Results 91 to 100 of about 460,890 (351)

Different routes to the same destination

eLife, 2013
The toll-like receptors that detect viral DNA and viral RNA in cells take different paths from the endoplasmic reticulum to the endosome.
Kachiko Hayashi, Akiko Iwasaki
doaj   +1 more source

Toll-like Receptor 2 Polymorphism Is Associated With Preterm Birth [PDF]

Pediatric Research, 2007
Evidence is increasing for a role of polymorphisms in maternal or fetal innate immune response genes in preterm birth. Toll-like receptors (TLRs) are important receptors in the innate immunity. The genotype distribution of two TLR2 single nucleotide polymorphisms (SNPs) and one TLR4 SNP were determined among 524 neonates and associated with gestational
Krediet, Tannette G., Wiertsema, Selma P., Vossers, Marjolein J., Hoeks, Sanne B. E. A., Fleer, Andre, Ruven, Henk J. T., Rijkers, Ger T.   +6 more
openaire   +3 more sources

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

Effects of oregano essential oil on brain TLR4 and TLR2 gene expression and depressive-like behavior in a rat model

Research in Pharmaceutical Sciences, 2018
The aim of the present study was to evaluate the effects of oregano essential oil (OEO) on the hippocampus and prefrontal cortex TLR 2/4 gene expression and depressive like behavior induced by chronic unpredictable stress (CUS).
Azam Amiresmaeili, Samira Roohollahi, Ali Mostafavi, Nayere Askari   +3 more
doaj   +1 more source

Toll-like receptor-2 and -4 are associated with hyperlipidemia

Molecular Medicine Reports, 2012
Recent studies have suggested that toll-like receptors (TLRs) contribute to insulin resistance, and that fatty acids have a role in TLR activation. Other studies have found that TLR2 and TLR4 upregulation is consistent with an increase in serum lipid. Therefore, it was hypothesized that TLRs are associated with hyperlipidemia.
Ya-Jun, Zhu, Chao, Wang, Guangyao, Song, Sha-Sha, Zang, Yi-Xuan, Liu, Ling, Li   +5 more
openaire   +3 more sources

Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages

, 2002
During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products.
Sweet, Matthew J, Foo Y. Liew, Sester, David P, Katryn J. Stacey, Xu, Damo, David P. Sester, Rebecca C. McDonald, David A. Hume, McDonald, Rebecca C, Campbell, Carol C, Stacey, Katryn J, Hume, David A, Liew, Foo Y, Matthew J. Sweet, Carol C. Campbell, Damo Xu   +15 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies

Frontiers in Pharmacology, 2018
The innate immune response in the central nervous system (CNS) is implicated as both beneficial and detrimental to health. Integral to this process are microglia, the resident immune cells of the CNS.
Ian F Caplan, K. Maguire-Zeiss
semanticscholar   +1 more source

Innate immune activation in experimental autoimmune myocarditis [PDF]

, 2007
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and frequently results from postinfectious autoimmunity. Its pathophysiology is modeled by experimental autoimmune myocarditis (EAM), a CD4+ T-cell mediated murine model of ...
Marty, René Roger
core   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source