Results 41 to 50 of about 347,248 (305)
Frontiers in Immunology, 2020 Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the innate immune response.
Peng Zhang +5 more
semanticscholar +1 more source
Toll-like receptor 2 and Toll-like receptor 4 predict favorable prognosis in local pancreatic cancer
Tumor Biology, 2018 Toll-like receptors play an essential role in our innate immune system and are a focus of interest in contemporary cancer research. Thus far, Toll-like receptors have shown promising prognostic value in carcinomas of the oral cavity, colon, and ovaries ...
Mira A Lanki +6 more
doaj +1 more source
Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholine but Not by Alpha Ketoglutarate. [PDF]
PLoS ONE, 2015 Toll-like receptor 4 and proinflammatory cytokines play a central role in the progression of nonalcoholic fatty liver disease. We investigated IL-1, IL-6 and TNFα production and toll-like receptor 4 in both--obese and lean patients with non-alcoholic ...
Agnieszka Zwolak +4 more
doaj +1 more source
Computational Approaches to Toll-Like Receptor 4 Modulation [PDF]
Molecules, 2016 Toll-like receptor 4 (TLR4), along with its accessory protein myeloid differentiation factor 2 (MD-2), builds a heterodimeric complex that specifically recognizes lipopolysaccharides (LPS), which are present on the cell wall of Gram-negative bacteria, activating the innate immune response.
Jean-Marc Billod +3 more
openaire +4 more sources
Targeting Toll‐like receptor‐4 to tackle preterm birth and fetal inflammatory injury
Clinical & Translational Immunology, 2020 Every year, 15 million pregnancies end prematurely, resulting in more than 1 million infant deaths and long‐term health consequences for many children.
Sarah A Robertson +7 more
doaj +1 more source
Toll-like receptor 4 limits transmission of Bordetella bronchiseptica. [PDF]
PLoS ONE, 2014 Transmission of pathogens has been notoriously difficult to study under laboratory conditions leaving knowledge gaps regarding how bacterial factors and host immune components affect the spread of infections between hosts.
Olivier Rolin +5 more
doaj +1 more source
Journal of Experimental Medicine, 2002 Allergic asthma is an inflammatory lung disease initiated and directed by T helper cells type 2 (Th2). The mechanism involved in generation of Th2 responses to inert inhaled antigens, however, is unknown.
S. Eisenbarth +5 more
semanticscholar +1 more source
Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure.
Journal of Hepatology, 2020 BACKGROUND AND AIMS Toll-like receptor 4 (TLR4) plays an essential role in mediating organ injury in acute liver failure (ALF) and acute-on-chronic liver failure (ACLF).
C. Engelmann +16 more
semanticscholar +1 more source
Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
Frontiers in Cell and Developmental Biology, 2022 Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets.
Philip Mzyk +4 more
doaj +1 more source
Journal of Neuroinflammation, 2019 Baicalin, which is isolated from Radix Scutellariae, possesses strong biological activities including an anti-inflammation property. Recent studies have shown that the anti-inflammatory effect of baicalin is linked to toll-like receptor 4 (TLR4), which ...
Liting Guo +9 more
semanticscholar +1 more source