Results 71 to 80 of about 9,787,526 (302)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Total antioxidant capacity in dogs with gastric dilatation and volvulus

Veterinární Medicína, 2012
The aim of this study was to determine total antioxidant capacity in dogs with gastric dilatation-volvulus syndrome (GDV) and its correlations with high mobility group box 1 protein (HMGB1) and lactate concentrations.
I. Uhrikova, K. Rehakova, L. Rauserova-Lexmaulova, A. Lojek, J. Doubek   +4 more
doaj   +1 more source

Comparative Evaluation of Total Antioxidant Capacities of Plant Polyphenols [PDF]

Molecules, 2016
Thirty-seven samples of naturally occurring phenolic compounds were evaluated using three common in vitro assays for total antioxidant activity (TAC) testing: the Trolox Equivalent Antioxidant Capacity (TEAC), the Ferric Reducing Antioxidant Potential (FRAP) and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, in addition to the Folin-
Kristóf Csepregi, Susanne Neugart, Monika Schreiner, Éva Hideg   +3 more
openaire   +5 more sources

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

TOTAL ANTIOXIDANT CAPACITY AND FRAILTY IN OLDER MEN

, 2023
TOTAL ANTIOXIDANT CAPACITY AND FRAILTY IN OLDER ...
Julie Pasco (13077054), Sophia Sui (13095996), Chiara Bortolasci (13060449), Kara Kew (13073589), Sharon Brennan-Olsen (13093467), Lana Williams (13082460), Monica Chimwemwe Tembo (13084134), Mark Kotowicz (13079622)   +7 more
core  

The plasma bioavailability of nitrate and betanin from Beta vulgaris rubra in humans [PDF]

, 2016
Purpose To evaluate the plasma bioavailability of betanin and nitric oxide (NOx) after consuming beetroot juice (BTJ) and whole beetroot (BF). BTJ and BF were also analysed for antioxidant capacity, polyphenol content (TPC) and betalain content ...
Constantinou, Costas, Stevenson, Emma, Emma J Stevenson (7516535), Howatson, Glyn, Tom Clifford (7468394), West, Daniel J., Clifford, Tom, Keane, Karen, Keane, Karen M., Daniel J West (7516571), Karen M Keane (7516589), Costas M. Constantinou, Karen M. Keane, Constantinou, Costas M., Daniel J. West, Glyn Howatson (324877), Costas M Constantinou (7516586), Glyn Howatson, Emma J. Stevenson, West, Dan, Tom Clifford   +20 more
core   +2 more sources

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Colostrum and milk characteristics in Murgese breed mares

Czech Journal of Animal Science, 2017
The physicochemical composition and antioxidant activity of Murgese mare's colostrum and milk during lactation were analyzed. Colostrum and milk samples from 14 lactating mares were collected on the 1st and 2nd day after foaling, and then at 15, 90, and ...
Carlo Cosentino, Giovanni Notarnicola, Rosanna Paolino, Carmine D'Adamo, Cristiana Labella, Mauro Musto, Pierangelo Freschi   +6 more
doaj   +1 more source

Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity [PDF]

Cancer Research, 2005
Abstract Paclitaxel, one of the most commonly prescribed chemotherapeutic agents, is active against a wide spectrum of human cancer. The mechanism of its cytotoxicity, however, remains controversial. Our results indicate that paclitaxel treatment increases levels of superoxide, hydrogen peroxide, nitric oxide (NO), oxidative DNA adducts,
Balakrishnan, Ramanathan, Kun-Yan, Jan, Chien-Hung, Chen, Tzyh-Chyuan, Hour, Hong-Jen, Yu, Yeong-Shiau, Pu   +5 more
openaire   +2 more sources