Results 81 to 90 of about 272,368 (356)

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Total phenols and flavonoids and antioxidant activity of Lampaya medicinalis F. Phil. leaf extracts [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2013
Context: Lampaya medicinalis F. Phil. (Verbenaceae) is a plant that grows in northern of Chile and it is used in ethnomedicine to treat bone pain, as an analgesic, in kidney ailments, disorders of the prostate, liver disease and dyspepsia, although there
Gabino Garrido, Macarena Ortiz, Patricia Pozo   +2 more
doaj  

Impact of different solvents on the recovery of bioactive compounds and antioxidant properties from lemon (Citrus limon L.) pomace waste [PDF]

, 2016
The effects of different solvents on the recovery of (i) extractable solids (ES), (ii) total phenolic compounds (TPC), (iii) total flavonoid content (TFC), (iv) vitamin C, and (v) antioxidant activity from lemon pomace waste were investigated.
Bowyer, Michael C., Golding, John B., Papoutsis, Konstantinos, Pristijono, Penta, Scarlett, Christopher J., Stathopoulos, Costas E., Vuong, Quan V.   +6 more
core   +2 more sources

Association mapping for total polyphenol content, total flavonoid content and antioxidant activity in barley [PDF]

BMC Genomics, 2018
The interest has been increasing on the phenolic compounds in plants because of their nutritive function as food and the roles regulating plant growth. However, their underlying genetic mechanism in barley is still not clear.A genome-wide association study (GWAS) was conducted for total phenolic content (TPC), total flavonoid content (FLC) and ...
Zhigang Han, Jingjie Zhang, Shengguan Cai, Xiaohui Chen, Xiaoyan Quan, Guoping Zhang   +5 more
openaire   +3 more sources

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Quantification of Phenolic Compounds and In Vitro Radical Scavenging Abilities with Leaf Extracts from Two Varieties of Psidium guajava L.

Antioxidants, 2018
Guava leaf (Psidium guajava L.) extracts are used in both traditional medicine and the pharmaceutical industry. The antioxidant compounds in P. guajava leaves can have positive effects including anti-inflammatory, anti-hyperglycemic, hepatoprotective ...
Julio César Camarena-Tello, Héctor Eduardo Martínez-Flores, Ma. Guadalupe Garnica-Romo, José Saúl Padilla-Ramírez, Alfredo Saavedra-Molina, Osvaldo Alvarez-Cortes, María Carmen Bartolomé-Camacho, José Octavio Rodiles-López   +7 more
doaj   +1 more source

Antiprotozoal activity of flavonoids from Eupatorium arnottianum [PDF]

, 2017
Dichloromethane and ethanol extracts of Eupatorium arnottianum were evaluated for invitroleishmanicidal activity. The dichloromethane extract produced 80% and 85% of growthinhibition on both Leishmania mexicana and Leishmania amazonensis promastigotes ...
Cazorla, Silvia Ines, Clavin, Maria Liliana, Frank, Fernanda María, Malchiodi, Emilio Luis, Martino, Virginia Susana, Muschietti, Liliana Victoria, Sosa, Miguel Angel, Spina Zapata, Renata María   +7 more
core  

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

Comparison of phenolic and flavonoid content and antioxidant activity in vitro among potato varieties. [PDF]

, 2011
Conference paperDiets rich in fruits and vegetables have been associated with a lower incidence of cancer and heart disease, which may be related to the antioxidant activity of bioactive compounds present in these foods.
Brunton, Nigel, Gaffney, Michael, O'Brien, Nora M., Reilly, Kim, Valcarel, Jesus   +4 more
core  

Optimizing a sustainable ultrasound assisted extraction method for the recovery of polyphenols from lemon by-products:comparison with hot water and organic solvent extractions [PDF]

, 2018
Response surface methodology (RSM) based on a three-factor and three-level Box–Behnken design was employed for optimizing the aqueous ultrasound-assisted extraction (AUAE) conditions, including extraction time (35–45 min), extraction temperature (45–55 ...
Bowyer, Michael C., Golding, John B., Papoutsis, Konstantinos, Pristijono, Penta, Scarlett, Christopher J., Stathopoulos, Costas E., Vuong, Quan V.   +6 more
core   +2 more sources