Results 71 to 80 of about 537,344 (241)
Tumor Biology, 2017 High mobility group box 1 and toll-like receptor 4/myeloid differentiation factor 88 signaling pathway have been indicated to have oncogenic effects in many cancers.
Yanqiu Yue +8 more
doaj +1 more source
, 2018 Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core +2 more sources
Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
Nature Communications, 2016 Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the orchestration of inflammation and sepsis but its role appears to vary for ...
Dennis Hanzelmann +10 more
semanticscholar +1 more source
UNC93B1 mediates differential trafficking of endosomal TLRs
eLife, 2013 UNC93B1, a multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes.
Bettina L Lee +6 more
doaj +1 more source
Validity of serum Toll-like receptor-2 (TLR-2) in women with breast tumor
مجلة كلية الطب, 2013 Background: Toll-like receptor -2 (TLR-2)play important roles in tumor biology; by activation and promotion of tumor cell proliferation, resistance to apoptosis andalso, enhancement of tumor cell invasion and metastasis by regulating metalloproteinase ...
Hind H. Al-Ammiri, Aida R. Al-Derzi
doaj +1 more source
An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2
bioRxiv, 2017 Pain is the predominant symptom of osteoarthritis, but the connection between joint damage and the genesis of pain is not well understood. Loss of articular cartilage is a hallmark of osteoarthritis, and it occurs through enzymatic degradation of ...
Rachel E. Miller +7 more
semanticscholar +1 more source
Histoplasma capsulatum yeast phase-specific protein Yps3p induces Toll-like receptor 2 signaling [PDF]
, 2008 Histoplasma capsulatum is a common cause of fungal infection in certain geographic areas, and although most infections are asymptomatic, it is capable of causing histoplasmosis, a disseminated, life-threatening disease, especially in immunocompromised ...
Rajagopal N Aravalli +3 more
core +2 more sources
Different routes to the same destination
eLife, 2013 The toll-like receptors that detect viral DNA and viral RNA in cells take different paths from the endoplasmic reticulum to the endosome.
Kachiko Hayashi, Akiko Iwasaki
doaj +1 more source
Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]
, 2016 Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui +2 more
core +2 more sources
Research in Pharmaceutical Sciences, 2018 The aim of the present study was to evaluate the effects of oregano essential oil (OEO) on the hippocampus and prefrontal cortex TLR 2/4 gene expression and depressive like behavior induced by chronic unpredictable stress (CUS).
Azam Amiresmaeili +3 more
doaj +1 more source