Results 231 to 240 of about 618,091 (376)

Toll Like Receptors in the Larynx: Implications for Laryngeal Immunology. [PDF]

Laryngoscope
Gowda M, Venkatraman A, Mechler-Hickson A, Lungova V, Thibeault SL.   +4 more
europepmc   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context. [PDF]

Front Immunol
Li H, Li X, Zhu Y, Xu J, Zhao Q, Chen X, Zhang Y, Zhao L, Chen Y, Weng R, Chen K.   +10 more
europepmc   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons

, 2015
Martin Helley, Wondwossen Abate, Simon K. Jackson, J. H. Bennett, Steve Thompson   +4 more
openalex   +2 more sources

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Toll-like Receptors in Immuno-Metabolic Regulation of Emotion and Memory. [PDF]

Cells
Crespo-Quiles C, Femenía T.
europepmc   +1 more source

Impact of Toll-Like Receptor 2 and 9 Gene Polymorphisms on COVID-19: Susceptibility, Severity, and Thrombosis

, 2023
Alshaymaa M. Alhabibi, Asmaa S. Hassan, Nashwa Mohamed Abd Elbaky, Hoda A. Eid, Mohie Aldeen Abd Alzaher Khalifa, Maisa A. Abdel Wahab, Azza Ali Althoqapy, Aml E. Abdou, Doaa Mohammed Zakaria, Eman Mostafa Nassef, Sammar Ahmed Kasim, Ola I. Saleh, Asmaa Abdelghany Elsheikh, Mahmoud Lotfy, Alaa H. Sayed   +14 more
openalex   +2 more sources

In Situ Assembly of Transformable Monopeptide on Activated Neutrophils Attenuates NETs‐Induced Hepatocellular Carcinoma Metastasis by Disrupting NE Nuclear Translocation

Advanced Science, EarlyView.
Activated neutrophils release extracellular traps (NETs) that promote tumor metastasis. FTP‐NPs are develpoed, a peptidic nanomaterial that binds NE on neutrophil membranes, forming NE‐fibril clusters that deactivate NE and prevent NETs formation. This strategy reduces metastasis and enhances the anti‐tumor immune response by targeting NE subcellular ...
Yichi Chen, Yijun Wang, Haitao Shang, Jiayue Qiu, Ruotian Zhang, Yuxiang Xiong, Tong Wang, Fengyi Wang, Anbang Wu, Xin Lin, Bolin Wu, Chen Huang, Wen Cheng, Lu Zhang   +13 more
wiley   +1 more source

Increased expression of Toll-like receptors and associated alarmins in temporal arteries of patients with giant cell arteritis. [PDF]

Mol Med
Seidlberger S, Schirmer M, Wietzorrek G, Jiménez-Heffernan JA, Pardines M, de Las Fuentes Monreal M, González-Gay MA, Castañeda S, Santos-Sierra S.   +8 more
europepmc   +1 more source