Results 211 to 220 of about 1,201,498 (234)

Solvent‐Free Synthesis of Ultrabright Carbon Dots With Near‐Unity Quantum Yield for High‐Performance Light‐Emitting Diodes

Advanced Science, EarlyView.
A rational, solvent‐free synthesis utilizing 2,6‐diaminonaphthalene produces ultrabright green‐emissive carbon dots. Regulated by a self‐limiting oxidative capping mechanism, excitons undergo ultrafast intra‐particle funneling from the nitrogen‐doped carbon core to emissive surface traps.
Hyeonjin Park, Su Hwan Lee, Sejeong Seo, Soye Park, Soo min Ji, Hyunda Jo, Sehyeon Park, Young‐Hoon Kim, Woosung Kwon   +8 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Emerging Regulatory Mechanisms of Noncoding RNAs in Topologically Associating Domains

Trends in Genetics, 2023
Topologically associating domains (TADs) are integral to spatial genome organization, instructing gene expression, and cell fate. Recently, several advances have uncovered roles for noncoding RNAs (ncRNAs) in the regulation of the form and function of ...
Vinay Tergaonkar, Melissa J Fullwood
exaly   +5 more sources

Chromatin-Driven Behavior of Topologically Associating Domains

Journal of Molecular Biology, 2015
Metazoan genomes are highly organized inside the cell nucleus. Topologically associating domains (TADs) represent the building blocks of genome organization, but their linear modularity does not explain alone their spatial organization. Indeed, the chromatin type adorning a TAD can shape its structure and drives its nuclear positioning and its function.
Filippo Ciabrelli, Giacomo Cavalli
exaly   +4 more sources

Topologically Associating Domains Are Stable Units of Replication-Timing Regulation [PDF]

Nature, 2014
Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell-type-specific with at least half the genome switching replication timing during development, primarily in units of 400-800 kilobases ('replication domains'), whose positions are preserved in different cell types ...
James Taylor, David M Gilbert, Vishnu Dileep   +2 more
exaly   +3 more sources

Structure, Function and Evolution of Topologically Associating Domains (TADs) atHOX Loci [PDF]

FEBS Letters, 2015
Hox genes encode transcription factors necessary for patterning the major developing anterior to posterior embryonic axis. In addition, during vertebrate evolution, various subsets of this gene family were co-opted along with the emergence of novel body ...
Denis Duboule
exaly   +2 more sources

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TADShop: systematic benchmarking and identification of topologically associating domains

Nature Methods
Topologically associating domains (TADs) are structural units of chromatin organization. Their definition and identification rely on computational analyses of chromosome conformation capture data. Here we systematically assessed and compared 43 TAD identification strategies, none of which excelled in all tests, often displaying conflicting results.
Pumin Li, Andras Hatos, Miljan Petrovic, Gian Marco Franceschini, Luca Nanni, Daniele Tavernari, Giovanni Ciriello   +6 more
openaire   +3 more sources

A Review of Methods to Quantify the Genomic Similarity of Topological Associating Domains

Journal of Computational Biology, 2019
Abstract Topologically associating domains (TADs) are the most fundamental elements and significant structures of the eukaryotic genome. Currently, algorithms have been developed to find the TADs. But few algorithms are reported to compare the similarity of TADs between genomes.
Yufang Li, Aoshen Wu, Gang Liu, Lei Liu
openaire   +2 more sources

A functional variant in the boundary of a topological association domain is associated with pancreatic cancer risk

Molecular Carcinogenesis, 2019
AbstractAs the proper binding of CCCTC‐binding factor (CTCF) in the boundaries of topological association domains (TADs) was important for chromatin structures and gene regulation, we hypothesized that single nucleotide polymorphisms (SNPs) affecting CTCF binding in TAD boundaries might contribute to pancreatic cancer (PC) susceptibility.
Shufang Mei, Juntao Ke, Jianbo Tian, Pingting Ying, Nan Yang, Xiaoyang Wang, Danyi Zou, Xiating Peng, Yang Yang, Ying Zhu, Yajie Gong, Rong Zhong, Jiang Chang, Xiaoping Miao   +13 more
openaire   +2 more sources

Automatic Association of Cross-Domain Network Topology

2022 IEEE International Conference on Trust, Security and Privacy in Computing and Communications (TrustCom), 2022
Sai Han, Zelin Wang, Guangquan Wang, Qiukeng Fang, Hongbing Ma, Lin Lin, Lexi Xu, Heng Zhang   +7 more
openaire   +1 more source