Results 201 to 210 of about 618,091 (376)
Advanced Science, EarlyView.Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei +10 more
wiley +1 more source
Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy
Advanced Science, EarlyView.This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li +5 more
wiley +1 more source
Association of toll-like receptors polymorphisms with COPD risk in Chinese population [PDF]
, 2022 Shulei Sun, Yuehao Shen, Jing Feng
openalex +1 more source
Advanced Science, EarlyView.T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang +13 more
wiley +1 more source
Macrophage migration inhibitory factor enhances lipopolysaccharide-induced fibroblast proliferation by inducing toll-like receptor 4 [PDF]
, 2016 Zheng-de Xi, Changyi Xie, Yebin Xi
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Advanced Science, EarlyView.Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye +12 more
wiley +1 more source
Modulation of Toll-like Receptors with Natural Compounds: A Therapeutic Avenue Against Inflammaging? [PDF]
Int J Mol SciAndrei C +3 more
europepmc +1 more source
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide [PDF]
Bing Li +5 more
openalex +1 more source