Results 31 to 40 of about 300,180 (287)

Involvement of Toll-Like Receptor 4 in Decreased Vasopressor Response Following Trauma/Hemorrhagic Shock

Critical Care Explorations, 2021
OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD, Fernando Dos Santos, PhD, Joyce B. Li, MSc, Federico Aletti, PhD, Geert Schmid-Schonbein, PhD, Erik B. Kistler, MD, PhD   +5 more
doaj   +1 more source

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +2 more sources

The Role of Toll Like Receptors in Pregnancy [PDF]

International Journal of Fertility and Sterility, 2013
For many years, the innate immunity was of less interest than the adaptive immunity because it was perceived to have secondary importance in the functionality of the immune system.
Elham Amirchaghmaghi, Seyed Abdolvahab Taghavi, Farnaz Shapouri, Shaghayegh Saeidi, Abbas Rezaei, Reza Aflatoonian   +5 more
doaj  

Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis

Respiratory Research, 2005
Background Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin.
Uddman Rolf, Jansson Lennart, Erjefält Jonas, Adner Mikael, Fransson Mattias, Cardell Lars-Olaf   +5 more
doaj   +1 more source

A central role for Toll-like 4 receptors in interstitial cystitis? [PDF]

, 2018
[Extract] Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a clinical enigma. Estimated to affect over 8 million women globally, it is a challenge to diagnose and to treat effectively, due to an unknown etiology and complex, poorly understood
Chess-Williams, Russ, McDermott, Catherine, Sellers, Donna Jayne   +2 more
core   +1 more source

Identification of single nucleotide polymorphisms in Toll-like receptor candidate genes associated with tuberculosis infection in water buffalo (Bubalus bubalis) [PDF]

, 2014
Toll-like receptors play a key role in innate immunity by recognizing pathogens and activating appropriate responses. Pathogens express several signal molecules (pathogen-associated molecular patterns, PAMPs) essential for survival and pathogenicity ...
Acutis, Pier Luigi, Alfano, Flora, BARONE, AMALIA, Borriello, Giorgia, Desiato, Rosanna, Galiero, Giorgio, Lucibelli, Maria Gabriella, Maniaci, Maria Grazia, Pasquali, Paolo, Peletto, Simone, Tarantino, Michela, Urciuolo, Giovanna   +11 more
core   +1 more source

Toll-like receptors of deuterostome invertebrates

Frontiers in Immunology, 2012
Defensive systems against pathogens are responsible not only for survival or lifetime of an individual but also for the evolution of a species. Innate immunity is expected to be more important for invertebrates than mammals, given that adaptive immunity ...
Honoo eSatake, Toshio eSekiguchi
doaj   +1 more source

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
core   +2 more sources

Toll-like receptors in lupus nephritis

Journal of Biomedical Science, 2018
The pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is based on the loss of self-tolerance against ubiquitous autoantigens involving all mechanisms of adaptive immunity.
Satish Kumar Devarapu, Hans-Joachim Anders   +1 more
doaj   +1 more source

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources