Results 171 to 180 of about 61,437 (248)

Unveiling the Anticancer Potential: Computational Exploration of Nitrogenated Derivatives of (+)-Pancratistatin as Topoisomerase I Inhibitors. [PDF]

Int J Mol Sci
Mohamed MA, Elsaman T, Elderdery AY, Alsrhani A, Ghanem HB, Alruwaili MM, Hamza SMA, Mekki SEI, Alotaibi HA, Mills J.   +9 more
europepmc   +1 more source

Antibiotic Resistance, Biofilm Genes, and smeDEF Efflux Pump in Clinical Stenotrophomonas maltophilia Isolates From Iran

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Iranian clinical Stenotrophomonas maltophilia isolates showed high susceptibility to trimethoprim/sulfamethoxazole, minocycline, and levofloxacin, but marked resistance to ceftazidime and ticarcillin‐clavulanate, alongside widespread biofilm production and resistance genes.
Haneen Fadhil Jasim, Nisreen Salah Majeed, Asmaa A. Salam, Rania Hameed Hamad, Yeganeh Behrouzi, Erta Rajabi, Razieh Shahbazi   +6 more
wiley   +1 more source

Pursuing Polypharmacology: Benzothiopyranoindoles as G-Quadruplex Stabilizers and Topoisomerase I Inhibitors for Effective Anticancer Strategies. [PDF]

ACS Med Chem Lett
Salerno S, Barresi E, Roggia M, Natale B, Marzano S, Hyeraci M, Reina SCR, Baglini E, Amato J, Salvati E, Dalla Via L, Da Settimo F, Cosconati S, Taliani S.   +13 more
europepmc   +1 more source

Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application

MedComm, Volume 7, Issue 2, February 2026.
Hydrogels offer an innovative platform for cancer immunotherapy. Through tailorable crosslinking strategies, they form customizable drug delivery platforms that address diverse therapeutic requirements by loading specific immunotherapeutic agents. These systems demonstrate significant clinical potential for precise tumor immunotherapy.
Xiaohua Chen, Shan Wu, Yueyang Zhang, Lilu Feng, Yang Chen, Xuzhao Yang, Ke Men, Jiuqun Zhu, Ming Li   +8 more
wiley   +1 more source

Determining Preclinical Safety of Aclarubicin in Pediatric Malignancies

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background Anthracyclines are among the most effective chemotherapeutic agents used to treat pediatric malignancies. However, their clinical use is limited by dose‐dependent toxicities, particularly cardiotoxicity and secondary malignancies.
Darleen S. Tu, Aaron K. Olson, Kimberly S. Waggie, Nicolas M. Garcia, Virginia J. Hoglund, Stephanie I. Walter, Jenna R. Rosinski, Harini Sadeeshkumar, Radhika Patel, Erolcan Sayar, Michael C. Haffner, Lisa Maves, Jacques Neefjes, Jay F. Sarthy, Elizabeth R. Lawlor, Shireen S. Ganapathi   +15 more
wiley   +1 more source

New Benzimidazole-Triazole Derivatives as Topoisomerase I Inhibitors: Design, Synthesis, Anticancer Screening, and Molecular Modeling Studies. [PDF]

ACS Omega
Çevik UA, Kaya B, Celik I, Rudrapal M, Rakshit G, Karayel A, Levent S, Osmaniye D, Sağlık Özkan BN, Baysal M, Atlı Ekliog Lu Ö, Özkay Y, Kaplancıklı ZA.   +12 more
europepmc   +1 more source

Machine Learning Models Combined with Virtual Screening and Molecular Docking to Predict Human Topoisomerase I Inhibitors. [PDF]

Molecules, 2019
Li B, Kang X, Zhao D, Zou Y, Huang X, Wang J, Zhang C.   +6 more
europepmc   +1 more source

Effect of Testosterone Therapy on Cytochrome P450 3A and P‐Glycoprotein Activities Using Midazolam and Digoxin as Probe Substrates Among Transgender Adults

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT Background Gender‐affirming testosterone therapy is one part of the standard of care for more than 1 million transgender adults in the United States. Testosterone therapy may influence the activities of drug‐metabolizing enzymes and transporters, but knowledge about its effect on the pharmacokinetics of other medications is limited.
Michiko Hunter, Rene Coig, Linda Risler, Kristen K. Patton, Radhika R. Narla, Dina N. Greene, Alson K. Burke, Elizabeth Micks, Mary F. Hebert, Lauren R. Cirrincione   +9 more
wiley   +1 more source

Developing a Phosphospecific IHC Assay as a Predictive Biomarker for Topoisomerase I Inhibitors. [PDF]

J Histochem Cytochem, 2018
Ando K, Tohme YH, Srinivasiah A, Taylor-Parker J, Harrington Y, Shah AK, Oki E, Brahmandam M, Bharti AK.   +8 more
europepmc   +1 more source

Fluoroquinolone‐Associated Psychiatric and Ocular Adverse Events: A Disproportionality Analysis Using Real‐World Data From FAERS (2011–2024)

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
This pharmacovigilance study identifies a wide range of rapid‐onset neuropsychiatric and ocular adverse effects linked to fluoroquinolones (FQ). Disproportionality analysis revealed a disproportionate reporting of suicidal ideation and visual impairment following FQ treatment, emphasizing the urgent need for cautious prescribing and strengthened safety
Hau‐Tak Chau, Ngan Pan Bennett Au
wiley   +1 more source