Results 41 to 50 of about 5,441 (220)
Topologically associating domain boundaries are required for normal genome function
Communications Biology, 2023 AbstractTopologically associating domain (TAD) boundaries partition the genome into distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere with normal gene expression and cause disease phenotypes1–3, but the overall extent to which this occurs remains unknown.
Sudha Rajderkar +28 more
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Deciphering the species-level structure of topologically associating domains [PDF]
, 2021 Summary Chromosome conformation capture technologies such as Hi-C have revealed a rich hierarchical structure of chromatin, with topologically associating domains (TADs) as a key organizational unit, but experimentally reported TAD architectures, currently determined separately for each cell type, are lacking for many
Rohit Singh, Bonnie Berger
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Order and stochasticity in the folding of individual Drosophila genomes
Nature Communications, 2021 Genomes are partitioned into topologically associating domains (TADs). Here the authors present single-nucleus Hi-C maps in Drosophila at 10 kb resolution, demonstrating the presence of chromatin compartments in individual nuclei, and partitioning of the
Sergey V. Ulianov +17 more
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DeTOKI identifies and characterizes the dynamics of chromatin TAD-like domains in a single cell
Genome Biology, 2021 Topologically associating domains (TAD) are a key structure of the 3D mammalian genomes. However, the prevalence and dynamics of TAD-like domains in single cells remain elusive.
Xiao Li +3 more
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A comparison of topologically associating domain callers over mammals at high resolution
BMC Bioinformatics, 2022 Background Topologically associating domains (TADs) are locally highly-interacting genome regions, which also play a critical role in regulating gene expression in the cell. TADs have been first identified while investigating the 3D genome structure over
Emre Sefer
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eLife, 2018 We have developed a generally adaptable, novel high-throughput Viral Chromosome Conformation Capture assay (V3C-seq) for use in trans that allows genome-wide identification of the direct interactions of a lytic virus genome with distinct regions of the ...
Kinjal Majumder +6 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Genome Biology, 2017 Background The human genome is hierarchically organized into local and long-range structures that help shape cell-type-specific transcription patterns.
Kevin Van Bortle +2 more
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FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Using LDpred2 to adapt polygenic risk score techniques for methylation score creation
BMC Research NotesObjective This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylome-wide ...
Kristoffer Sandås +6 more
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