Results 101 to 110 of about 537,344 (241)

Leishmania braziliensis Infection Enhances Toll-Like Receptors 2 and 4 Expression and Triggers TNF-α and IL-10 Production in Human Cutaneous Leishmaniasis

Frontiers in Cellular and Infection Microbiology, 2019
Cutaneous leishmaniasis (CL) caused by infection with Leishmania braziliensis is characterized by an exaggerated inflammatory response that controls the parasite burden, but also contributes to pathology. While myeloid cells are required to eliminate the
Ludmila P. Polari, Pedro Paulo Carneiro, Pedro Paulo Carneiro, Michael Macedo, Paulo R. L. Machado, Paulo R. L. Machado, Phillip Scott, Edgar M. Carvalho, Edgar M. Carvalho, Olívia Bacellar, Olívia Bacellar   +10 more
doaj   +1 more source

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

Nature Immunology, 2009
Despite the paradigm that the innate immune system uses nucleic acid–specific receptors to detect viruses because of a lack of other conserved features, many viruses are recognized by Toll-like receptor 2 (TLR2) and TLR4.
Roman Barbalat, Laura Lau, R. Locksley, G. Barton   +3 more
semanticscholar   +1 more source

Toll-like receptor 2: therapeutic target for gastric carcinogenesis

Oncotarget, 2012
Gastric cancer is the second most lethal cancer world-wide, and has a poor overall 5-year survival rate of
William, McCormack, Masanobu, Oshima, Patrick, Tan, Brendan, Jenkins   +3 more
openaire   +3 more sources

The Role of Toll-Like Receptor 2 and 4 Innate Immunity Pathways in Intracortical Microelectrode-Induced Neuroinflammation

Frontiers in Bioengineering and Biotechnology, 2018
We have recently demonstrated that partial inhibition of the cluster of differentiation 14 (CD14) innate immunity co-receptor pathway improves the long-term performance of intracortical microelectrodes better than complete inhibition.
John K. Hermann, John K. Hermann, Shushen Lin, Shushen Lin, Arielle Soffer, Arielle Soffer, Chun Wong, Chun Wong, Vishnupriya Srivastava, Vishnupriya Srivastava, Jeremy Chang, Jeremy Chang, Smrithi Sunil, Smrithi Sunil, Shruti Sudhakar, Shruti Sudhakar, William H. Tomaszewski, William H. Tomaszewski, Grace Protasiewicz, Grace Protasiewicz, Stephen M. Selkirk, Stephen M. Selkirk, Stephen M. Selkirk, Robert H. Miller, Jeffrey R. Capadona, Jeffrey R. Capadona   +25 more
doaj   +1 more source

Keratinocytes from human skin respond as typical immune cells after the stimulation with _Trichophyton rubrum_ [PDF]

, 2007
_Trichophyton rubrum_ is the main agent causing dermatophytosis (1). Keratinocytes are considered to be the first physical barrier of defense against pathogens (2). But not only a physical barrier.
Alfonso E. Islas-Rodrí, Luz A. Garcí   +1 more
core   +1 more source

B Cell Activation in Insulin Resistance and Obesity [PDF]

, 2011
Our group has demonstrated that inflammatory diseases such as type 2 diabetes (DM), inflammatory bowel disease (IBD), and periodontal disease (PD) are associated with altered B cell function that may contribute to disease pathogenesis. B cells were found
Apovian, Caroline, Ganley-Leal, Lisa, Gokce, Noyan, Liang, YanMei, McDonnell, Marie, Mehta, Ankeeta, Zhang, Jeanette   +6 more
core   +1 more source

Toll-Like receptors-2 and-4 levels in streptozotocin-induced diabetic Wistar rats

Sokoto Journal of Medical Laboratory Science, 2023
Diabetes is a multifactorial metabolic disorder that leads to complications. Hyperglycaemia induced inflammation is central in diabetes complications. TLR2 and TLR4 initiate and propagate persistent inflammation in diabetes.
Chiroma Fatima Aliyu , Chiwar Hassan Musa , Usman Yahaya , Dallatu Muhammed Kabiru , Abubakar Ibrahim Anka , Haruna Shamsuddeen , Ibrahim Yakubu , Akuyam Shehu Abubakar
doaj  

Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection [PDF]

, 2008
Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which causes altered responsiveness to the bacterial pathogens.
Ivan Mikula Jr., Ivan Mikula Sr., Lucia Kisova, Mangesh Bhide, Michal Novak, Rastislav Mucha, Rostislav Skrabana   +6 more
core   +1 more source

Interleukin-1/Toll-like receptor signaling potentiates macrophage olfactory receptor 2-driven atherosclerosis

Cell Reports
Summary: Olfactory receptor 6A2 (OR6A2) signaling stimulates atherogenic NLRP3 inflammasome activation in vascular macrophages (Mϕs). Current evidence suggests that interleukin-1 receptor type 1 (IL-1R1)/Toll-like receptor (TLR) signaling may modulate ...
Lujun Zhang, Jili Fu, Zicheng Hu, Yunli Zhao, Yu Cao, Mengyu Yao, Fan Liu, Jianlin Du, Haitao Ran, Zhigang Wang, Yongyong Li, Liwen Liang, Wenhua Su, Narayan D. Melgiri, Dongfang Liu, Lihong Jiang, Tianyang Hu, Rongzhong Huang, Yang Sun   +18 more
doaj   +1 more source

TLR-9 Expression in Human Bronchial Epithelial Cells induced with Lipopolysaccharide [PDF]

, 2010
The study conducted here was to investigate the gene and protein expression of Toll like receptor 9 when human bronchial epithelial cells were induced by lipopolysaccharide.
Sangeetha Dharmalingam, Shanmuga Saravanabhavan   +1 more
core   +1 more source