Results 11 to 20 of about 5,209,524 (289)

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light [PDF]

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +2 more sources

Toll‐like receptors in mammalian sperm [PDF]

Reproductive Medicine and Biology
Background Toll‐like receptors (TLRs) are critical components of the innate immune system and are expressed in various cells, including the reproductive system. Although their roles in female reproductive tissues such as the ovaries and uterus, including
Takashi Umehara, Takahiro Yamanaka, Masayuki Shimada   +2 more
doaj   +2 more sources

Toll-Like Receptors, Their Ligands, and Atherosclerosis

The Scientific World Journal, 2011
Atherosclerosis is a disease characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins.
Conrad P. Hodgkinson, Shu Ye
doaj   +8 more sources

Toll-like receptors: versatile players in tumor [PDF]

Frontiers in Immunology
Toll-like receptors (TLRs) are a class of pattern-recognition receptors first identified for their role in detecting microbial pathogens and initiating innate immune responses.
Yang Yang, Yang Yang, Ruyu Pi
doaj   +2 more sources

Toll‐like receptors in health and disease [PDF]

MedComm
Toll‐like receptors (TLRs) are inflammatory triggers and belong to a family of pattern recognition receptors (PRRs) that are central to the regulation of host protective adaptive immune responses. Activation of TLRs in innate immune myeloid cells directs
Kunyu Wang, Hanyao Huang, Qi Zhan, Haoran Ding, Yi Li   +4 more
doaj   +2 more sources

Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infection. [PDF]

, 2010
Toll-like receptors (TLRs) are a potent trigger for inflammatory immune responses. Without tight regulation their activation could lead to pathology, so it is imperative to extend our understanding of the regulatory mechanisms that govern TLR expression ...
Martin Vordermeier, Allen, RL, Rachel L. Allen, Pilsbury, LE, Louise E. Pilsbury, Vordermeier, M   +5 more
core   +1 more source

Toll like receptors agonists-based nanomedicines as veterinary immunotherapies

Precision Nanomedicine, 2020
Many infections affecting animals enter across mucosa, needing of secretory immunity to reject the disease; protection against some pathogens must be early, fast, and specifically elicited, while from others must be wide enough to fight against ...
Federico L Parra, María J Morilla, Eder L Romero   +2 more
doaj   +1 more source

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source

Toll-like Receptors in Viral Encephalitis

Viruses, 2021
Viral encephalitis is a rare but serious syndrome. In addition to DNA-encoded herpes viruses, such as herpes simplex virus and varicella zoster virus, RNA-encoded viruses from the families of Flaviviridae, Rhabdoviridae and Paramyxoviridae are important ...
Olivia Luise Gern, Felix Mulenge, Andreas Pavlou, Luca Ghita, Imke Steffen, Martin Stangel, Ulrich Kalinke   +6 more
doaj   +1 more source

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi, Forrest, A, Schroder, K, Forrest, Alistair, Kawai, J, Kawaji, H, Wells, Christine A, Faulkner, G, Carninci, P, Hume, DA, Carninci, Piero, Grimmond, SM, Himes, SR, Lo, Sandra, Hume, David, Schroder, Kate, Taylor, D, Grimmond, Sean M, Faulkner, Geoffrey, Chalk, Alistair, Kasukawa, T, Himes, S Roy, Grimmond, Sean, Kawai, Jun, Waddell, Nic, Lo, Yu-Lan Sandra, Hayashizaki, Yoshihide, Kasukawa, Takeya, Wells, Christine, Katayama, S, Hayashizaki, Y, Chalk, Alistair M, Katayama, Shintaro, Hume, David A, Chalk, AM, Taylor, Darrin, Kawaji, Hideya, Wells, CA, Waddell, N, Lo, S, Kai, C   +40 more
core   +1 more source