Results 11 to 20 of about 347,248 (305)
Efficient of Toll‐Like Receptor 4 Knockout in Mouse Zygotes by CRISPER/Cas9
Novelty in Biomedicine, 2021 Background: Transgenic animals are genetically modified animals to create a specific trait that imitates an indication of pathogenesis in humans.
Delsuz Rezaee +3 more
doaj +1 more source
Toll-like receptor 4: A potential therapeutic target for multiple human diseases.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 The immune response plays a pivotal role in the pathogenesis of diseases. Toll-like receptor 4 (TLR4), as an intrinsic immune receptor, exhibits widespread in vivo expression and its dysregulation significantly contributes to the onset of various ...
Jin-rui Wei +4 more
semanticscholar +1 more source
Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells [PDF]
European Journal of Immunology, 2002 Toll-like receptor 4 (TLR4) is the signal-transducing component of the LPS recognition complex and is essential for LPS-induced septic shock. Here we demonstrate that TLR1 has the capacity to abrogate TLR4 signaling. Human microvascular endothelial cells express TLR4 but not TLR1 and respond to LPS through TLR4. The ability of these cells to respond to
Jessica H, Spitzer +4 more
openaire +2 more sources
Toll-like receptor 4 (TLR4): new insight immune and aging
Immunity & Ageing, 2023 TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands, initiating intricate intracellular ...
Hyo-Jin Kim +3 more
semanticscholar +1 more source
Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk. [PDF]
PLoS ONE, 2015 Toll-like receptor 4 is a part of the innate immune system and recognizes Helicobacter pylori lipopolysaccharide. The goal of this study was to analyze the role of Toll-like receptor 4 polymorphisms +896 (rs4986790) and +1196 (rs4986791) in the ...
Vesa-Matti Pohjanen +11 more
doaj +1 more source
Medical Journal of Babylon, 2023 Background and Objectives: This study aimed to examine the levels of the toll-like receptors TLR4 and TLR2 in the blood and saliva of patients with coronavirus disease-2019 (COVID-19) receiving orthodontic care in Babylon Province. Materials and Methods:
Basma Abdel Khaleq Eidan +2 more
doaj +1 more source
MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4
Journal of Experimental Medicine, 1999 Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens.
Rintaro Shimazu +6 more
semanticscholar +1 more source
Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction*
Journal of Biological Chemistry, 1999 TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been putatively identified as Lps, the gene necessary for potent responses to lipopolysaccharide in mammals.
Jesse C. Chow +4 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Our study has identified a minimalist nanovaccine with C1 lipid nanoparticle (LNP) that effectively promotes mRNA delivery and antigen presentation with a self-adjuvant feature through activating TLR4 signaling.
Hongxia Zhang +12 more
semanticscholar +1 more source
Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)
Journal of Experimental Medicine, 1999 Bacterial lipopolysaccharide (LPS) provokes a vigorous, generalized proinflammatory state in the infected host. Genetic regulation of this response has been localized to the Lps locus on mouse chromosome 4, through study of the C3H/HeJ and C57BL/10ScCr ...
S. Qureshi +6 more
semanticscholar +1 more source