Results 101 to 110 of about 196,754 (276)

Autoinmunidad y receptores tipo Toll = Autoimmunity and toll-like receptors

Iatreia, 2012
La respuesta inmune innata está conformada por un conjunto de mecanismos que permiten reconocer los componentes propios del organismo y diferenciarlos de los microorganismos invasores para generar una primera línea de defensa.
Ossa Giraldo, Ana Claudia, Úsuga Perilla, Xiomara   +1 more
doaj  

The implication of dendritic cells in lung diseases: Immunological role of toll-like receptor 4

Genes and Diseases
The immune responses play a profound role in the progression of lung lesions in both infectious and non-infectious diseases. Dendritic cells, as the “frontline” immune cells responsible for antigen presentation, set up a bridge between innate and ...
Shurui Xuan, Yuan Ma, Honglei Zhou, Shengwei Gu, Xin Yao, Xiaoning Zeng   +5 more
doaj   +1 more source

Toll‐like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma [PDF]

, 2012
Diogenes S. Ferreira, Raquel Annoni, Luiz Fernando Ferraz da Silva, Monique Buttignol, A. B. G. Santos, Maria C. R. Medeiros, Luciana Nogueira de Sousa Andrade, Ching Yong Yick, Peter Sterk, Jorge Luiz Mello Sampaio, Marisa Dolhnikoff, Sally E. Wenzel, Thaís Mauad   +12 more
openalex   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

The role of Toll-like receptor 4 gene polymorphism in the development of organ dysfunction in patients with severe pneumonia associated with A/H1N1 influenza

, 2023
A.V. Malyarchikov, К. Г. Шаповалов   +1 more
openalex   +2 more sources

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling [PDF]

, 2019
Samuel J. Tong, Adam A. Wall, Yu Hung, Lin Luo, Jennifer L. Stow   +4 more
openalex   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Expression of Toll-Like Receptor 2 on Human Schwann Cells: a Mechanism of Nerve Damage in Leprosy

, 2003
Rosane B. de Oliveira, María Teresa Ochoa, Peter A. Sieling, Thomas H. Rea, Anura Rambukkana, Euzenir Nunes Sarno, Robert L. Modlin   +6 more
openalex   +1 more source