Results 51 to 60 of about 1,201,498 (234)
Clinical and Translational Medicine, 2022 Background During meiosis of mammalian cells, chromatin undergoes drastic reorganization. However, the dynamics of the three‐dimensional (3D) chromatin structure during the development of female germline stem cells (FGSCs) are poorly understood.
Geng G. Tian +3 more
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Frontiers in Immunology, 2021 Though viruses have their own genomes, many depend on the nuclear environment of their hosts for replication and survival. A substantial body of work has therefore been devoted to understanding how viral and eukaryotic genomes interact.
Kinjal Majumder, Abigail J. Morales
doaj +1 more source
The CTCF Anatomy of Topologically Associating Domains [PDF]
, 2019 Abstract Topologically associated domains (TADs) are defined as regions of self-interaction. To date, it is unclear how to reconcile TAD structure with CTCF site orientation, which is known to coordinate chromatin loops anchored by Cohesin rings at convergent CTCF site pairs.
Nanni, Luca +7 more
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Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. [PDF]
Nat Genet, 2019 Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Zhang Y +21 more
europepmc +2 more sources
Disruption of topologically associating domains by structural variations in tetraploid cottons
Genomics, 2021 Structural variations (SVs) are recognized to have an important role in transcriptional regulation, especially in the light of resolved 3D genome structure using high-throughput chromosome conformation capture (Hi-C) technology in mammals. However, the effect of SVs on 3D genome organization in plants remains rarely understood.
Yuexuan, Long +7 more
openaire +2 more sources
Stem Cell Reports, 2019 Summary: During mammalian embryogenesis, changes in morphology and gene expression are concurrent with epigenomic reprogramming. Using human embryonic stem cells representing the preimplantation blastocyst (naive) and postimplantation epiblast (primed ...
Stephanie L. Battle +10 more
doaj +1 more source
HiTAD: detecting the structural and functional hierarchies of topologically associating domains from chromatin interactions. [PDF]
Nucleic Acids Res, 2017 Wang XT, Cui W, Peng C.
europepmc +2 more sources
, 2021 (A, D) Hi-C data for W12 clone G2 is compared to (B, E) Hi-C data for W12 clone D2 using (C, F) an insulation score interpreting the boundaries of topologically associating domains (TADs) for HPV16 integration sites within W12 clone G2 (Chr5: 50–55 Mbp ...
Emma L. A. Drane (11331464) +11 more
core +1 more source
HiCmapTools: a tool to access HiC contact maps
BMC Bioinformatics, 2022 Background With the development of HiC technology, more and more HiC sequencing data have been produced. Although there are dozens of packages that can turn sequencing data into contact maps, there is no appropriate tool to query contact maps in order to
Jia-Ming Chang +4 more
doaj +1 more source
Topologically associating domain boundaries are required for normal genome function
Communications Biology, 2023 AbstractTopologically associating domain (TAD) boundaries partition the genome into distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere with normal gene expression and cause disease phenotypes1–3, but the overall extent to which this occurs remains unknown.
Sudha Rajderkar +28 more
openaire +6 more sources