Results 151 to 160 of about 618,091 (376)
The implication of dendritic cells in lung diseases: Immunological role of toll-like receptor 4
Genes and DiseasesThe immune responses play a profound role in the progression of lung lesions in both infectious and non-infectious diseases. Dendritic cells, as the “frontline” immune cells responsible for antigen presentation, set up a bridge between innate and ...
Shurui Xuan +5 more
doaj +1 more source
Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
Nature Communications, 2017 DNA degradation products are frequently found in the endosome, but how they regulate the activation of Toll-like receptors is not known. Here the authors show that single-stranded DNA as short as two nucleotides can enhance the ability of longer DNA ...
Jelka Pohar +5 more
doaj +1 more source
Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes [PDF]
, 2018 Mengju Liu +9 more
openalex +1 more source
Advanced Science, EarlyView.Although Zinc(II) complexes are effective in photodynamic therapy, their efficacy is limited by the poor tissue penetration of light. This work introduces a novel zinc(II) complex for sonodynamic therapy. Under ultrasound activation, it generates substantial singlet oxygen, induces pyroptosis in breast cancer cells, and promotes anti‐tumor immune ...
Sijie Wen +8 more
wiley +1 more source
Microvascular Health as a Key Determinant of Organismal Aging
Advanced Science, EarlyView.This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini +4 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a nanoparticle‐embedded nanofiber (5F/STFM/R‐ES) to inhibit melanoma growth and reduce the risk of metastasis and recurrence. The drug delivery system induces ferroptosis and potentiates immunotherapy through resiquimod (R848) and Fe/Mn‐based metal‐polyphenol networks (TFM).
Mingyang Li +10 more
wiley +1 more source
Triggering of Toll-like receptors in the elderly. A pilot study relevant for vaccination [PDF]
, 2017 The impaired ability of the elderly to mount an efficient immune response after exposure to microbes or vaccines represents a major challenge in protection against pathogens in ageing.
Candore Giuseppina +5 more
core
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Nature Immunology, 2010 T. Kawai, S. Akira
semanticscholar +1 more source
B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns
Advanced Science, EarlyView.B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang +16 more
wiley +1 more source