Results 11 to 20 of about 363,419 (348)
Toll-like Receptor 2 in Autoimmune Inflammation
Immune Network, 2021 TLR signaling is critical for broad scale immune recognition of pathogens and/or danger molecules. TLRs are particularly important for the activation and the maturation of cells comprising the innate immune response. In recent years it has become apparent that several different TLRs regulate the function of lymphocytes as well, albeit to a lesser ...
Kathryne E. Marks +3 more
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Critical Care Explorations, 2021 OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD +5 more
doaj +1 more source
Toll-like receptor 2 signalling and inflammation [PDF]
Annals of the Rheumatic Diseases, 2005 Toll-like receptors (TLRs) are a family of proteins that are involved in the initial phase of host defence against invading pathogens. TLRs act as primary sensors of microbial products and activate signalling pathways that lead to the induction of immune and inflammatory genes.1 TLRs belong to a broader family of proteins, which include receptors for ...
F Y, Liew, M, Patel, D, Xu
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Herpesviral infection and Toll-like receptor 2 [PDF]
Protein & Cell, 2012 In the last decade, substantial progress has been made in understanding the molecular mechanisms involved in the initial host responses to viral infections. Herpesviral infections can provoke an inflammatory cytokine response, however, the innate pathogen-sensing mechanisms that transduce the signal for this response are poorly understood.
Ming-sheng, Cai +2 more
openaire +2 more sources
Journal of Infection in Developing Countries, 2022 Introduction: Tuberculosis has been a concern of healthcare professionals due to the serious threats it poses on public health safety. However, regardless all the efforts, no appropriate goals for immunological diagnosis or tuberculosis treatment were ...
Eman A El-Masry +3 more
doaj +1 more source
AhR Regulates Peptidoglycan-Induced Inflammatory Gene Expression in Human Keratinocytes
Journal of Innate Immunity, 2021 Bacterial peptidoglycan (PGN) stimulates toll-like receptor 2 (TLR2) on the surface of keratinocytes (KCs), triggering signaling pathways that promote an innate immune response.
Lanqi Wang +3 more
doaj +1 more source
Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer [PDF]
Immunity, 2009 Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA complexes.
Kang, JY Kang, Jin Young +9 more
openaire +3 more sources
Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection [PDF]
, 2003 Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection.
Bryant, Clare E +4 more
core +2 more sources
Identification of single nucleotide polymorphisms in Toll-like receptor candidate genes associated with tuberculosis infection in water buffalo (Bubalus bubalis) [PDF]
, 2014 Toll-like receptors play a key role in innate immunity by recognizing pathogens and activating appropriate responses. Pathogens express several signal molecules (pathogen-associated molecular patterns, PAMPs) essential for survival and pathogenicity ...
Acutis, Pier Luigi +11 more
core +1 more source
Toll-like receptor (TLR) 2 and TLR4 gene expression in canine heart [PDF]
, 2007 Toll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic.
Blecha, Frank +2 more
core +2 more sources