Results 151 to 160 of about 608,641 (362)

Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9

Nature Communications, 2017
DNA degradation products are frequently found in the endosome, but how they regulate the activation of Toll-like receptors is not known. Here the authors show that single-stranded DNA as short as two nucleotides can enhance the ability of longer DNA ...
Jelka Pohar, Duško Lainšček, Karolina Ivičak-Kocjan, Miša-Mojca Cajnko, Roman Jerala, Mojca Benčina   +5 more
doaj   +1 more source

Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis

Advanced Science, EarlyView.
Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao, Ruiyan Ma, Shuai Hao, Xuxin Tan, Xue Zeng, Rui Song, Bing Chen, Zhezhe Cao, Wei Shen, Zhenchun Luo, Jianfeng Huang, He Huang, Liangming Liu, Chenyang Duan   +13 more
wiley   +1 more source

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells [PDF]

, 2000
Marta Muzio, Daniela Bosisio, Nadia Polentarutti, Giovanna D’Amico, Antonella Stoppacciaro, Roberta Mancinelli, Cornelis van’t Veer, Giselle Pentón‐Rol, Luigi Ruco, Paola Allavena, Alberto Mantovani   +10 more
openalex   +1 more source

Reprogramming of Fatty Acid Metabolism via PPARα‐Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis

Advanced Science, EarlyView.
This study identifies fatty acid desaturase 2 (FADS2) as a key regulator linking polyunsaturated fatty acid (PUFA) metabolism to psoriatic inflammation. FADS2 deficiency impairs docosahexaenoic acid (DHA) biosynthesis, enhances NF‐κB signaling, and promotes neutrophil‐driven skin inflammation. PPARα transcriptionally activates FADS2, and its activation
Jiangluyi Cai, Xue Zhou, Yu Zhuang, Lian Cui, Rui Ma, Youdong Chen, Nan Yang, Qianyu Chen, Yuanyuan Wang, Peiyao Zhu, Lingling Yao, Qian Yu, Xiaomin She, Xuyang Zhou, Yuemeng Huang, Zengyang Yu, Xilin Zhang, Jiajing Lu, Yuling Shi, Chunyuan Guo   +19 more
wiley   +1 more source

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide [PDF]

, 2000
Egil Lien, Terry K. Means, Holger Heine, Atsutoshi Yoshimura, Shoichi Kusumoto, Koichi Fukase, Matthew J. Fenton, Masato Oikawa, Nilofer Qureshi, Brian G. Monks, Robert W. Finberg, Robin R. Ingalls, Douglas T. Golenbock   +12 more
openalex   +1 more source

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Nature Immunology, 2010
T. Kawai, S. Akira
semanticscholar   +1 more source

Creating a new Ontology: a Modular Approach [PDF]

, 2010
Creating a new Ontology: a Modular ApproachComment: in Adrian Paschke, Albert Burger, Andrea Splendiani, M. Scott Marshall, Paolo Romano: Proceedings of the 3rd International Workshop on Semantic Web Applications and Tools for the Life Sciences ...
Dmitrieva, Julia, Verbeek, Fons J.
core   +2 more sources

The CXCL10‐CXCR3 Axis Induces Tumor‐Associated Neutrophils to Interfere with CTLs‐Mediated Antitumor Activity in EBV‐Associated Epithelial Cancers

Advanced Science, EarlyView.
Compared with EBV‐negative epithelial cancer cells, EBV‐associated epithelial cancer cells exhibit enhanced secretion of chemokines, including CXCL10 and CCL5, to attract neutrophils. Via the CXCL10‐CXCR3 axis‐mediated positive feedback loop, neutrophils within EBV‐associated epithelial cancer cells are induced to form abundant NETs, which facilitate ...
Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song, Jingjing Zhao, Hao Chen, Si Li, Lifeng Zhang, Chi Xu, Yan Ren, Yong Tao, Qijing Wang, Jia He, Yongqiang Li, Sisi Xie, Yuanyuan Liu, Yan Wang, Xinyi Yang, Jinqi You, Songzuo Xie, Yingzi Li, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia   +24 more
wiley   +1 more source

The Lipopolysaccharide-activated Toll-like Receptor (TLR)-4 Induces Synthesis of the Closely Related Receptor TLR-2 in Adipocytes [PDF]

, 2000
Ying Lin, Hyangkyu Lee, Anders H. Berg, Michael P. Lisanti, Lawrence Shapiro, Philipp E. Scherer   +5 more
openalex   +1 more source