Results 311 to 320 of about 363,419 (348)

Toll-like Receptor 2 and Toll-like Receptor 4 Expression in Human Adrenals

Hormone and Metabolic Research, 2004
Toll-like receptors (TLRs) are key elements in the innate immune response, functioning as pattern-recognition receptors for the detection and response to endotoxins and other microbial ligands. Inflammatory cytokines play an important role in the activation of the hypothalamic-pituitary-adrenal HPA axis during inflammation and sepsis.
Bornstein, SR, Schumann, RR, Rettori, V, McCann, SM, Zacharowski, KD   +4 more
openaire   +3 more sources

Toll-like receptor 2 signaling in liver pathophysiology

Life Sciences, 2021
Chronic liver diseases (CLD) are among the major cause of mortality and morbidity worldwide. Despite current achievements in the area of hepatitis virus, chronic alcohol abuse and high-fat diet are still fueling an epidemic of severe liver disease, for which, an effective therapy has yet not been discovered. In particular, the therapeutic regimens that
Anteneh, Getachew, Muzammal, Hussain, Xinping, Huang, Yinxiong, Li   +3 more
openaire   +2 more sources

Simple synthetic toll-like receptor 2 ligands

Bioorganic & Medicinal Chemistry Letters, 2011
Stimulation of toll-like receptor 2 (TLR2) by bacterial lipoproteins induces fast non-specific immune responses against pathogens followed by slow but specific adaptive immune responses. Development of synthetic TLR2 agonists/antagonists would be useful in the prevention of different infectious and immunologic disorders.
Abdel-Aal, Abu-Baker M., Al-Isae, Kalifa, Zaman, Mehfuz, Toth, Istvan   +3 more
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The Toll of Toll-Like Receptors, Especially Toll-Like Receptor 2, on Murine Atherosclerosis

Current Drug Targets, 2007
At one time, atherosclerosis was thought to be a simple lipid storage disease. However, it is now recognized as a chronic and progressive inflammation of the arterial wall. Gene deletion experiments in murine models of atherosclerosis that reduce the inflammatory process also reduce disease severity.
L K, Curtiss, P S, Tobias
openaire   +2 more sources

Expression of Toll-like Receptor 2 and Toll-like Receptor 4 in Tuberculous Pleural Effusion

Medicinal Chemistry, 2017
Toll-like receptor-2 (TLR2) and Toll-like receptor-4 (TLR4) have been reported to play a crucial role in tuberculosis, however, little is known about their expression in tuberculous pleuritis.The goal of this work is to explore the expressions of TLR2 and TLR4 in tuberculous pleuritis and their predominant expressions on cells.Levels of soluble TLR2 ...
Yingzhong, Lin, Tingmei, Feng, Jiao, Lan, Chunxia, Chen, Zhiqiang, Qin, Yanbin, Wu, Huanzhong, Shi, Jianbo, Ye, Caizhou, Wei, Wu, Wang, Luying, Huang   +10 more
openaire   +2 more sources

Toll‐like Receptor‐2 and Toll‐like Receptor‐4 Expression on Maternal Neutrophils During Pregnancy

American Journal of Reproductive Immunology, 2010
Nitsche JF, Jiang S‐W, Brost BC. Toll‐like receptor‐2 and toll‐like receptor‐4 expression on maternal neutrophils during pregnancy. Am J Reprod Immunol 2010; 64: 427–434Problem  Toll‐like receptors (TLR) are an important part of the innate immune system and are present in a variety of human tissues.
Joshua F, Nitsche, Shi-Wen, Jiang, Brian C, Brost   +2 more
openaire   +2 more sources

Comparative fine maps of bovine toll-like receptor 4 and toll-like receptor 2 regions

Mammalian Genome, 2003
Toll-like receptors are cell-surface receptors that activate innate and adaptive immune responses. We have used a 5000-rad, whole-genome radiation hybrid panel to map Toll-like receptor 4 (TLR4) to the distal end of bovine Chromosome (Chr) 8, and Toll-like receptor 2 (TLR2) to the proximal end of bovine Chr 17.
Stephen N, White, Srinivas R, Kata, James E, Womack   +2 more
openaire   +2 more sources

Toll-Like Receptor 2 and Renal Allograft Function

American Journal of Nephrology, 2008
<i>Background:</i> Toll-like receptors (TLR) modulate the immune response. We analyzed the relationships between TLR expression in renal tissue with infection, rejection and graft function after kidney transplantation. <i>Methods:</i> TLR-2 and TLR-4 expression was detected by immunohistochemistry in 257 protocol biopsies ...
Kirsten, de Groot, Katharina, Kuklik, Verena, Bröcker, Anke, Schwarz, Wilfried, Gwinner, Hans, Kreipe, Hermann, Haller, Danilo, Fliser, Michael, Mengel   +8 more
openaire   +2 more sources

Salivary and Plasma Levels of Toll‐Like Receptor 2 and Toll‐Like Receptor 4 in Chronic Periodontitis

Journal of Periodontology, 2011
Background: This cross‐sectional study was planned to investigate whether patients with chronic periodontitis exhibit different salivary or plasma concentrations of Toll‐like receptor (TLR) 2 and TLR4 compared to subjects who are clinically healthy.Methods: Whole saliva and plasma samples were obtained and full‐mouth clinical periodontal measurements ...
Buduneli, Nurcan, Ozcaka, Ozgun, Nalbantsoy, Ayse   +2 more
openaire   +3 more sources

Decreased Toll-Like Receptor 2 and Toll-Like Receptor 7/8-Induced Cytokines in Parkinson's Disease Patients

Neuroimmunomodulation, 2016
<b><i>Objectives:</i></b> Toll-like receptors (TLRs) are expressed in several immune cells including blood monocytes and resident macrophages, such as microglia in the central nervous system. TLRs recognize pathogen- or damage-associated molecular patterns, leading to the release of inflammatory and toxic molecules, which can ...
Delson José, da Silva, Arissa Felipe, Borges, Priscila Oliveira, Souza, Patrícia Reis, de Souza, Cristina Ribeiro de Barros, Cardoso, Miriam Leandro, Dorta, Milton Adriano Pelli, de Oliveira, Antônio Lúcio, Teixeira, Fátima, Ribeiro-Dias   +8 more
openaire   +2 more sources