Results 31 to 40 of about 347,248 (305)

Decreased Toll-like Receptor (TLR) 2 and 4 Expression in Spermatozoa in Couples with Unexplained Recurrent Spontaneous Abortion (URSA)

Iranian Journal of Allergy, Asthma and Immunology, 2019
Studies have shown that toll-like receptors (TLRs) play some important roles in reproductive processes such as ovulation, spermatogenesis, sperm capacitation, fertilization, and pregnancy to the best of our knowledge, no study has evaluated the ...
Nasrin Sereshki, Alireza Andalib, Ataollah Ghahiri, Ferdos Mehrabian, Roya Sherkat, Abbas Rezaei   +5 more
doaj   +1 more source

Toll-like Receptor 4 and Hepatic Fibrogenesis [PDF]

Seminars in Liver Disease, 2010
Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver.
Jean-Philippe, Pradere, Juliane S, Troeger, Dianne H, Dapito, Ali A, Mencin, Robert F, Schwabe   +4 more
openaire   +2 more sources

Mincle suppresses Toll-like receptor 4 activation [PDF]

Journal of Leukocyte Biology, 2016
Abstract Regulation of Toll-like receptor responses is critical for limiting tissue injury and autoimmunity in both sepsis and sterile inflammation. We found that Mincle, a C-type lectin receptor, regulates proinflammatory Toll-like receptor 4 signaling. Specifically, Mincle ligation diminishes Toll-like receptor 4–mediated inflammation,
Greco, Stephanie H, Mahmood, Syed Kashif, Vahle, Anne-Kristin, Ochi, Atsuo, Batel, Jennifer, Deutsch, Michael, Barilla, Rocky, Seifert, Lena, Pachter, H Leon, Daley, Donnele, Torres-Hernandez, Alejandro, Hundeyin, Mautin, Mani, Vishnu R, Miller, George   +13 more
openaire   +3 more sources

Toll-like Receptor 4 Polymorphisms and Atherogenesis

New England Journal of Medicine, 2002
The ability to mount a prominent inflammatory response to bacterial pathogens confers an advantage in innate immune defense but may signal an increased risk of atherosclerosis. We determined whether recently discovered genetic variants of toll-like receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial ...
Cooke, G, Segal, S, Hill, A
openaire   +4 more sources

Toll‐like receptor 4 in CNS pathologies [PDF]

Journal of Neurochemistry, 2010
J. Neurochem. (2010) 114, 13–27.AbstractThe responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage‐like cells of the nervous system. An important contributor to microglial activation is toll‐like
Buchanan, M., Hutchinson, M., Watkins, L., Yin, H.   +3 more
openaire   +3 more sources

EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA

Медицинская иммунология, 2017
Currently actively  discussed  the  role  of innate immunity receptors, in particular TLRs  in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya, L. S. Namazova-Baranova, M. V. Khoreva, B. G. Bragvadze, A. D. Ogurtsova, A. A. Alekseeva, V. А. Gankovskii, O. А. Svitich   +7 more
doaj   +1 more source

Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation

Indian Journal of Gastroenterology, 2021
Gastrointestinal inflammation is a hallmark of highly prevalent disorders, including cancer treatment–induced mucositis and ulcerative colitis. These disorders cause debilitating symptoms, have a significant impact on quality of life, and are poorly ...
Janine S. Y. Tam, J. Coller, P. Hughes, C. Prestidge, J. Bowen   +4 more
semanticscholar   +1 more source

Ulvan Activates Chicken Heterophils and Monocytes Through Toll-Like Receptor 2 and Toll-Like Receptor 4

Frontiers in Immunology, 2018
Responsiveness to invasive pathogens, clearance via the inflammatory response, and activation of appropriate acquired responses are all coordinated by innate host defenses.
Nathalie Guriec, Frédérick Bussy, Christelle Gouin, Olivier Mathiaud, Benoit Quero, Matthieu Le Goff, Pi Nyvall Collén   +6 more
doaj   +1 more source

Effect of Toll‐like receptor 4 on depressive‐like behaviors induced by chronic social defeat stress

Brain and Behavior, 2020
Introduction A growing body of evidence suggests that stress is an important factor in depression, and pro‐inflammatory cytokines contribute to the occurrence and development of depression in both animal models and human patients.
Ke Zhang, Wenjuan Lin, Juntao Zhang, Yawei Zhao, Xiaqing Wang, Mei Zhao   +5 more
doaj   +1 more source

Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids

Nutrients, 2018
Obesity leads to an inflammatory condition that is directly involved in the etiology of cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer.
M. Rogero, P. Calder
semanticscholar   +1 more source