Results 61 to 70 of about 2,397 (210)

Torsemide versus furosemide in patients with heart failure: a systematic review and updated meta-analysis of randomised controlled trials [PDF]

, 2023
Larissa Teixeira, Nathane Santanna Felix, D D P Navalha, Thiago Madeira, C F Farias, Mariana Clemente, Isabela Fernandes Scabello, Rafael Oliva Morgado Ferreira, Allêh Nogueira, Lucas Tramujas   +9 more
openalex   +1 more source

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source

Predictors of a Gabapentinoid–Loop‐Diuretic Prescribing Cascade in U.S. Nursing Home Residents

Journal of the American Geriatrics Society, Volume 74, Issue 2, Page 336-344, February 2026.
Among 23,544 older adult long‐stay nursing home residents who initiated a gabapentinoid in the nursing home (2016–2022), 4.2% experienced a loop diuretic prescribing cascade within 90 days. Predictors of the prescribing cascade included older age, higher medication burden (≥ 15 medications), current receipt of non‐loop diuretics, and titration of ...
Kaleen N. Hayes, Emmanuelle Belanger, Arman Oganisian, Richa Joshi, Xiao (Joyce) Wang, Lexie R. Grove, Kelsey L. Corcoran, Andrew R. Zullo   +7 more
wiley   +1 more source

How do we define high and low dose intensity of heart failure medications: a scoping review

BMC Cardiovascular Disorders, 2023
Background Older adults with heart failure often experience adverse drug events with high doses of heart failure medications. Recognizing whether a patient is on a high or low dose intensity heart failure medication can be helpful for daily practice ...
Min Ji Kwak, Qian Wang, Chukwuma Onyebeke, Travis Holder, Parag Goyal, Rajender Aparasu, Abhjeet Dhoble, Holly M. Holmes   +7 more
doaj   +1 more source

Quantification of torsemide in rabbit plasma by liquid chromatography/electrospray mass spectrometry and its application [PDF]

, 2012
A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of torsemide in rabbit plasma using one-step protein precipitation was developed and validated.
Chen, Chan, Hu, Lufeng, Chen, Xiaole, Wang, Zhibin, Wang, Zhiyi, Wang, Jinjin   +5 more
core  

ESTIMATING THE COMPARATIVE EFFECT OF LOOP DIURETICS USING TRADITIONAL PHARMACOEPIDEMIOLOGICAL AND PRECISION MEDICINE STATISTICAL LEARNING METHODS

, 2022
Loop diuretics (e.g. furosemide, bumetanide, torsemide) are an important therapeutic option for reducing edema, particularly in patients with heart failure (HF). Some studies have examined the safety and effectiveness of furosemide compared to torsemide,
Virkud, Arti
core   +1 more source

Sex differences in blood pressure hemodynamics and white matter hyperintensity volume across racial ethnic groups—HABS‐HD

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION It remains unclear whether specific blood pressure components—systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), or mean arterial pressure (MAP)—are similarly associated with white matter hyperintensity (WMH) burden across sexes within racial and ethnic groups.
Cellas A. Hayes, Anthony Q. Briggs, Joshua L. Gills, The Health and Aging Brain Study (HABS‐HD) Study Team   +3 more
wiley   +1 more source

Genetic variation at the CYP2C locus and its association with torsemide biotransformation

, 2007
In 97 unselected volunteers and two additional homozygous carriers of CYP2C9(*)3, we investigated the oral clearance of torsemide in relation to 37 polymorphisms at the CYP2C gene locus.
Nuernberg, P., Kirchheiner, Julia, Kirchheiner, J., Brockmoeller, Juergen, Toliat, Mohammad Reza, Brockmoeller, J., Schirmer, Markus Anton, Vormfelde, Stefan Viktor, Meineke, Ingolf, Vormfelde, S.V., Schirmer, M., Toliat, M.R., Meineke, I.   +12 more
core   +1 more source

De Novo ACTN2 Variant in a Chinese Neonate With Left Ventricular Non‐Compaction and Metabolic Disturbances: A Rare Case Report

Annals of Noninvasive Electrocardiology, Volume 31, Issue 1, January 2026.
This study reports a 2‐day‐old neonate whose echocardiographic features are consistent with LVNC. The patient exhibited severe metabolic abnormalities and experienced recurrent heart failure episodes temporally associated with these metabolic derangements.
Jinqiu Huang, Ziyue Zhang, Juxian Yang
wiley   +1 more source

VALIDATED STABILITY-INDICATING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE ESTIMATION OF TORSEMIDE

, 2020
Objective: This assessment depicts the strength of exhibiting reverse-phase high performance liquid chromatography (RP-HPLC) method for the estimation of torsemide in pharmaceutical estimation structures.
DEVANNA N, KV, LALITHA, RAVEENDRA REDDY J   +2 more
core