszko Jeffrey S., Hari Dass, Ranjeeta, Alisjahbana Bachti, Szeszko, Jeffrey S, Edhyana Sahiratmadja, Bonnard, Carine, Bachti Alisjahbana, Szeszko, J.S., Francis Drobniewski, Davila, Sonia, Alisjahbana, B., Hibberd, M.L., Hari Dass, R., Balabanova, Y., Alisjahbana, Bachti, van de Vosse, E, Alisjahbana, B, Bonnard Carine, Hari Dass Ranjeeta, Sonia Davila, Ranjeeta Hari Dass, Nejentsev, S, Szeszko, JS, Nejentsev, Sergey, Davila, S, Sergey Nejentsev, Seielstad Mark, Dass, Ranjeeta Hari, van Crevel, R, Bonnard, C., Dass, RH, Hibberd Martin L., Balabanova Yanina, van de Vosse Esther, Vosse, E. van de, Mark Seielstad, Seielstad, M, Hibberd, ML, Balabanova, Y, Davila, S., Drobniewski, F, Sahiratmadja, E., Davila Sonia, Drobniewski, Francis, Seielstad, Mark, Drobniewski, F., Wong, HEE, Hibberd, Martin L, Sahiratmadja, E, Esther van de Vosse, Wong Hazel E. E., Drobniewski Francis   +75 more
core   +3 more sources

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source