Results 31 to 40 of about 1,957 (165)

Heritability of metoprolol and torsemide pharmacokinetics

Clinical Pharmacology & Therapeutics, 2015
Genetic variation in the pharmacokinetics of metoprolol and torsemide due to polymorphisms in CYP2D6, CYP2C9, and OATP1B1 has been extensively studied. However, it is still unknown how much of the variation in pharmacokinetics of these two clinically important drugs in total is due to genetic factors.
Matthaei, Johannes, Brockmöller, Jürgen, Tzvetkov, Mladen, Sehrt, Daniel, Sachse-Seeboth, Cordula, Hjelmborg, Jacob v. B., Möller, Sören, Halekoh, Ulrich, Hofmann, Ute, Schwab, Matthias, Kerb, Reinhold   +10 more
openaire   +3 more sources

Photosensitive Lichenoid Reaction to Torsemide-a Loop Diuretic [PDF]

Mayo Clinic Proceedings, 1997
Torsemide, a potent loop diuretic of the sulfonylurea class, has been available for clinical use in the United States since 1993. Adverse generalized and cutaneous reactions to this medication are uncommon and are usually mild and transient. In this article, we describe an 82-year-old man who had a photosensitive lichenoid reaction due to torsemide ...
D R, Byrd, I, Ahmed
openaire   +2 more sources

HPLC – Quality by Design Approach for Simultaneous Detection of Torsemide, Spironolactone and Their Degradant Impurities

Pharmaceutical Technology in Hospital Pharmacy, 2018
A simple, highly robust (quality by design (QbD) approach), precise and accurate method using high performance liquid chromatography coupled to mass spectrometry has been established for the simultaneous separation, identification and quantitation of a ...
Bihola Unnati, Prajapati Prajesh, Agrawal Y. K.   +2 more
doaj   +1 more source

Management of COVID-19 Related Myocarditis: A Systematic Review

Asian Journal of Medical Sciences, 2021
On January 7 in China, one patient was identified with a new corona virus in throat culture, and World Health Organization called it severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Şahbender Koç, Yusuf Şener , Emre Doğan , Emine Kırdağ , Emine Altuntaş , Ömer Bedir , Efe Edem   +6 more
doaj   +1 more source

Exploring Risks of Adverse Drug Events From Single Drug to Three‐Drug Combination

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Use of three‐drug combinations is common and could increase the risk of adverse drug events (ADEs). Signals of ADEs from three‐drug combinations could be identified from real‐world data, and the risks of ADEs from single drug exposure to three‐drug combination exposure could be illustrated by a graphic model.
Yi Shi, Anna Sun, Chien‐Wei Chiang, Yuedi Yang, Katherine M. Hunold, Jing Xu, Mu Shan, Allison Lu, Massimiliano Russo, Jeffrey M. Caterino, Michael T. Eadon, Lang Li, Jing Su, Macarius Donneyong, Pengyue Zhang   +14 more
wiley   +1 more source

Renin-Angiotensin-Aldosterone System Activation and Diuretic Response in Ambulatory Patients With Heart FailurePlain-Language Summary

Kidney Medicine, 2022
Rationale & Objective: Heart failure treatment relies on loop diuretics to induce natriuresis and decongestion, but the therapy is often limited by diuretic resistance.
Jonathan G. Amatruda, Rebecca Scherzer, Veena S. Rao, Juan B. Ivey-Miranda, Michael G. Shlipak, Michelle M. Estrella, Jeffrey M. Testani   +6 more
doaj   +1 more source

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2203-2211, July 2026.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres, Justyna Wozniak, Hannah Fölsch, Anja Knueppel‐Ruppert, Verena Graeff, Andrea Kriegisch‐Stumpf, Harald Dormann, Julia C. Stingl, Katja S. Just   +8 more
wiley   +1 more source

Diuretic Intensity Score and Mortality in Hospitalized Heart Failure Patients: A Multicenter Propensity‐Matched Analysis

Clinical Cardiology, Volume 49, Issue 6, June 2026.
In two independent cohorts of 17 826 hospitalized heart failure patients (MIMIC‐IV and a Chinese database), a higher Diuretic Intensity Score was associated with lower 28‐ and 90‐day all‐cause mortality. These findings are hypothesis‐generating and warrant validation in prospective randomized trials.
Jianwei Zhou
wiley   +1 more source

Development and evaluation of a chronotherapeutic drug delivery system of torsemide

Brazilian Journal of Pharmaceutical Sciences, 2011
The objective of this study was to prepare and evaluate chronotherapeutic drug delivery systems (ChrDDs) of torsemide. Compression coated tablets (CCT) containing torsemide in the core tablet were prepared by the compression coating technique with ...
Songa Ambedkar Sunil, Nali Sreenivasa Rao, Meka Venkata Srikanth, Michael Uwumagbe Uhumwangho, Kommana Srinivas Phani Kumar, Kolaplli Venkata Ramana Murthy   +5 more
doaj   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source