Results 71 to 80 of about 100,532,293 (204)

Association of Toll-like receptor 2 polymorphisms with gout

Biomedical Reports, 2014
Gout is the most common autoinflammatory arthritis characterized by elevated serum urate and recurrent attacks of intra-articular crystal deposition of monosodium urate (MSU) in tissues. The pathogenesis of gout has not been fully determined, although certain genetic factors are involved in the development of gout.
Yan, Cai, Yi-Hua, Peng, Zhong, Tang, Xiao-Lan, Guo, Yu-Feng, Qing, Su-Hua, Liang, Hong, Jiang, Wang-Tai, Dang, Qiang, Ma, Cheng, He, Jing-Guo, Zhou   +10 more
openaire   +3 more sources

Toll-Like Receptors in Neurodegeneration

, 2011
The key roles of toll-like receptors (TLRs) as mediators of the detection and responses of immune cells to invading pathogens are well known. There are at least 13 mammalian TLRs which are integral membrane proteins with a leucine- rich extracellular ...
TANG, SUNG-CHUN, 湯頌君
core   +1 more source

Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils [PDF]

, 2012
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogenic ...
Claire L Streatfield, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Streatfield, Claire L., Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Streatfield Claire L., Yasinska Inna, Sumbayev Vadim V., Inna Yasinska, Oniku Abraham E., Gibbs Bernhard F., Abraham E Oniku   +14 more
core   +2 more sources

Relationship between Arg753Gln Toll-like receptor 2 and Asp299Gly Toll-like receptor 4 genetic variations and susceptibility to colorectal cancer in Southern Iran [PDF]

Archives of Biological Sciences, 2018
Variations in Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) encoding genes have been associated with tumorigenesis through the disruption of immune and inflammatory responses.
Hosseini Seyed Vahid, Mojtahedi Zahra, Beizavi Zahra, Khazraei Hajar, Zamani Mozhdeh   +4 more
doaj   +1 more source

Toll-like receptor 2 and Toll-like receptor 4-dependent activation of B cells by a polysaccharide from marine fungus Phoma herbarum YS4108. [PDF]

PLoS ONE, 2013
Various natural polysaccharides are capable of activating the immune system and therefore can be employed as biological response modifiers in anti-tumor therapy.
Xian Zhang, Ran Ding, Yan Zhou, Rui Zhu, Wei Liu, Lei Jin, Wenbing Yao, Xiangdong Gao   +7 more
doaj   +1 more source

Rewiring of sIgM-mediated intracellular signaling through the CD180 toll-like receptor [PDF]

, 2015
Chronic Lymphocytic Leukaemia (CLL) development and progression is thought to be driven by unknown antigens/autoantigens through the B cell receptor (BCR), and environmental signals for survival and expansion including Toll-like receptor (TLR) ligands ...
Rajakaruna, N., Nino Porakishvili, Clark, Edward A., Chiorazzi, N., Tsertsvadze, T., Nina Kulikova, Rajendra N. Damle, Amit Nathwani, Porakishvili, Nino, Chiorazzi, Nicholas, Rai, K. R., Andrew J. Steele, Porakishvili, N., Rai, Kanti R., +2 additional authors, Kulikova, Nina, Tamar Tsertsvadze, Kanti R. Rai, Vispute, Ketki, Lydyard, Peter M., Nathwani, Amit, Vispute, K., Lydyard, P. M., Steele, A. J., Tsertsvadze, Tamar, Nicholas Chiorazzi, Peter M. Lydyard, Rajakaruna, Nadeeka, Steele, Andrew J., Nadeeka Rajakaruna, Kulikova, N., Damle, Rajendra N., Ketki Vispute, Edward A. Clark, Damle, R. N., Clark, E.A., Damle, R.N., Nathwani, A., Rai, K.R., Lydyard, P.M.   +39 more
core   +2 more sources

Chitin modulates innate immune responses of keratinocytes. [PDF]

, 2011
Chitin, after cellulose the second most abundant polysaccharide in nature, is an essential component of exoskeletons of crabs, shrimps and insects and protects these organisms from harsh conditions in their environment.
Korting, Hans Christian, Koller, Barbara, Thomas Ruzicka, Korting Hans Christian, Rupec Rudolph, Müller-Wiefel Alisa Sophie, Alisa Sophie Müller-Wiefel, Müller-Wiefel, Alisa Sophie, Rudolph Rupec, Koller Barbara, Hans Christian Korting, Ruzicka, Thomas, Barbara Koller, Ruzicka Thomas, Rupec, Rudolph   +14 more
core   +2 more sources

Toll-Like Receptor 2 (TLR-2) Gene Polymorphisms In Type 2 Diabetes Mellitus

Cell Journal, 2018
Objective Innate immunity factors are associated with type 2 diabetes (T2DM) and its complications. Therefore, T2DM has been suggested to be an immune-dependent disease. Elevated fasting glucose level and higher concentrations of innate immunity soluble
Zeynep Ermiş Karaali, Gonca Candan, Mehmet Burak Aktuğlu, Mustafa Velet, Arzu Ergen   +4 more
doaj   +1 more source

Toll-like receptor 2 suppresses Toll-like receptor 9 responses in Peyer's patch dendritic cells

Immunobiology, 2015
In the intestine, immune responses to commensal microbes should be regulated precisely. This regulation is achieved partly by dendritic cells (DCs), which recognize microbes through Toll-like receptors (TLRs). Although TLR responses have been intensely studied, cross-talk between individual TLRs remains unclear.
Ryutaro, Kotaki, Shun-ichi, Wajima, Aya, Shiokawa, Satoshi, Hachimura   +3 more
openaire   +2 more sources

Toll-like receptor 2 confers partial neuroprotection during prion disease.

PLoS ONE, 2018
Neuroinflammation and neurodegeneration are common during prion infection, but the mechanisms that underlie these pathological features are not well understood. Several components of innate immunity, such as Toll-like receptor (TLR) 4 and Complement C1q,
James A Carroll, Brent Race, Katie Williams, Bruce Chesebro   +3 more
doaj   +1 more source