Results 51 to 60 of about 2,244 (195)

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

CYP2C9 polymorphisms and the interindividual variability in pharmacokinetics and pharmacodynamics of the loop diuretic drug torsemide

, 2004
Introduction: According to in vitro data, torsemide (INN, torasemide) is a substrate of the genetically polymorphic enzyme cytochrome P450 (CYP) 2C9, but the impact of CYP2C9 polymorphisms on torsemide pharmacokinetics and pharmacodynamics has not been ...
Zirk, A., Tuchen, F., Vormfelde, Stefan Viktor, Engelhardt, S., Kirchheiner, Julia, Meineke, Ingolf, Brockmoeller, Juergen   +6 more
core   +1 more source

Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 267-273, May 2026.
ABSTRACT The pharmacokinetics of sildenafil are ill‐defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client‐owned dogs with
Mariko Yata, Teresa C. DeFrancesco, John D. Bonagura, Mark G. Papich   +3 more
wiley   +1 more source

Precision Under Pressure: Scalp Block and Dexmedetomidine for Brain Abscess Drainage in a Patient With Complex Cyanotic Heart Disease

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Cyanotic heart disease is a known risk factor for brain abscess. Anesthesia for burr‐hole drainage in these patients can be challenging due to complications like an increase in right‐to‐left shunt, arrhythmias, heart failure, and paradoxical air embolism. The risk of these complications can be decreased by choosing a scalp block with conscious
Sandeep Khatri, Ashish Raj Tiwari, Barsha Karki, Manisha Poudel, Anish Sah   +4 more
wiley   +1 more source

Genetic variation at the CYP2C locus and its association with torsemide biotransformation

, 2007
In 97 unselected volunteers and two additional homozygous carriers of CYP2C9(*)3, we investigated the oral clearance of torsemide in relation to 37 polymorphisms at the CYP2C gene locus.
Nuernberg, P., Kirchheiner, Julia, Kirchheiner, J., Brockmoeller, Juergen, Toliat, Mohammad Reza, Brockmoeller, J., Schirmer, Markus Anton, Vormfelde, Stefan Viktor, Meineke, Ingolf, Vormfelde, S.V., Schirmer, M., Toliat, M.R., Meineke, I.   +12 more
core   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Altered sensorium in a patient with chronic kidney disease: Unmasking the unusual

Journal of Current Research in Scientific Medicine
Wernicke encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency, classically associated with chronic alcohol abuse. However, it is increasingly recognized in nonalcoholic settings.
Saif Quaiser, Ruhi Khan
doaj   +1 more source

Real‐World Effectiveness of Tolvaptan for Hyponatremia in Cirrhosis Across Global Regions: A Target Trial Emulation

JGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Background Tolvaptan promotes electrolyte‐free water excretion and is widely used in Asia for ascites, but in Western countries its use is limited to hyponatremia because of hepatotoxicity concerns. Methods We performed a retrospective cohort study using the TriNetX Research Network, emulating a target trial of cirrhotic patients with ...
Kazuya Okushin, Ryosuke Tateishi, Mitsuhiro Fujishiro, Takeya Tsutsumi, Kazuhiko Koike, Tomohiro Tanaka   +5 more
wiley   +1 more source

How do we define high and low dose intensity of heart failure medications: a scoping review

BMC Cardiovascular Disorders, 2023
Background Older adults with heart failure often experience adverse drug events with high doses of heart failure medications. Recognizing whether a patient is on a high or low dose intensity heart failure medication can be helpful for daily practice ...
Min Ji Kwak, Qian Wang, Chukwuma Onyebeke, Travis Holder, Parag Goyal, Rajender Aparasu, Abhjeet Dhoble, Holly M. Holmes   +7 more
doaj   +1 more source

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source