Results 21 to 30 of about 4,939 (213)
Critical Care Explorations, 2021 OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD +5 more
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Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis
Respiratory Research, 2005 Background Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin.
Uddman Rolf +5 more
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Toll-like receptors of deuterostome invertebrates
Frontiers in Immunology, 2012 Defensive systems against pathogens are responsible not only for survival or lifetime of an individual but also for the evolution of a species. Innate immunity is expected to be more important for invertebrates than mammals, given that adaptive immunity ...
Honoo eSatake, Toshio eSekiguchi
doaj +1 more source
Toll-like receptors in lupus nephritis
Journal of Biomedical Science, 2018 The pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is based on the loss of self-tolerance against ubiquitous autoantigens involving all mechanisms of adaptive immunity.
Satish Kumar Devarapu +1 more
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Toll-like Receptors and Thrombopoiesis
International Journal of Molecular Sciences, 2023 Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispensable role in inflammatory diseases. However, thrombocytopenia is a common hematologic problem in the clinic, and it
Xiaoqin Tang +11 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Toll-like receptors and atherosclerosis [PDF]
Medicinski Glasnik, 2009 Toll like receptors (TLR) are receptors with major role in activationof immune system by regulating production of chemokinesand cytokines, which makes them important in different types ofinflammatory reactions- bacterial, viral, parasitic, acute ...
Jerko Barbić +4 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Toll‐like receptors in mammalian sperm
Reproductive Medicine and BiologyBackground Toll‐like receptors (TLRs) are critical components of the innate immune system and are expressed in various cells, including the reproductive system. Although their roles in female reproductive tissues such as the ovaries and uterus, including
Takashi Umehara +2 more
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Toll-Like Receptors and Myocardial Inflammation
International Journal of Inflammation, 2011 Toll-like receptors (TLRs) are a member of the innate immune system. TLRs detect invading pathogens through the pathogen-associated molecular patterns (PAMPs) recognition and play an essential role in the host defense.
Yan Feng, Wei Chao
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