Results 91 to 100 of about 537,344 (241)

Toll-Like Receptor 2 (TLR-2) Gene Polymorphisms In Type 2 Diabetes Mellitus

Cell Journal, 2018
Objective Innate immunity factors are associated with type 2 diabetes (T2DM) and its complications. Therefore, T2DM has been suggested to be an immune-dependent disease. Elevated fasting glucose level and higher concentrations of innate immunity soluble
Zeynep Ermiş Karaali, Gonca Candan, Mehmet Burak Aktuğlu, Mustafa Velet, Arzu Ergen   +4 more
doaj   +1 more source

Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance [PDF]

, 2012
INTRODUCTION Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid arthritis (RA).
Alzabin, Saba, Kong, Philip, Medghalchi, Mino, Palfreeman, Andrew, Sacre, Sandra, Williams, Richard   +5 more
core   +1 more source

Cooperative Interactions between Toll-Like Receptor 2 and Toll-Like Receptor 4 in Murine Klebsiella pneumoniae Infections

Journal of Microbiology and Biotechnology, 2017
Klebsiella pneumoniae is an opportunistic and clinically significant emerging pathogen. We investigated the relative roles of Toll-like receptor (TLR) 2 and TLR4 in initiating host defenses against K. pneumoniae. TLR2 knockout (KO), TLR4 KO, TLR2/4 double KO (DKO), and wild-type (WT) mice were inoculated with K. pneumoniae.
Hee-Yeon, Jeon, Jong-Hyung, Park, Jin-Il, Park, Jun-Young, Kim, Sun-Min, Seo, Seung-Hoon, Ham, Eui-Suk, Jeong, Yang-Kyu, Choi   +7 more
openaire   +2 more sources

The role of hypoxia and complement receptor 2 or toll-like receptor 2 on B1 B cell effector function [PDF]

Master of ScienceDivision of BiologySherry D. FlemingProfessional phagocytes play a critical role in maintaining homeostasis within a host through phagocytic, microbicidal, and inflammatory activity.
Knights, Kaori
core   +1 more source

Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNF and IFN [PDF]

, 2014
In cutaneous leishmaniasis, Leishmania amazonensis activates macrophage double-stranded, RNA-activated protein kinase R (PKR) to promote parasite growth. In our study, Leishmania major grew normally in RAW cells, RAW-expressing dominant-negative PKR (PKR-
Abu-Dayyeh I., Aislan de Carvalho Vivarini, Ana Paula C. A. Lima, Da Silva R., Danelli M. G., Jeremy C. Mottram, Marilia S. Faria, Nylen S., Tereza C. Calegari‐Silva, Ulisses Gazos Lopes, Vivarini Ade C.   +10 more
core   +1 more source

Toll-like receptor 2 confers partial neuroprotection during prion disease.

PLoS ONE, 2018
Neuroinflammation and neurodegeneration are common during prion infection, but the mechanisms that underlie these pathological features are not well understood. Several components of innate immunity, such as Toll-like receptor (TLR) 4 and Complement C1q,
James A Carroll, Brent Race, Katie Williams, Bruce Chesebro   +3 more
doaj   +1 more source

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB

Scientific Reports, 2014
Growing evidence links tumor progression with chronic inflammatory processes and dysregulated activity of various immune cells. In this study, we demonstrate that various types of macrophages internalize microvesicles, called exosomes, secreted by breast
A. Chow, Weiying Zhou, Liang Liu, M. Fong, Jackson Champer, Desiree Van Haute, Andrew R. Chin, X. Ren, B. Gugiu, Z. Meng, Wendong Huang, V. Ngo, M. Kortylewski, S. E. Wang   +13 more
semanticscholar   +1 more source

Preventing Peritoneal Dialysis-Associated Fibrosis by Therapeutic Blunting of Peritoneal Toll-Like Receptor Activity

Frontiers in Physiology, 2018
Peritoneal dialysis (PD) is an essential daily life-saving treatment for end-stage renal failure. PD therapy is limited by peritoneal inflammation, which leads to peritoneal membrane failure as a result of progressive fibrosis.
Anne-Catherine Raby, Mario O. Labéta
doaj   +1 more source

Treating Progressive Multifocal Leukoencephalopathy With Interleukin 7 and Vaccination With JC Virus Capsid Protein VP1 [PDF]

, 2017
Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as ...
Bofill-Mas, Silvia, Cinque, Paola, Croughs, Therese, Demina, Viktoria, Garcea, Robert, Girones, Rosina, Jelcic, Ilijas, Martin, Roland, Planas, Raquel, Schippling, Sven, Sospedra, Mireia, Stellmann, Jan-Patrick, Yousef, Sara   +12 more
core  

Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2.

Journal of Immunology, 1999
The agent of Lyme disease, Borrelia burgdorferi, produces membrane lipoproteins possessing potent inflammatory properties linked to disease pathology. The recent association of toll-like receptors (TLR) 2 and 4 with LPS responses prompted the examination
M. Hirschfeld, C. Kirschning, R. Schwandner, H. Wesche, J. Weis, R. M. Wooten, J. Weis   +6 more
semanticscholar   +1 more source