Results 41 to 50 of about 7,136,272 (253)

Na+/K+-ATPase inhibition partially mimics the ethanol-induced increase of the Golgi cell-dependent component of the tonic GABAergic current in rat cerebellar granule cells.

PLoS ONE, 2013
Cerebellar granule cells (CGNs) are one of many neurons that express phasic and tonic GABAergic conductances. Although it is well established that Golgi cells (GoCs) mediate phasic GABAergic currents in CGNs, their role in mediating tonic currents in ...
Marvin R Diaz, Aya Wadleigh, Shyam Kumar, Erik De Schutter, C Fernando Valenzuela   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Primate Cerebellar Granule Cells Exhibit a Tonic GABAAR Conductance that is not Affected by Alcohol: A Possible Cellular Substrate of the Low Level of Response Phenotype.

Frontiers in Neural Circuits, 2013
In many rodent brain regions, alcohol increases vesicular release of GABA, resulting in an increase in the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) and the magnitude of tonic GABAA receptor (GABAAR) currents.
Claudia eMohr, Olena eKolotushkina, Joshua S Kaplan, John eWelsh, James eDaunais, Kathleen eGrant, Kathleen eGrant, David James Rossi   +7 more
doaj   +1 more source

Cell type-specific properties of subicular GABAergic currents shape hippocampal output firing mode. [PDF]

PLoS ONE, 2012
GABAergic function of the subiculum is central to the regulation of hippocampal output activity. Subicular neuronal networks are indeed under potent control by local inhibition. However, information about the properties of GABAergic currents generated by
Gabriella Panuccio, Stefano Vicini, Massimo Avoli   +2 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus

Frontiers in Neural Circuits, 2015
Experimental and computational studies demonstrate that different sets of intrinsic and synaptic conductances can give rise to equivalent activity patterns.
Wulf-Dieter C. Krenz, Anna R. Parkers, Edmund W. Rodgers, Deborah J. Baro   +3 more
doaj   +1 more source

A Plan Tonic növénykondicionáló szer hatásának vizsgálata őszi búza, napraforgó, szója és cukorrépa kultúrákban

, 2022
Mivel a világ népességszámának drasztikus növekedésének eredményeként egyre nagyobb problémát jelent az emberek élelmiszerrel történő ellátása, a hatékony mezőgazdasági termelésre a korábbiaknál is nagyobb szükség van. Előtérbe kerülnek azok a módszerek,
Kujbus, Balázs
core  

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals

Neurobiology of Disease, 2010
Neurosteroid sensitivity of GABAA receptor mediated inhibition of the hippocampal dentate granule cells (DGCs) is reduced in animal models of temporal lobe epilepsy.
Karthik Rajasekaran, Suchitra Joshi, Chengsan Sun, Zakaria Mtchedlishvilli, Jaideep Kapur   +4 more
doaj   +1 more source