Results 211 to 220 of about 310,367 (307)

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source

Hepatocyte Toll-like receptors contribute to the hepcidin inflammatory response to pathogens and pathogen-derived ligands. [PDF]

Hemasphere
Bonitz K, Colucci S, Qiu R, Altamura S, Sparla R, Mudder K, Zimmermann S, Hentze MW, Muckenthaler MU, Marques O.   +9 more
europepmc   +1 more source

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite [PDF]

, 2001
Marco Antônio Campos, Igor C. Almeida, Osamu Takeuchi, Shizuo Akira, Eneida P. Valente, Daniela O. Procópio, Luiz R. Travassos, Jason A. Smith, Douglas T. Golenbock, Ricardo T. Gazzinelli   +9 more
openalex   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Genome-wide identification and characterisation of Toll-like receptors in Chinese spiny frog (<i>Quasipaa spinosa</i>). [PDF]

Front Genet
Li Z, Gao Z, Mo D, Zhu Z, Zhang J, Liu M, Xiao H, Zhou M, Gao T, Liang R.   +9 more
europepmc   +1 more source

Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor andBorrelia burgdorferiOuter Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling [PDF]

, 2001
Yonca Bulut, Emmanuelle Faure, Lisa Thomas, Ozlem Equils, Moshe Arditi   +4 more
openalex   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source

Unveiling the molecular interactions between bisphenol A and the cell surface Toll-like receptors: Implications for immune health. [PDF]

Toxicol Rep
Rajak P, Ganguly A.
europepmc   +1 more source

Activated human hepatic stellate cells express CD14 and toll like receptors 2 and 4 (TLR-2, TLR-4)

, 2000
Claus Hellerbrand, WE Thasler, Cornelia M. Gelbmann, Stijn Lambrecht, Katrin Letschert, G. Lock, J. Schoelmerich   +6 more
openalex   +1 more source

Toll-Like Receptor 4 Mediates Intracellular Signaling Without TNF-α Release in Response to Cryptococcus neoformans Polysaccharide Capsule [PDF]

, 2001
Shmuel Shoham, Chao Huang, Jianmin Chen, Douglas T. Golenbock, Stuart M. Levitz   +4 more
openalex   +1 more source