Results 1 to 10 of about 347,248 (305)
Role of Toll Like Receptor 4 in Alzheimer’s Disease
Frontiers in Immunology, 2020 Long-term evidence has confirmed the involvement of an inflammatory component in neurodegenerative disorders including Alzheimer’s disease (AD). This view is supported, in part, by data suggesting that selected non-steroidal anti-inflammatory drugs ...
Maria Calvo-Rodriguez +4 more
doaj +2 more sources
Nature Communications, 2019 The enzyme nicotinate phosphoribosyltransferase (NAPRT) mediates the rate-limiting step in NAD salvage pathway starting from nicotinic acid. Here the authors show that NAPRT can be detected extracellularly, binds to Toll like receptor 4, and activates NF-
Antonella Managò +16 more
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Toll-like receptor 4 deficiency impairs motor coordination. [PDF]
Frontiers in Neuroscience, 2016 The cerebellum plays an essential role in balance and motor coordination. Purkinje cells (PCs) are the sole output neurons of the cerebellar cortex and are critical for the execution of its functions, including motor coordination.
Jianwei eZhu +4 more
doaj +3 more sources
Toll-like Receptor 4 in Acute Kidney Injury
International Journal of Molecular Sciences, 2023 Acute kidney injury (AKI) is a common and devastating pathologic condition, associated with considerable high morbidity and mortality. Although significant breakthroughs have been made in recent years, to this day no effective pharmacological therapies ...
P. Vallés +5 more
semanticscholar +4 more sources
Toll-like receptor-4 modulation for cancer immunotherapy [PDF]
Frontiers in Immunology, 2014 Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition molecules. Since the discovery of the Toll pathway cascade (1, 2), our knowledge about the structure, function, and mechanics of TLRs in infectious and inflammatory conditions has increased remarkably. The role of TLR4 as a pathogen-pattern recognition receptor has been studied
Shanjana eAwasthi
doaj +3 more sources
Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4
Immunology, 2004 SummaryAn understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS – Toll‐like receptor 4
E. Palsson-McDermott, L. O’Neill
semanticscholar +6 more sources
Toll-Like Receptor 4 Signaling and Drug Addiction [PDF]
Frontiers in Pharmacology, 2020 The emphasis of neuronal alterations and adaptations have long been the main focus of the studies of the mechanistic underpinnings of drug addiction. Recent studies have begun to appreciate the role of innate immune system, especially toll-like receptor ...
Ruyan Wu, Ruyan Wu, Jun-Xu Li
doaj +3 more sources
How Toll-like receptors influence Parkinson’s disease in the microbiome–gut–brain axis
Frontiers in Immunology, 2023 Recently, a large number of experimenters have found that the pathogenesis of Parkinson’s disease may be related to the gut microbiome and proposed the microbiome–gut–brain axis.
Ziyi Zhang +4 more
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Toll‐like receptor 4 in atherosclerosis [PDF]
Journal of Cellular and Molecular Medicine, 2007 Introduction Toll‐like receptor 4 structure and its functions TLR4 expression in atherosclerotic lesions Endothelial cells Vascular smooth muscle cells (VSMCs) Adventitial fibroblasts Dendritic cells (DCs) Macrophages Role of TLR4 in atherosclerosis TLR4 in early atherosclerotic lesion TLR4 in advanced atherosclerotic lesion TLR4 in plaque rupture ...
Li, Hongli, Sun, Baogui
openaire +2 more sources
Critical Care Explorations, 2021 OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD +5 more
doaj +1 more source