Results 301 to 310 of about 363,419 (348)

Programmatic regulation of macrophage polarization by HAp@MXene nanocomposites to promote bone repair

BMEMat, EarlyView.
HAp@MXene nanocomposites could achieve the programmed regulation of macrophage polarization. They first induce M1 polarization through magnetoelectric induction to combat infection. Subsequently, controlled Ca2+ release drives M2 polarization to promote tissue regeneration. This dual mechanism accelerates bone defect repair and highlights the potential
Laisen Cui, Haina Huang, Yubo Zheng, Jiahao Zhang, Han Hai, Kai Bian, Zhichao Feng, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Shan Lu, Bojun Xie, Ke Gao, Benjie Wei, Ya Liu, Chunhui Sun, Hong Liu, Chao Liu   +16 more
wiley   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Salmonella Typhi serine threonine kinase T4519 induces lysosomal membrane permeabilization by manipulating Toll-like receptor 2-Cystatin B-Cathepsin B-NF-κB-reactive oxygen species pathway and promotes survival within human macrophages. [PDF]

PLoS Pathog
Chakraborty S, Ganguli D, Nagaraja T, Gope A, Dey S, Pal A, Mandal RS, Das SS, Das S.   +8 more
europepmc   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Insights into the Correlation between Toll-Like Receptor 2 Polymorphism and HBV-Related Disease Progression and Occurrence of Hepatocellular Carcinoma: A Case-Control Study in Egyptian Patients. [PDF]

Can J Infect Dis Med Microbiol
Elabd NS, Helal ML, Elkhayat M, Abd-ElKhalek HK, Ahmed DM, El-Shemy AM, Elsaadawy YS, Abdelmoneum RA, AboShabaan HS, Seddik RM.   +9 more
europepmc   +1 more source

A Family of Cyclic Lipopeptides Found in Human Isolates of Bacillus Ameliorates Acute Colitis via Direct Agonism of Toll-Like Receptor 2 in a Murine Model of Inflammatory Bowel Disease. [PDF]

Dig Dis Sci
Horwell E, Vittoria M, Hong HA, Bearn P, Cutting SM.   +4 more
europepmc   +1 more source

Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1. [PDF]

J Extracell Vesicles
Kim HY, Lim Y, Jang JS, Ko YK, Choi Y, Kim HH, Choi BK.   +6 more
europepmc   +1 more source

Figure 1 from Intraoperative Guidance of Pancreatic Cancer Resection Using a Toll-like Receptor 2–Targeted Fluorescence Molecular Imaging Agent

Amanda S. Huynh, Allison S. Cohen, Michael Doligalski, Todd J. Casagni, Valerie E. Moberg, Xuan Huang, Jennifer Morse, Dominique Abrahams, Mark C. Lloyd, Barbara A. Centeno, Margaret K. Baldwin, Mark L. McLaughlin, Josef Vágner, David L. Morse   +13 more
openalex   +1 more source

Expression of toll-like receptors in cartilage endplates cells: a role of toll-like receptor 2 in pro-inflammatory and -catabolic gene expression

Mengis T, Bernhard L, Herger N, Heggli I, Devan J, Marcus R, Laux C, Brunner F, Farshad M, Distler O, Dudli S.   +10 more
europepmc   +1 more source