Results 231 to 240 of about 196,754 (276)

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Making teaching an attractive profession: What are the challenges and opportunities for minority ethnic teachers in England?

British Educational Research Journal, EarlyView.
Abstract This paper explores the challenges and opportunities surrounding the recruitment and retention of minority ethnic teachers in England. Drawing on interview data from 33 teachers and school leaders of diverse ethnic backgrounds, it investigates whether racialised barriers identified in earlier research have shifted in the current context of ...
Antonina Tereshchenko, Feyisa Demie, Stephen Gorard, Yiyang Gao, Beng Huat See, Nadia Siddiqui   +5 more
wiley   +1 more source

Evidence against the role of toll-like receptors 7 and 8 in sex selection in mice, cattle, and humans. [PDF]

iScience
Zhao R, Liu J, Bakhtari A, Shen J, Fayad-Costa A, Wang B, Tian X.   +6 more
europepmc   +1 more source

Mindfulness and resilience: The experiences of global majority students in a mindfulness intervention Programme at a UK university

British Educational Research Journal, EarlyView.
Abstract Wellbeing in higher education (HE) in the United Kingdom has been increasingly prioritised for many institutions, with a growing demand for student support requests. There are various determinants in life that can influence mental health. As such, protected characteristics, including race, can indicate that students who are Black or Asian ...
Amy Bywater, Helen Keane
wiley   +1 more source

Unveiling the molecular interactions between bisphenol A and the cell surface Toll-like receptors: Implications for immune health. [PDF]

Toxicol Rep
Rajak P, Ganguly A.
europepmc   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

Altered Expression of Toll-Like Receptors and Key Signaling Genes in Sertoli Cells of Azoospermic Patients. [PDF]

J Reprod Infertil
Lakpour MR, Aflatoonian R, Sadighi Gilani MA, Hajihosseini R, Sabbaghian M.   +4 more
europepmc   +1 more source

PROSPECTS OF TOLL-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS

, 2019
Alexandra Alexandrovna Nikonova, Musa Rahimovich Khaitov, Rahim Musaevich Khaitov   +2 more
openalex   +1 more source

Calcium retinoate nanoparticle mediated microglial polarization to regulate inflammatory microenvironment for therapy of neuroinflammatory disease

BMEMat, EarlyView.
A nano‐drug based on retinoic acid and calcium is developed, which can be rapily endocytosed by microglia and decomposed into small molecule/ion storms in lysosomes. This nano‐drug regulates microglial phenotype switching from M1 to M2 while indirectly guiding neuronal differentiation of endogenous neural stem cells, thereby ameliorating ...
Shuo Zhang, Yuan Yao, Wenfeng Shao, Jiapei Shi, Benjie Wei, Chunhui Sun, Jingang Wang, Jiaming Shi, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Na Ren, Yuchun Tang, Wenjuan Zhou, Shuping Wang   +13 more
wiley   +1 more source

Inflammatory Modulation of Toll-like Receptors in Periodontal Ligament Stem Cells: Implications for Periodontal Therapy. [PDF]

Cells
Mekhemar M, Terheyden I, Dörfer C, Fawzy El-Sayed K.   +3 more
europepmc   +1 more source