Results 21 to 30 of about 7,136,272 (253)

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]

, 2014
Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole, Mitchell, Elizabeth A., Swinny, Jerome, Elizabeth A Mitchell, Lambert, Jeremy J., Jerome D Swinny, Scott J Greig, Edward P Maguire, Maguire, Edward P., Jeremy J Lambert, Nicole Corteen, Swinny, Jerome D., Delia Belelli, Greig, Scott J., David J K Balfour, Balfour, David J. K., Belelli, Delia   +16 more
core   +1 more source

Bestrophin1 channels are insensitive to ethanol and do not mediate tonic GABAergic currents in cerebellar granule cells

Frontiers in Neuroscience, 2012
The granule cell layer of the cerebellum functions in spatio-temporal encoding of information. Granule cells are tonically inhibited by spillover of GABA released from Golgi cells and this tonic inhibition is facilitated by acute ethanol. Recently it was
Marvin R Diaz, Aya eWadleigh, Benjamin A Hughes, John J Woodward, Carlos Fernando Valenzuela   +4 more
doaj   +1 more source

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity. [PDF]

, 2015
GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA ...
Rusakov, Dmitri A., Walker, MC, Savtchenko, L, Pavlov, I, Megalogeni, M, Walker, Matthew C., Rusakov, DA, Savtchenko, Leonid, Pavlov, Ivan, Megalogeni, Maria   +9 more
core   +1 more source

Metabotropic Regulation of Extrasynaptic GABAA Receptors

Frontiers in Neural Circuits, 2013
A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under ...
William Martin Connelly, Adam C Errington, Giuseppe eDi Giovanni, Vincenzo eCrunelli   +3 more
doaj   +1 more source

OTMM Tonic Test Dataset v3.0.0

, 2023
This repository contains datasets of annotated tonic frequencies of the audio recordings of Ottoman-Turkish makam music. The annotations are compiled from several research papers published under the CompMusic project.
CompMusic, Hasan Sercan, Atlı, Şentürk, Sertan   +2 more
core   +1 more source

Exploring neuronal bistability at the depolarization block. [PDF]

PLoS ONE, 2012
Many neurons display bistability--coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in
Andrey Dovzhenok, Alexey S Kuznetsov
doaj   +1 more source

Cocaine-Induced Changes in Tonic Dopamine Concentrations Measured Using Multiple-Cyclic Square Wave Voltammetry in vivo

Frontiers in Pharmacology, 2021
For over 40 years, in vivo microdialysis techniques have been at the forefront in measuring the effects of illicit substances on brain tonic extracellular levels of dopamine that underlie many aspects of drug addiction. However, the size of microdialysis
Jason Yuen, Jason Yuen, Abhinav Goyal, Abhinav Goyal, Aaron E. Rusheen, Aaron E. Rusheen, Abbas Z. Kouzani, Michael Berk, Jee Hyun Kim, Susannah J. Tye, Charles D. Blaha, Kevin E. Bennet, Kevin E. Bennet, Dong-Pyo Jang, Kendall H. Lee, Kendall H. Lee, Hojin Shin, Yoonbae Oh, Yoonbae Oh   +18 more
doaj   +1 more source

Long-Term Effects of Moderate Concussive Brain Injury During Adolescence on Synaptic and Tonic GABA Currents in Dentate Granule Cells and Semilunar Granule Cells

Frontiers in Neuroscience, 2022
Progressive physiological changes in the hippocampal dentate gyrus circuits following traumatic brain injury (TBI) contribute to temporal evolution of neurological sequelae.
Akshay Gupta, Akshay Gupta, Laura Dovek, Archana Proddutur, Archana Proddutur, Fatima S. Elgammal, Vijayalakshmi Santhakumar, Vijayalakshmi Santhakumar   +7 more
doaj   +1 more source

Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring. [PDF]

Ann Clin Transl Neurol
The early‐morning surge in false seizure alarms supports exploring time‐ or state‐dependent detection thresholds to reduce false detections. ABSTRACT Seizure detection devices can improve the safety of children with epilepsy, yet high false alarms limit their clinical applicability.
Shahbakhti M, Bosch AT, van der Palen J, Leijten FS, van Dijk JP, Lazeron RHC, Thijs RD.   +6 more
europepmc   +2 more sources

Successful application of burst spinal cord stimulation for refractory upper limb pain: a case series

Journal of International Medical Research, 2021
Spinal cord stimulation (SCS) has been used to treat sustained pain that is intractable despite various types of treatment. However, conventional tonic waveform SCS has not shown promising outcomes for spinal cord injury (SCI) or postamputation pain. The
Kuen Su Lee, Yoo Kyung Jang, Gene Hyun Park, In Jae Jun, Jae Chul Koh   +4 more
doaj   +1 more source