Results 61 to 70 of about 7,136,272 (253)

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Electrically Stimulated and Frequency-Tunable Photonic Tonic Spiking Neuron Based on a DFB-LD Under Optical Feedback

Photonics
Based on a distributed feedback laser diode (DFB-LD) under optical feedback, a novel scheme for generating neuron-like tonic spiking is proposed, and the characteristics of the generated neuron-like tonic spiking are numerically investigated.
Zhiqiang Lei, Chaotao He, Qiupin Wang, Pu Ou, Zhengmao Wu, Guangqiong Xia   +5 more
doaj   +1 more source

GABAA Receptor-Mediated Tonic Inhibition in Thalamic Neurons [PDF]

, 2005
Tonic GABAA receptor-mediated inhibition is typically generated by subunit-containing extrasynaptic receptors. Because the subunit is highly expressed in the thalamus, we tested whether thalamocortical (TC) neurons of the dorsal lateral geniculate ...
Cope, David W., Crunelli, Vincenzo, Hughes, Stuart W.   +2 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

tDCS cranial nerve Co-stimulation: Unveiling brainstem pathways involved in trigeminal nerve direct current stimulation in rats

Brain Stimulation
Background: The effects of transcranial direct current stimulation (tDCS) are generally thought to result from the polarization of cortical neurons by the weak electric fields it creates.
Alireza Majdi, Liyi Chen, Lars E. Larsen, Robrecht Raedt, Myles Mc Laughlin   +4 more
doaj   +1 more source

Isometric exercise facilitates attention to salient events in women via the noradrenergic system

NeuroImage, 2020
The locus coeruleus (LC) regulates attention via the release of norepinephrine (NE), with levels of tonic LC activity constraining the intensity of phasic LC responses.
Mara Mather, Ringo Huang, David Clewett, Shawn E. Nielsen, Ricardo Velasco, Kristie Tu, Sophia Han, Briana L. Kennedy   +7 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5′-Triphosphate in the Rat

Journal of Pharmacological Sciences, 2011
We investigated actions of uridine 5′-triphosphate (UTP) in rat aorta, cerebral and mesenteric arteries, and their single myocytes. UTP (≥10 μM) elicited an inward-rectifying current strongly reminiscent of activation of P2X1 receptor, and a similar ...
Megumi Sugihara, Hiromitsu Morita, Miho Matsuda, Hisanori Umebayashi, Shunichi Kajioka, Shinichi Ito, Motohiro Nishida, Ryosuke Inoue, Toshiko Futatsuki, Jun Yamazaki, Yasuo Mori, Ryuji Inoue, Yushi Ito, Kihachiro Abe, Masato Hirata   +14 more
doaj   +1 more source

Changes in Activity of the Same Thalamic Neurons to Repeated Nociception in Behaving Mice. [PDF]

PLoS ONE, 2015
The sensory thalamus has been reported to play a key role in central pain sensory modulation and processing, but its response to repeated nociception at thalamic level is not well known.
Yeowool Huh, Jeiwon Cho
doaj   +1 more source

Modulating anxiety with extrasynaptic inhibition [PDF]

, 2014
Traumatic experiences and stress can lead to complex behavioral adaptations, including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes are, however, poorly understood.
Botta, Paolo
core   +1 more source