Results 51 to 60 of about 3,074 (210)

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, EarlyView.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Development and evaluation of a chronotherapeutic drug delivery system of torsemide

Brazilian Journal of Pharmaceutical Sciences, 2011
The objective of this study was to prepare and evaluate chronotherapeutic drug delivery systems (ChrDDs) of torsemide. Compression coated tablets (CCT) containing torsemide in the core tablet were prepared by the compression coating technique with ...
Songa Ambedkar Sunil, Nali Sreenivasa Rao, Meka Venkata Srikanth, Michael Uwumagbe Uhumwangho, Kommana Srinivas Phani Kumar, Kolaplli Venkata Ramana Murthy   +5 more
doaj   +1 more source

Successful Asfotase Alfa Treatment in an Adult Dialysis Patient With Childhood-Onset Hypophosphatasia [PDF]

, 2017
Hypophosphatasia is an inherited disease characterized by reduced alkaline phosphatase activity, extracellular accumulation of inorganic pyrophosphate, and impaired bone mineralization.
Cooper, Mark S., Quinkler, Marcus, Remde, Hanna   +2 more
core   +1 more source

Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The pharmacokinetics of sildenafil are ill‐defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client‐owned dogs with
Mariko Yata, Teresa C. DeFrancesco, John D. Bonagura, Mark G. Papich   +3 more
wiley   +1 more source

Retrospective study of the association between neutering status and changes secondary to degenerative mitral valve disease [PDF]

, 2019
Dissertação de Mestrado Integrado em Medicina VeterináriaMyxomatous mitral valve disease is the most common cardiovascular disease reported in dogs. Although many patients may remain asymptomatic, some of them progress to left-sided congestive heart ...
Silva, Ana Margarida Ribeiro da
core  

SGLT-2 Inhibitors: A Novel Mechanism in Targeting Glycemic Control in Type 2 Diabetes Mellitus [PDF]

, 2016
OBJECTIVE: To review the chemistry, pharmacology, pharmacodynamics, pharmacokinetics, clinical efficacy, tolerability, dosing, drug interactions, and administration of canagliflozin, dapagliflozin, and empagliflozin, and comparing the benefit and risk ...
Ahmed-Sarwar, Nabila, Nathan, Kobi T, Werner, Paul M   +2 more
core   +2 more sources

Guideline-Directed Medical Therapy in the Management of Cardiovascular Disease: A Cross-sectional Questionnaire-based Study amongst Indian Healthcare Professionals [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Guideline-Directed Medical Therapies (GDMT) are evidence-based treatments recommended by clinical practice guidelines for the management of Cardiovascular Diseases (CVDs).
Prafulla Kerkar, Rajeev Garg, Abhishek Shukla, Viveka Kumar, Akshyaya Pradhan, Arindam Pande, Johan Christopher, Febin Francis, Nitin Zalte, Amarnath Sugumaran   +9 more
doaj   +1 more source

Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics. study protocol for a randomized controlled trial [PDF]

, 2015
Background: Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries.
Clara Rosso, Fernández, DE BLASI, Roberto Alberto, George, Dimopoulos, José Garnacho, Montero, José Miguel, Cisneros, Massimo, Antonelli, The MagicBullet study, Group   +6 more
core   +1 more source

Torsemide Analysis Using Derivative Spectrophotometric Methods

International Journal of Research in Pharmaceutical Sciences, 2020
An accurate stability-indicating method has been developed for the analysis of Torsemide (TOR) in bulk and pharmaceutical dosage forms. The methods used the zero-order spectrum (0D) of TOR aqueous solution (measured at 285 nm) and the instrumentally differentiated first (1D) and second (2D) derivative spectra (measured at 311 nm and 282 nm ...
null Noon AA Kamil, null Shaza W Shantier, null Elrasheed A Gadkariem   +2 more
openaire   +1 more source

Torsemide Versus Furosemide in Heart Failure Patients [PDF]

Journal of Cardiovascular Pharmacology, 2015
Furosemide has historically been the primary loop diuretic in heart failure patients despite data suggesting potential advantages with torsemide. We used the Duke Echocardiography Lab Database to investigate patients admitted with heart failure to Duke Hospital from 2000 to 2010 who were discharged on either torsemide or furosemide.
Mentz, Robert J, Buggey, Jonathan, Fiuzat, Mona, Ersbøll, Mads K, Schulte, Phillip J, DeVore, Adam D, Eisenstein, Eric L, Anstrom, Kevin J, OʼConnor, Christopher M, Velazquez, Eric J   +9 more
openaire   +2 more sources