Results 61 to 70 of about 1,957 (165)

Study of drugs used in cerebral edema in patients with stroke at a tertiary care center

National Journal of Physiology, Pharmacy and Pharmacology, 2017
Background: Various medical and surgical measures have been evolved to treat the raised intracranial pressure (ICP). Medical management mainly involves osmotic agents (glycerol and mannitol), diuretics, and corticosteroids to reduce raised ICP. It is not
Praveen Kumar B, Scandashree K, Padmaja Udaykumar   +2 more
doaj   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1350-1365, December 2025.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Early in‐hospital treatment of acute heart failure. Part 2 of the international expert opinion series on AHF management

ESC Heart Failure, Volume 12, Issue 6, Page 3826-3843, December 2025.
This state‐of‐the‐art review outlines a practical, evidence‐based framework for early acute heart failure management to address critical gaps in current guidance and improve early treatment outcomes. Key components include early identification of co‐existing conditions, bedside haemodynamic profiling, a structured diagnostic approach incorporating both
Anika S. Naidu, Andrew P. Ambrosy, Gad Cotter, Edimar A. Bocchi, Javed Butler, Ovidiu Chioncel, Beth Davison, Anastase Dzudie, Yonathan Freund, Marat Fudim, Sivadasanpillai Harikrishnan, Ivna G. Cunha, Alexandre Mebazaa, Robert J. Mentz, Òscar Miró, Siti E. Nauli, Mateo Pagnesi, Naoki Sato, Gianluigi Savarese, Karen Sliwa‐Hahnle, Yuhui Zhang, Jingmin Zhou, Jan Biegus   +22 more
wiley   +1 more source

Association between PCSK9 inhibitors and acute kidney injury: a pharmacovigilance study

Frontiers in Pharmacology
BackgroundPCSK9 inhibitors are a novel class of lipid-lowering medications, and numerous clinical studies have confirmed their significant role in improving the progression of chronic kidney disease.
Hailing Liu
doaj   +1 more source

Clinical evaluation of a novel fixed-dose combination tablet (Sentorpil® ForteGold) versus compounded powdered medications in dogs with myxomatous mitral valve disease: a randomized, double-blind study

Frontiers in Veterinary Science
IntroductionMyxomatous mitral valve disease (MMVD) is a prevalent cardiac condition in older, small-breed dogs, often managed with multiple medications.
Jiyoung Park, Jiyoon Lee, Sang-Joon Lee, Changbaig Hyun   +3 more
doaj   +1 more source

Rationale and protocol of the LAQUA-HF trial: a factorial randomised controlled trial evaluating the effects of neurohormonal and diuretic agents on health-status reported outcomes in heart failure patients

BMJ Open
Introduction The current guidelines strongly recommend early initiation of multiple classes of cardioprotective drugs for patients with heart failure with reduced ejection fraction to improve prognosis and health status.
Yohei Numasawa, Ikuko Ueda, Shun Kohsaka, Yasuyuki Shiraishi, Takashi Kohno, Toshikazu Tanaka, Nobuhiro Ikemura, Makoto Takei, Mitsuyoshi Urashima, Shintaro Nakano, Yuji Nagatomo, Takenori Ikoma, Tomohiko Ono, Munehisa Sakamoto, Kei Nishikawa, Daihiko Hakuno, Ryo Nakamaru   +16 more
doaj   +1 more source

Lost to Follow‐Up in Pragmatic Trials With Remote Follow‐Up: Insights From CONNECT‐HF and TRANSFORM‐HF

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pragmatic trials commonly use remote follow‐up to reduce participant burden and costs. However, these approaches may increase the risk of lost to follow‐up (LTFU).
Satoshi Shoji, Lisa A. Kaltenbach, Haolin Xu, Robert J. Mentz, Bradi B. Granger, Gregg C. Fonarow, Javed Butler, Joseph B. Lerman, Manasi Tannu, Veraprapas Kittipibul, Min Soo Cho, Eric J. Velazquez, Stephen J. Greene, Kevin J. Anstrom, Amanda Harrington, Christopher B. Granger, Adrian F. Hernandez, Adam D. DeVore   +17 more
doaj   +1 more source

Preparation And Characterisation Of Torsemide Microcapsules

, 2018
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long term medical condition in which the blood pressure in the arteries is persistently elevated. Microencapsulation is a process of applying relatively thin coatings to small particles of solids or droplets of liquids and dispersions. It provides the means of converting liquids to
openaire   +1 more source

Dynamic changes and clinical significance of the gut microbiota and serum metabolites in breast cancer onset, progression and chemotherapy intervention

Frontiers in Oncology
ObjectiveAlterations of the gut microbiota and host metabolic reprogramming are closely associated with the development of breast cancer and the treatment response; however, integrated studies of the gut microbiota and metabolome spanning the transition ...
Shuyun Jiang, Zhanwei Du, Yufei Wang, Hongwei Ma, Zhijun Ma, Xiaowang Wang   +5 more
doaj   +1 more source

Determination of the levels of brain natriuretic peptide and its N-terminal fragment for the evaluation of the efficiency of renal replacement therapy modalities in patients with decompensated chronic heart failure

Терапевтический архив, 2010
Aim: to compare the capabilities of identifying different types of brain natriuretic peptide (BNP) for the evaluation of renal replacement therapy modalities in patients with decompensated chronic heart failure (CHF). Subjects and methods.
E A Tabakyan, A Yu Zaruba, A N Rogoza, D M Ataullakhanova, V V Kukharchuk   +4 more
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