Results 51 to 60 of about 363,419 (348)

Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6 [PDF]

, 2011
The Toll/interleukin-1 receptor (TIR) domain is a protein-protein interaction domain that is found in both animal and plant immune receptors. In animal Toll-like receptor signalling, both homotypic TIR-domain interactions between two receptor molecules ...
Dodds, Peter N., Ellis, Jeffrey G., Kobe, Bostjan, Valkov, Eugene, Ve, Thomas, Williams, Simon   +5 more
core   +1 more source

Bacterial Lipopolysaccharide Activates Toll-Like Receptor 2 and Toll-Like Receptor 4 Gene Expression in PBMC of Vechur Cattle

International Journal of Bio-Resource and Stress Management, 2021
Vechur cattle, an indigenous breed of Kerala and it is the smallest cattle breed in the world. They are highly disease resistant. The occurrence of mastitis is very Rare in this breed as compared to crossbred cattle.
R. Lakshmi, K. K. Jayavardhanan, J. Thanislass, P. Visha   +3 more
doaj  

Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis

BMC Gastroenterology, 2010
Background Previously we reported that mice deficient in toll-like receptor 4 (TLR-4) signalling were protected from diet-induced non-alcoholic steatohepatitis (NASH).
Brady Kristen, Pang Jia, Allman Monique, Gaskin LaTausha, Rivera Chantal A, Adegboyega Patrick, Pruitt Kevin   +6 more
doaj   +1 more source

G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes. [PDF]

, 2017
Background:Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA).
Agak, George W, Garbán, Hermes J, Hisaw, Lisa D, Kao, Stephanie, Kim, Jenny, Liu, Philip T, Marinelli, Laura J, Park, Andrew J, Pirouz, Aslan, Qin, Min, Thiboutot, Diane   +10 more
core   +1 more source

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Bovine Viral Diarrhea Virus Type 2 Impairs Macrophage Responsiveness to Toll-Like Receptor Ligation with the Exception of Toll-Like Receptor 7. [PDF]

PLoS ONE, 2016
Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family. BVDV isolates are classified into two biotypes based on the development of cytopathic (cp) or non-cytopathic (ncp) effects in epithelial cell culture.
Robert G Schaut, Julia F Ridpath, Randy E Sacco   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Randomized controlled trial of vitamin d supplementation on toll-like receptor-2 (tlr-2) and toll-like receptor-4 (tlr-4) in tuberculosis spondylitis patients

Journal of Orthopaedic Surgery and Research, 2023
Background Tuberculosis spondylitis accounts for approximately 50% of all cases of skeletal tuberculosis. Vitamin D plays a role in the immune system. Vitamin D helps in the activation of TLR-2 and TLR-4, which play a role in the process of tuberculosis ...
Jainal Arifin, Muhammad Nasrum Massi, Karya Triko Biakto, Agussalim Bukhari, Zairin Noor, Muhammad Phetrus Johan   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation [PDF]

, 2013
Inflammasomes have emerged as playing key roles in inflammation and innate immunity. A growing body of evidence has suggested that the nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasomeisimportant inchronic airwaydiseases ...
Alkhouri, H, Ammit, AJ, Bunge, K, Hirota, JA, Im, H, Manetsch, M, Oliver, BG, Pascoe, CD, Rahman, MM, Rumzhum, NN   +9 more
core   +1 more source