Results 11 to 20 of about 7,136,272 (253)
GABAA receptor β3 subunit expression regulates tonic current in developing striatopallidal medium spiny neurons [PDF]
Frontiers in Cellular Neuroscience, 2011 The striatum is a key structure for movement control, but the mechanisms that dictate the output of distinct subpopulations of medium spiny projection neurons (MSNs), striatonigral projecting and dopamine D1 receptor- (D1+) or striatopallidal projecting ...
Megan eJanssen +3 more
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PLoS ONE, 2011 GABAergic inhibition in the central nervous system (CNS) can occur via rapid, transient postsynaptic currents and via a tonic increase in membrane conductance, mediated by synaptic and extrasynaptic GABA(A) receptors (GABA(A)Rs) respectively.
Stefanie M Jones, Mary J Palmer
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Methods for recording and measuring tonic GABA¬A receptor-mediated inhibition [PDF]
Frontiers in Neural Circuits, 2013 Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but ...
Damian eBright, Trevor G. Smart
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Second-Derivative-Based Background Drift Removal for Tonic Dopamine Measurement in Fast-Scan Cyclic Voltammetry [PDF]
, 2022 The dysregulation of dopamine, a neuromodulator, is associated with a broad spectrum of brain disorders, including Parkinson’s disease, addiction, and schizophrenia.
Yunho, Jeong +4 more
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Tonic GABAa current in absence epilepsy [PDF]
Typical absence seizures are characteristic of many idiopathic generalised epilepsies and the only seizure-type in childhood absence epilepsy. We know that absence seizures arise in thalamocortical networks and that GABAergic agents exacerbate or induce ...
Fyson, Sarah Jane
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GABA-Independent GABAA Receptor Openings Maintain Tonic Currents [PDF]
, 2013 Activation of GABAA receptors (GABAARs) produces two forms of inhibition: ‘phasic’ inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic GABA release, and tonic inhibition generated by the persistent activation of ...
Herd, Murray B +27 more
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Extrasynaptic δ-subunit containing GABAA receptors [PDF]
Journal of Integrative Neuroscience, 2021 γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
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Astrocytic actions on extrasynaptic neuronal currents
Frontiers in Cellular Neuroscience, 2015 In the last few decades, knowledge about astrocytic functions has significantly increased. It was demonstrated that astrocytes are not passive elements of the central nervous system, but active partners of neurons.
Balazs ePal
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The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibition [PDF]
, 2014 Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Herd, Murray B. +5 more
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Frontiers in Cellular Neuroscience, 2014 γ-Aminobutyric acid (GABA) depolarizes embryonic cerebrocortical neurons and continuous activation of the GABAA receptor (GABAAR) contributes to their tonic depolarization.
Tomonori eFurukawa +5 more
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