Results 41 to 50 of about 537,344 (241)

Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer [PDF]

, 2013
OBJECTIVES: Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy.
Almeida, Joaquim Soares de, Bueno, Valquiria, Gomes, Guiomar Nascimento, Hirata, Aparecida Emiko, Teixeira, Daniela, Visniauskas, Bruna   +5 more
core   +5 more sources

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +2 more sources

K63-Linked Polyubiquitination on TRAF6 Regulates LPS-Mediated MAPK Activation, Cytokine Production, and Bacterial Clearance in Toll-Like Receptor 7/8 Primed Murine Macrophages

Frontiers in Immunology, 2018
Post viral infection bacterial pneumonia is a major cause of morbidity and mortality associated with both seasonal and pandemic influenza virus illness.
Jaya Talreja, Lobelia Samavati, Lobelia Samavati   +2 more
doaj   +1 more source

Polymorphisms of toll-like receptor 2 and 4 genes in Chagas disease

Memorias do Instituto Oswaldo Cruz, 2008
The aim of this study was to test the possible implication of toll-like receptor 2 (TLR2) and TLR4 gene polymorphisms in determining the susceptibility to Chagas' disease. Genotypes were determined by polymerase chain reaction-restriction fragment length
German Zafra, Oscar Flórez, Carlos A. Morillo, Luis Eduardo Echeverría, Javier Martín, Clara Isabel González   +5 more
doaj   +1 more source

The expression of TLR2 and TLR4 in the kidneys and heart of mice infected with Acanthamoeba spp.

Parasites & Vectors, 2020
Background Acanthamoeba spp. are cosmopolitan protozoans that cause infections in the brain, as well as extracerebral infections in the cornea, lungs and skin.
Karolina Kot, Danuta Kosik-Bogacka, Agnieszka Wojtkowiak-Giera, Agnieszka Kolasa-Wołosiuk, Natalia Łanocha-Arendarczyk   +4 more
doaj   +1 more source

Evaluation of toll-like receptors 2 and 4 polymorphism and intestinal microbiota in children with food allergies

The Turkish Journal of Pediatrics, 2023
Background. Mutual regulation between immune system and gut microbiota is achieved through several mechanisms including the engagement of toll-like receptors (TLRs) which is expressed on numerous cell types.
Mehmet Kılıç, Elif Beyazıt, Ebru Etem Önalan, Tuğçe Kaymaz, Erdal Taşkın   +4 more
doaj   +1 more source

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

Journal of Experimental Medicine, 1998
Bacterial lipopolysaccharide (LPS) induces activation of the transcription factor nuclear factor κB (NF-κB) in host cells upon infection. LPS binds to the glycosylphosphatidylinositol (GPI)- anchored membrane protein CD14, which lacks an intracellular ...
C. Kirschning, H. Wesche, T. Merrill Ayres, M. Rothe   +3 more
semanticscholar   +1 more source

Toll-like Receptor 2 and 4 (TLR2 and TLR4) Agonists Differentially Regulate Secretory Interleukin-1 Receptor Antagonist Gene Expression in Macrophages [PDF]

, 2002
Treatment of macrophages with lipopolysaccharide (LPS) from Gram-negative bacteria or peptidoglycan (PGN) from Gram-positive bacteria activates multiple intracellular signaling pathways and a large, diverse group of nuclear transcription factors.
Brown-Steinke, K., Carl, V.S., Nicklin, M.J.H., Smith, M.F.   +3 more
core   +1 more source

Expression of Toll-like receptor (TLR) 2 and TLR4 in the livers of mice infected by Clonorchis sinensis

Journal of Infection in Developing Countries, 2015
Introduction: Clonorchis sinensis is one of the most important foodborne pathogens in humans, and can cause biliary diseases such as gallstones, cholecystitis, cholangitis, and cholangiocarcinoma.
Chao Yan, Xiang-Yang Li, Bo Li, Bei-Bei Zhang, Jiang-Tao Xu, Hui Hua, Qian Yu, Zhuan-Zhuan Liu, Lin-Lin Fu, Ren-Xian Tang, Kui-Yang Zheng   +10 more
doaj   +1 more source

TLR‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis

Jornal de Pediatria (Versão em Português), 2014
Objective: To analyze toll‐like receptor (TLR)‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis. Methods: This prospective study included 27 full‐term newborns aged 8 to 29 days, with clinical and laboratory diagnosis of late‐onset ...
Ana C.C. Redondo, Maria E.J.R. Ceccon, Ana L. Silveira‐Lessa, Camila Quinello, Patrícia Palmeira, Werther B. Carvalho, Magda Carneiro‐Sampaio   +6 more
doaj   +3 more sources