Results 191 to 200 of about 5,441 (220)
Advanced Science, EarlyView.SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio +6 more
wiley +1 more source
Magnetotransport Signatures of Spin–Orbit Coupling in High‐Temperature Cuprate Superconductors
Advanced Science, EarlyView.Large angle‐dependent magnetoresistance and planar Hall effects emerge at the superconducting transition of YBa2Cu3O7−x$\mathrm{YBa_2Cu_3O_{7-x}}$ thin films. These anomalous transport signatures, absent in the normal state, point to spin‐polarized quasiparticle dynamics enabled by an unexpected spin–orbit coupling landscape in cuprate superconductors,
Aleix Barrera +6 more
wiley +1 more source
Polarization Dynamics in Ferroelectrics: Insights Enabled by Machine Learning Molecular Dynamics
Advanced Science, EarlyView.Machine learning molecular dynamics is presented as a route to capture polarization switching, domain wall kinetics, topological polar textures, and polar mechanical coupling beyond the limits of conventional atomistic methods. This Perspective surveys recent progress and identifies key methodological directions, including long‐range electrostatics ...
Dongyu Bai +3 more
wiley +1 more source
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Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains
Trends in Genetics, 2023Topologically associating domains (TADs) are integral to spatial genome organization, instructing gene expression, and cell fate. Recently, several advances have uncovered roles for noncoding RNAs (ncRNAs) in the regulation of the form and function of mammalian TADs.
Vinay Tergaonkar, Melissa Fullwood
exaly +4 more sources
Chromatin-Driven Behavior of Topologically Associating Domains
Journal of Molecular Biology, 2015 Metazoan genomes are highly organized inside the cell nucleus. Topologically associating domains (TADs) represent the building blocks of genome organization, but their linear modularity does not explain alone their spatial organization. Indeed, the chromatin type adorning a TAD can shape its structure and drives its nuclear positioning and its function.
Filippo Ciabrelli, Giacomo Cavalli
exaly +4 more sources
Methods for the Analysis of Topologically Associating Domains (TADs)
2021Chromatin folding in the 3D space of the nucleus can be explored through high-throughput chromosome conformation capture (Hi-C) approaches. These experiments quantify the number of interactions between any pair of genomic loci in the genome and, thus, allow building genome-scale maps of intra- and inter-chromosomal contacts (contact maps).
Marie, Zufferey +2 more
openaire +2 more sources
Topologically associating domains are stable units of replication-timing regulation [PDF]
Nature, 2014 Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell-type-specific with at least half the genome switching replication timing during development, primarily in units of 400-800 kilobases ('replication domains'), whose positions are preserved in different cell types ...
, David Gilbert, Vishnu Dileep
exaly +3 more sources
Form and function of topologically associating genomic domains in budding yeast [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance In metazoans, topological domains are regions in the genome that more frequently associate with themselves than with neighboring regions. These domains are important for regulating transcription and replication. However, topological domains were thought to be absent in budding yeast.
Aaron F Straight +2 more
exaly +3 more sources
Measuring the three-dimensional structural properties of topologically associating domains
2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2018Genome topologically associating domains (TADs) are mega base pair (Mbp) sized genomic regions that may be the structural and functional units of the genome. To better understand their structural properties and the relationship between structural properties and genetic and epigenetic features, we designed and benchmarked two measures to capture the ...
Tong Liu 0028, Zheng Wang 0049
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Gene regulation during development in the light of topologically associating domains
WIREs Developmental Biology, 2015During embryonic development, complex transcriptional programs govern the precision of gene expression. Many key developmental genes are regulated via cis‐regulatory elements that are located far away in the linear genome. How sequences located hundreds of kilobases away from a promoter can influence its activity has been the subject of numerous ...
Silvia Remeseiro +2 more
openaire +2 more sources