Results 41 to 50 of about 2,199 (188)

ESTIMATING THE COMPARATIVE EFFECT OF LOOP DIURETICS USING TRADITIONAL PHARMACOEPIDEMIOLOGICAL AND PRECISION MEDICINE STATISTICAL LEARNING METHODS [PDF]

, 2022
Loop diuretics (e.g. furosemide, bumetanide, torsemide) are an important therapeutic option for reducing edema, particularly in patients with heart failure (HF). Some studies have examined the safety and effectiveness of furosemide compared to torsemide,
Virkud, Arti
core   +1 more source

Management of COVID-19 Related Myocarditis: A Systematic Review

Asian Journal of Medical Sciences, 2021
On January 7 in China, one patient was identified with a new corona virus in throat culture, and World Health Organization called it severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Şahbender Koç, Yusuf Şener , Emre Doğan , Emine Kırdağ , Emine Altuntaş , Ömer Bedir , Efe Edem   +6 more
doaj   +1 more source

CYP2C9 polymorphisms and the interindividual variability in pharmacokinetics and pharmacodynamics of the loop diuretic drug torsemide

, 2004
Introduction: According to in vitro data, torsemide (INN, torasemide) is a substrate of the genetically polymorphic enzyme cytochrome P450 (CYP) 2C9, but the impact of CYP2C9 polymorphisms on torsemide pharmacokinetics and pharmacodynamics has not been ...
Zirk, A., Tuchen, F., Vormfelde, Stefan Viktor, Engelhardt, S., Kirchheiner, Julia, Meineke, Ingolf, Brockmoeller, Juergen   +6 more
core   +1 more source

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2203-2211, July 2026.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres, Justyna Wozniak, Hannah Fölsch, Anja Knueppel‐Ruppert, Verena Graeff, Andrea Kriegisch‐Stumpf, Harald Dormann, Julia C. Stingl, Katja S. Just   +8 more
wiley   +1 more source

Renin-Angiotensin-Aldosterone System Activation and Diuretic Response in Ambulatory Patients With Heart FailurePlain-Language Summary

Kidney Medicine, 2022
Rationale & Objective: Heart failure treatment relies on loop diuretics to induce natriuresis and decongestion, but the therapy is often limited by diuretic resistance.
Jonathan G. Amatruda, Rebecca Scherzer, Veena S. Rao, Juan B. Ivey-Miranda, Michael G. Shlipak, Michelle M. Estrella, Jeffrey M. Testani   +6 more
doaj   +1 more source

Diuretic Intensity Score and Mortality in Hospitalized Heart Failure Patients: A Multicenter Propensity‐Matched Analysis

Clinical Cardiology, Volume 49, Issue 6, June 2026.
In two independent cohorts of 17 826 hospitalized heart failure patients (MIMIC‐IV and a Chinese database), a higher Diuretic Intensity Score was associated with lower 28‐ and 90‐day all‐cause mortality. These findings are hypothesis‐generating and warrant validation in prospective randomized trials.
Jianwei Zhou
wiley   +1 more source

Torsemide versus furosemide in heart failure patients: insights from Duke University Hospital.

, 2015
Furosemide has historically been the primary loop diuretic in heart failure patients despite data suggesting potential advantages with torsemide. We used the Duke Echocardiography Lab Database to investigate patients admitted with heart failure to Duke ...
Anstrom, Kevin J, Mentz, Robert J, Eisenstein, Eric L, OʼConnor, Christopher M, Buggey, Jonathan, Fiuzat, Mona, Velazquez, Eric J, Ersbøll, Mads K, Schulte, Phillip J, DeVore, Adam D   +9 more
core   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Guideline-Directed Medical Therapy in the Management of Cardiovascular Disease: A Cross-sectional Questionnaire-based Study amongst Indian Healthcare Professionals [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Guideline-Directed Medical Therapies (GDMT) are evidence-based treatments recommended by clinical practice guidelines for the management of Cardiovascular Diseases (CVDs).
Prafulla Kerkar, Rajeev Garg, Abhishek Shukla, Viveka Kumar, Akshyaya Pradhan, Arindam Pande, Johan Christopher, Febin Francis, Nitin Zalte, Amarnath Sugumaran   +9 more
doaj   +1 more source

Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 267-273, May 2026.
ABSTRACT The pharmacokinetics of sildenafil are ill‐defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client‐owned dogs with
Mariko Yata, Teresa C. DeFrancesco, John D. Bonagura, Mark G. Papich   +3 more
wiley   +1 more source